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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNOT6L

Summary for CNOT6L

Gene information	Gene symbol	CNOT6L
	Ensembl ID	ENSG00000138767
	Entrez ID	246175
	Gene name	CCR4-NOT transcription complex subunit 6 like
	Synonyms	Ccr4b\|DKFZp434K098
	Gene type	protein_coding
	UniProtAcc	Q96LI5

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Dataset with differentially expressed gene: CNOT6L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.286346	3.38e-28
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.300669	5.61e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.365386	1.19e-04
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.323972	2.56e-33
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.54036	7.98e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.397474	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.292592	1.90e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.31443	2.00e-05
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	CD4+ T cells	-0.270828	6.25e-03

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Expression of CNOT6L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNOT6L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNOT6L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNOT6L	hsa-miR-5011-5p	99.9954	NM_001286790
CNOT6L	hsa-miR-190a-3p	99.9786	NM_001286790
CNOT6L	hsa-miR-4666a-3p	99.963	NM_001286790
CNOT6L	hsa-miR-3148	99.9474	NM_001286790
CNOT6L	hsa-miR-3613-3p	99.3866	NM_001286790
CNOT6L	hsa-let-7b-3p	99.3306	NM_001286790
CNOT6L	hsa-let-7a-3p	99.3306	NM_001286790
CNOT6L	hsa-let-7f-1-3p	99.3306	NM_001286790
CNOT6L	hsa-miR-98-3p	99.3306	NM_001286790
CNOT6L	hsa-miR-302c-5p	99.1353	NM_001286790
CNOT6L	hsa-miR-5692a	99.099	NM_001286790
CNOT6L	hsa-miR-3662	98.718	NM_001286790
CNOT6L	hsa-miR-4282	98.6843	NM_001286790
CNOT6L	hsa-miR-3688-3p	98.5023	NM_001286790
CNOT6L	hsa-miR-5197-5p	98.3645	NM_001286790
CNOT6L	hsa-miR-12136	97.8663	NM_001286790
CNOT6L	hsa-miR-23b-3p	97.7995	NM_001286790
CNOT6L	hsa-miR-23c	97.7995	NM_001286790
CNOT6L	hsa-miR-23a-3p	97.7995	NM_001286790
CNOT6L	hsa-miR-520d-5p	97.7981	NM_001286790
CNOT6L	hsa-miR-524-5p	97.7981	NM_001286790
CNOT6L	hsa-miR-548ac	97.6143	NM_001286790
CNOT6L	hsa-miR-548z	97.6143	NM_001286790
CNOT6L	hsa-miR-548h-3p	97.6143	NM_001286790
CNOT6L	hsa-miR-300	97.5158	NM_001286790
CNOT6L	hsa-miR-381-3p	97.5158	NM_001286790
CNOT6L	hsa-miR-3920	97.269	NM_001286790
CNOT6L	hsa-miR-548bb-3p	97.2452	NM_001286790
CNOT6L	hsa-miR-548d-3p	97.2452	NM_001286790
CNOT6L	hsa-miR-138-5p	97.1491	NM_001286790
CNOT6L	hsa-miR-6768-5p	96.804	NM_001286790
CNOT6L	hsa-miR-371b-5p	96.6063	NM_001286790
CNOT6L	hsa-miR-616-5p	96.6063	NM_001286790
CNOT6L	hsa-miR-373-5p	96.6063	NM_001286790
CNOT6L	hsa-miR-3143	96.5925	NM_001286790
CNOT6L	hsa-miR-374c-5p	96.5631	NM_001286790
CNOT6L	hsa-miR-655-3p	96.5631	NM_001286790
CNOT6L	hsa-miR-646	96.4383	NM_001286790
CNOT6L	hsa-miR-4789-3p	96.3731	NM_001286790
CNOT6L	hsa-miR-9-5p	96.3013	NM_001286790
CNOT6L	hsa-miR-338-5p	96.2375	NM_001286790
CNOT6L	hsa-miR-16-5p	95.6165	NM_001286790
CNOT6L	hsa-miR-195-5p	95.6165	NM_001286790
CNOT6L	hsa-miR-15b-5p	95.6165	NM_001286790
CNOT6L	hsa-miR-15a-5p	95.6165	NM_001286790
CNOT6L	hsa-miR-4694-3p	95.5545	NM_001286790
CNOT6L	hsa-miR-513a-3p	95.4243	NM_001286790
CNOT6L	hsa-miR-513c-3p	95.4243	NM_001286790
CNOT6L	hsa-miR-424-5p	95.2452	NM_001286790
CNOT6L	hsa-miR-497-5p	95.2452	NM_001286790

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Motifs and transcription factors (TFs) regulating CNOT6L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNOT6L	tfdimers__MD00546	HOXC8; NFE2L1 (directAnnotation).
CNOT6L	transfac_pro__M06363	ZNF730 (directAnnotation).
CNOT6L	metacluster_9.47	PAX7 (inferredBy_Orthology).
CNOT6L	transfac_pro__M01783	SP2 (directAnnotation).
CNOT6L	transfac_pro__M02848	EGR1 (inferredBy_Orthology).
CNOT6L	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CNOT6L	transfac_pro__M07475	TBX5 (inferredBy_Orthology).
CNOT6L	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
CNOT6L	metacluster_84.2	RARA (directAnnotation).
CNOT6L	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CNOT6L	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CNOT6L	jaspar__MA1650.1	ZBTB14 (directAnnotation).
CNOT6L	transfac_pro__M02090	E2F4 (directAnnotation).
CNOT6L	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
CNOT6L	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CNOT6L	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
CNOT6L	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
CNOT6L	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
CNOT6L	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
CNOT6L	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CNOT6L	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
CNOT6L	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
CNOT6L	hdpi__HES5	HES5 (directAnnotation).
CNOT6L	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
CNOT6L	jaspar__MA1522.1	MAZ (directAnnotation).
CNOT6L	kznf__EGR2_Barrera2016.1_PBM	EGR2 (directAnnotation).
CNOT6L	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
CNOT6L	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
CNOT6L	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
CNOT6L	metacluster_198.2	AHR; AHR; ARNT; BHLHE40; MAX; MYC; ZNF780A (directAnnotation). MTF1 (inferredBy_Orthology).
CNOT6L	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
CNOT6L	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
CNOT6L	hdpi__NRL	NRL (directAnnotation).
CNOT6L	metacluster_37.4	FOXN2 (directAnnotation).
CNOT6L	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CNOT6L	transfac_public__M00446	SPZ1 (directAnnotation).
CNOT6L	dbtfbs__ZNF770_HEK293_ENCSR242BGR_merged_N1	ZNF770 (directAnnotation).
CNOT6L	hdpi__OTUD4	OTUD4 (directAnnotation).
CNOT6L	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
CNOT6L	kznf__ZBTB26_Schmitges2016_ChIP-seq	ZBTB26 (directAnnotation).
CNOT6L	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CNOT6L	swissregulon__hs__EPAS1	EPAS1 (directAnnotation).
CNOT6L	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CNOT6L	transfac_pro__M02898	SMAD3 (directAnnotation).
CNOT6L	transfac_pro__M04866	HDAC2 (directAnnotation).
CNOT6L	hocomoco__ZEP2_HUMAN.H11MO.0.D	HIVEP2 (directAnnotation).
CNOT6L	transfac_public__M00373	PAX4 (directAnnotation).
CNOT6L	hdpi__HTATIP2	HTATIP2 (directAnnotation).
CNOT6L	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CNOT6L	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."