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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: CNOT4

Summary for CNOT4

Gene informationGene symbol

CNOT4

Ensembl ID

ENSG00000080802

Entrez ID

4850

Gene nameCCR4-NOT transcription complex subunit 4
SynonymsCLONE243|NOT4|NOT4H
Gene typeprotein_coding
UniProtAcc

O95628


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Dataset with differentially expressed gene: CNOT4

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.2875730.00e+00

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Expression of CNOT4 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CNOT4

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNOT4

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CNOT4hsa-miR-6878-5p98.0202NM_001190850
CNOT4hsa-miR-4652-3p97.3823NM_001190850
CNOT4hsa-miR-519b-3p96.95NM_001008225
CNOT4hsa-miR-519a-3p96.95NM_001008225
CNOT4hsa-miR-519c-3p96.95NM_001008225
CNOT4hsa-miR-6770-5p96.4011NM_001190850
CNOT4hsa-miR-93-5p95.6777NM_001008225
CNOT4hsa-miR-17-5p95.6777NM_001008225
CNOT4hsa-miR-20b-5p95.6777NM_001008225
CNOT4hsa-miR-106b-5p95.6777NM_001008225
CNOT4hsa-miR-106a-5p95.6777NM_001008225
CNOT4hsa-miR-20a-5p95.6777NM_001008225
CNOT4hsa-miR-449995.0496NM_001008225
CNOT4hsa-miR-4795-3p94.1326NM_001008225
CNOT4hsa-miR-6768-3p94.0589NM_001008225
CNOT4hsa-miR-519d-3p93.8685NM_001008225
CNOT4hsa-miR-1910-3p93.339NM_001008225
CNOT4hsa-miR-6511a-5p93.339NM_001008225
CNOT4hsa-miR-526b-3p92.8664NM_001008225
CNOT4hsa-miR-6823-5p92.6525NM_001190850
CNOT4hsa-miR-4728-3p92.3654NM_001008225
CNOT4hsa-miR-548f-5p92.3316NM_001008225
CNOT4hsa-miR-548x-5p92.3316NM_001008225
CNOT4hsa-miR-548g-5p92.3316NM_001008225
CNOT4hsa-miR-548aj-5p92.3316NM_001008225
CNOT4hsa-miR-126-5p91.8548NM_001190850
CNOT4hsa-miR-125a-3p90.8036NM_001190850
CNOT4hsa-miR-430390.6773NM_001008225
CNOT4hsa-miR-361890.6413NM_001008225
CNOT4hsa-miR-668-3p90.5529NM_001190850
CNOT4hsa-miR-589-3p90.3927NM_001190850
CNOT4hsa-miR-17-3p90.2523NM_001190850
CNOT4hsa-miR-805790.0397NM_001008225
CNOT4hsa-miR-6760-5p89.8882NM_001190850
CNOT4hsa-miR-139-5p89.8778NM_001008225
CNOT4hsa-miR-23b-3p89.2908NM_001008225
CNOT4hsa-miR-23a-3p89.2908NM_001008225
CNOT4hsa-miR-23c89.2908NM_001008225
CNOT4hsa-miR-3124-3p89.007NM_001190850
CNOT4hsa-miR-301b-3p88.471NM_001008225
CNOT4hsa-miR-301a-3p88.471NM_001008225
CNOT4hsa-miR-366688.471NM_001008225
CNOT4hsa-miR-130a-3p88.471NM_001008225
CNOT4hsa-miR-429588.471NM_001008225
CNOT4hsa-miR-130b-3p88.471NM_001008225
CNOT4hsa-miR-454-3p88.471NM_001008225
CNOT4hsa-miR-4777-5p88.1647NM_001008225
CNOT4hsa-miR-4768-3p87.7627NM_001008225
CNOT4hsa-miR-4766-3p87.4609NM_001190850
CNOT4hsa-miR-129786.5686NM_001008225
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Motifs and transcription factors (TFs) regulating CNOT4

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CNOT4metacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CNOT4dbtfbs__E2F8_representative_N1E2F8 (directAnnotation).
CNOT4transfac_pro__M04950EGR1 (directAnnotation).
CNOT4metacluster_34.4ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
CNOT4taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_reprERF; HES7 (directAnnotation).
CNOT4transfac_pro__M00652NRF1 (directAnnotation).
CNOT4hdpi__ETV4ETV4 (directAnnotation).
CNOT4transfac_pro__M04866HDAC2 (directAnnotation).
CNOT4metacluster_34.1ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CNOT4swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
CNOT4metacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CNOT4metacluster_34.3EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."