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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNN2

Summary for CNN2

Gene information	Gene symbol	CNN2
	Ensembl ID	ENSG00000064666
	Entrez ID	1265
	Gene name	calponin 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q99439

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Dataset with differentially expressed gene: CNN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.278782	6.07e-40
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.442696	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.404237	1.55e-08
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.454256	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	0.435784	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.284179	1.20e-17
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.344002	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.418578	5.77e-20
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	0.268206	1.75e-19
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	-0.251144	5.22e-33
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.277471	3.06e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.255287	1.21e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.0141	1.22e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.309191	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.276889	3.18e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.406009	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.27157	8.27e-14
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.607623	1.00e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.370396	0.00e+00

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Expression of CNN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNN2	hsa-miR-625-5p	93.6425	NM_201277
CNN2	hsa-miR-133a-3p	93.5351	NM_001303499
CNN2	hsa-miR-133b	93.5351	NM_001303499
CNN2	hsa-miR-23a-3p	90.3784	NM_001303499
CNN2	hsa-miR-23b-3p	90.3784	NM_001303499
CNN2	hsa-miR-23c	90.3784	NM_001303499
CNN2	hsa-miR-548as-3p	87.3584	NM_201277
CNN2	hsa-miR-125b-1-3p	86.0933	NM_201277
CNN2	hsa-miR-497-3p	85.1582	NM_001303499

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Motifs and transcription factors (TFs) regulating CNN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNN2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CNN2	transfac_pro__M06035	ZNF749 (directAnnotation).
CNN2	transfac_pro__M01861	ATF1 (directAnnotation).
CNN2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
CNN2	metacluster_52.11	ZNF184 (directAnnotation).
CNN2	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
CNN2	metacluster_35.7	HINFP (inferredBy_Orthology).
CNN2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CNN2	transfac_pro__M05548	PLAGL2 (directAnnotation).
CNN2	metacluster_52.10	GTF3C2; ZNF436 (directAnnotation).
CNN2	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
CNN2	taipale_tf_pairs__TEAD4_HOXA13_RCATWCCNNNNNNTTTAYNNN_CAP_repr	HOXA13; TEAD4 (directAnnotation).
CNN2	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
CNN2	taipale_cyt_meth__PITX2_YTAATCCN_FL	PITX2 (directAnnotation).
CNN2	hdpi__ZBTB4	ZBTB4 (directAnnotation).
CNN2	metacluster_130.13	BRCA1 (directAnnotation).
CNN2	transfac_pro__M05941	ZNF471 (directAnnotation).
CNN2	swissregulon__hs__EBF1	EBF1 (directAnnotation).
CNN2	tfdimers__MD00041	CRX; HMBOX1 (directAnnotation).
CNN2	tfdimers__MD00210	CDX2; HMBOX1 (directAnnotation).
CNN2	hocomoco__DPRX_HUMAN.H11MO.0.D	DPRX (directAnnotation).
CNN2	tfdimers__MD00157	MYB; TLX2 (directAnnotation).
CNN2	transfac_pro__M08811	FOXL2 (directAnnotation).
CNN2	tfdimers__MD00549	CRX (directAnnotation).
CNN2	tfdimers__MD00416	HNF1A; HNF1B (directAnnotation).
CNN2	kznf__ZSCAN29_TF_Evolution_PBM	ZSCAN29 (directAnnotation).
CNN2	transfac_pro__M12358	MLX (inferredBy_Orthology).
CNN2	metacluster_85.7	ZSCAN29; ZSCAN29 (directAnnotation).
CNN2	tfdimers__MD00429	ARID3A; IKZF2 (directAnnotation).
CNN2	metacluster_9.26	LHX3 (directAnnotation).
CNN2	hdpi__PQBP1	PQBP1 (directAnnotation).
CNN2	taipale_tf_pairs__MYBL1_TBX21_AGGTGTGNCSGTTR_CAP_repr	MYBL1; TBX21 (directAnnotation).
CNN2	transfac_pro__M06806	PEG3 (directAnnotation).
CNN2	transfac_public__M00416	ALX1 (directAnnotation).
CNN2	metacluster_70.17	POU1F1 (directAnnotation).
CNN2	transfac_pro__M04950	EGR1 (directAnnotation).
CNN2	metacluster_0.7	DPRX; DPRX; DPRX; RHOXF1; RHOXF1 (directAnnotation).
CNN2	transfac_pro__M07420	HES1 (directAnnotation).
CNN2	tfdimers__MD00247	CRX; HOXA10 (directAnnotation).
CNN2	transfac_public__M00077	GATA3 (directAnnotation).
CNN2	transfac_pro__M01237	TERF1 (directAnnotation).
CNN2	transfac_pro__M05597	ZNF174 (directAnnotation).
CNN2	transfac_pro__M01228	MAF (directAnnotation).
CNN2	hocomoco__SOX9_HUMAN.H11MO.1.B	SOX9 (directAnnotation).
CNN2	tfdimers__MD00470	TP53 (directAnnotation).
CNN2	cisbp__M00273	CRX (directAnnotation).
CNN2	transfac_pro__M04810	USF2 (directAnnotation).
CNN2	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
CNN2	transfac_pro__M04870	HDAC2 (directAnnotation).
CNN2	hdpi__RAX	RAX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."