Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNIH4

Summary for CNIH4

Gene information	Gene symbol	CNIH4
	Ensembl ID	ENSG00000143771
	Entrez ID	29097
	Gene name	cornichon family AMPA receptor auxiliary protein 4
	Synonyms	HSPC163
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: CNIH4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.291596	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.322199	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.445332	8.57e-25
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.261848	1.56e-38
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.309958	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.735686	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.603663	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.588817	1.76e-41
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.726399	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.463651	3.94e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.889059	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.994921	0.00e+00

Top

Expression of CNIH4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CNIH4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CNIH4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNIH4	hsa-miR-5011-5p	98.4159	NM_001277198
CNIH4	hsa-miR-3120-3p	97.3778	NM_001277198
CNIH4	hsa-miR-545-3p	94.7221	NM_001277199
CNIH4	hsa-miR-1277-5p	92.3952	NM_001277198
CNIH4	hsa-miR-6842-5p	92.2922	NM_001277199
CNIH4	hsa-miR-7110-5p	92.2922	NM_001277199
CNIH4	hsa-miR-6752-5p	91.9274	NM_001277199
CNIH4	hsa-miR-548p	91.7593	NM_001277199
CNIH4	hsa-miR-4441	89.5231	NM_001277199
CNIH4	hsa-miR-518a-5p	89.2438	NM_001277199
CNIH4	hsa-miR-527	89.2438	NM_001277199
CNIH4	hsa-miR-4708-3p	89.1991	NM_001277200
CNIH4	hsa-miR-676-5p	88.4017	NM_001277198
CNIH4	hsa-miR-5006-5p	88.3245	NM_001277199
CNIH4	hsa-miR-4521	87.7579	NM_001277198
CNIH4	hsa-miR-4270	87.5715	NM_001277199
CNIH4	hsa-miR-149-5p	87.1657	NM_001277198
CNIH4	hsa-miR-208b-5p	86.4345	NM_001277199
CNIH4	hsa-miR-208a-5p	86.4345	NM_001277199
CNIH4	hsa-miR-6754-5p	86.1735	NM_001277199
CNIH4	hsa-miR-5689	85.7157	NM_001277200
CNIH4	hsa-miR-4659a-3p	84.2166	NM_001277199
CNIH4	hsa-miR-4659b-3p	84.2166	NM_001277199
CNIH4	hsa-miR-10b-5p	82.1465	NM_001277199
CNIH4	hsa-miR-10a-5p	82.1465	NM_001277199
CNIH4	hsa-miR-135b-5p	80.559	NM_001277199
CNIH4	hsa-miR-135a-5p	80.559	NM_001277199

Page: 1

Top

Motifs and transcription factors (TFs) regulating CNIH4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNIH4	taipale_tf_pairs__MYBL1_ELF1_NMCCGGAACCGTTR_CAP_repr	ELF1; MYBL1 (directAnnotation).
CNIH4	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
CNIH4	hdpi__ETV4	ETV4 (directAnnotation).
CNIH4	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CNIH4	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CNIH4	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CNIH4	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CNIH4	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
CNIH4	cisbp__M02645	ETS1 (directAnnotation).
CNIH4	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CNIH4	jaspar__MA1932.1	HOXB13 (directAnnotation).
CNIH4	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CNIH4	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CNIH4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CNIH4	cisbp__M07938	E2F1 (directAnnotation).
CNIH4	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CNIH4	metacluster_7.13	ZFX (directAnnotation).
CNIH4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CNIH4	cisbp__M00968	MTF2 (directAnnotation).
CNIH4	metacluster_163.2	ZNF682 (directAnnotation).
CNIH4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CNIH4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CNIH4	transfac_pro__M05423	RREB1 (directAnnotation).
CNIH4	transfac_pro__M06077	ZNF716 (directAnnotation).
CNIH4	tfdimers__MD00291	FOXO1; YY2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."