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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CMTR2

Summary for CMTR2

Gene information	Gene symbol	CMTR2
	Ensembl ID	ENSG00000180917
	Entrez ID	55783
	Gene name	cap methyltransferase 2
	Synonyms	AFT\|FLJ11171\|FTSJD1\|MTr2
	Gene type	protein_coding
	UniProtAcc	Q8IYT2

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Dataset with differentially expressed gene: CMTR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.258541	0.00e+00

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Expression of CMTR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CMTR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CMTR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CMTR2	hsa-miR-106b-5p	96.4988	NM_001099642
CMTR2	hsa-miR-20a-5p	96.4988	NM_001099642
CMTR2	hsa-miR-6792-5p	96.1965	NM_018348
CMTR2	hsa-miR-93-5p	95.5999	NM_001099642
CMTR2	hsa-miR-17-5p	95.5999	NM_001099642
CMTR2	hsa-miR-519d-3p	95.5999	NM_001099642
CMTR2	hsa-miR-20b-5p	95.5999	NM_001099642
CMTR2	hsa-miR-526b-3p	95.5999	NM_001099642
CMTR2	hsa-miR-106a-5p	95.5999	NM_001099642
CMTR2	hsa-miR-3180-5p	92.2829	NM_018348
CMTR2	hsa-miR-3529-3p	89.8929	NM_018348
CMTR2	hsa-miR-5189-5p	88.4832	NM_018348
CMTR2	hsa-miR-1285-3p	88.4832	NM_018348
CMTR2	hsa-miR-612	88.4832	NM_018348
CMTR2	hsa-miR-6860	88.4832	NM_018348
CMTR2	hsa-miR-3187-5p	88.4832	NM_018348
CMTR2	hsa-miR-345-3p	88.0487	NM_018348
CMTR2	hsa-miR-302e	86.4961	NM_001099642
CMTR2	hsa-miR-9-5p	85.6175	NM_018348
CMTR2	hsa-miR-520e-5p	85.5753	NM_018348
CMTR2	hsa-miR-4711-5p	84.997	NM_018348
CMTR2	hsa-miR-1193	84.7978	NM_018348
CMTR2	hsa-miR-302b-3p	83.9978	NM_001099642
CMTR2	hsa-miR-520a-3p	83.9978	NM_001099642
CMTR2	hsa-miR-302c-3p	83.9978	NM_001099642
CMTR2	hsa-miR-520e-3p	83.9978	NM_001099642
CMTR2	hsa-miR-373-3p	83.9978	NM_001099642
CMTR2	hsa-miR-302d-3p	83.9978	NM_001099642
CMTR2	hsa-miR-372-3p	83.9978	NM_001099642
CMTR2	hsa-miR-520c-3p	83.9978	NM_001099642
CMTR2	hsa-miR-302a-3p	83.9978	NM_001099642
CMTR2	hsa-miR-520d-3p	83.9978	NM_001099642
CMTR2	hsa-miR-520b-3p	83.9978	NM_001099642
CMTR2	hsa-miR-1912-5p	82.1972	NM_018348
CMTR2	hsa-miR-12123	82.1226	NM_001099642
CMTR2	hsa-miR-8063	80.851	NM_018348

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Motifs and transcription factors (TFs) regulating CMTR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CMTR2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CMTR2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CMTR2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CMTR2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CMTR2	metacluster_7.13	ZFX (directAnnotation).
CMTR2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CMTR2	transfac_pro__M01175	ZBTB7B (directAnnotation).
CMTR2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CMTR2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CMTR2	transfac_pro__M01303	SP1 (directAnnotation).
CMTR2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CMTR2	transfac_pro__M02090	E2F4 (directAnnotation).
CMTR2	transfac_pro__M01714	KLF15 (directAnnotation).
CMTR2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CMTR2	transfac_pro__M02089	E2F3 (directAnnotation).
CMTR2	metacluster_3.14	WT1; WT1 (directAnnotation).
CMTR2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CMTR2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CMTR2	transfac_pro__M02281	SP1 (directAnnotation).
CMTR2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CMTR2	transfac_pro__M02898	SMAD3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."