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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CMTM6

Summary for CMTM6

Gene information	Gene symbol	CMTM6
	Ensembl ID	ENSG00000091317
	Entrez ID	54918
	Gene name	CKLF like MARVEL transmembrane domain containing 6
	Synonyms	CKLFSF6\|FLJ20396
	Gene type	protein_coding
	UniProtAcc	Q9NX76

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Dataset with differentially expressed gene: CMTM6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.29422	9.63e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.261982	5.21e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.393655	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.304952	9.53e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.67653	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.590285	2.35e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.541003	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.269392	3.93e-18
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.509274	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.521261	2.67e-42
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.253154	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.291145	0.00e+00

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Expression of CMTM6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CMTM6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CMTM6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CMTM6	hsa-miR-3163	99.956	NM_017801
CMTM6	hsa-miR-3913-3p	97.0631	NM_017801
CMTM6	hsa-miR-4789-5p	96.4933	NM_017801
CMTM6	hsa-miR-4282	94.9973	NM_017801
CMTM6	hsa-miR-6730-3p	94.7653	NM_017801
CMTM6	hsa-miR-589-5p	93.9926	NM_017801
CMTM6	hsa-miR-568	93.0752	NM_017801
CMTM6	hsa-miR-29b-2-5p	91.5572	NM_017801
CMTM6	hsa-miR-548d-3p	90.7656	NM_017801
CMTM6	hsa-miR-133a-3p	90.5693	NM_017801
CMTM6	hsa-miR-133b	90.5693	NM_017801
CMTM6	hsa-miR-548bb-3p	90.0269	NM_017801
CMTM6	hsa-miR-548z	90.0269	NM_017801
CMTM6	hsa-miR-548h-3p	90.0269	NM_017801
CMTM6	hsa-miR-548ac	90.0269	NM_017801
CMTM6	hsa-miR-3922-3p	89.0986	NM_017801
CMTM6	hsa-miR-4999-3p	88.2112	NM_017801
CMTM6	hsa-miR-519d-5p	88.1258	NM_017801
CMTM6	hsa-miR-4307	88.0729	NM_017801
CMTM6	hsa-miR-4762-3p	86.5716	NM_017801
CMTM6	hsa-miR-9-5p	86.4931	NM_017801
CMTM6	hsa-miR-6809-3p	86.1593	NM_017801
CMTM6	hsa-miR-4775	85.8102	NM_017801
CMTM6	hsa-miR-3667-5p	85.7023	NM_017801
CMTM6	hsa-miR-3176	84.8452	NM_017801
CMTM6	hsa-miR-4694-3p	84.2381	NM_017801
CMTM6	hsa-miR-125b-2-3p	84.1686	NM_017801
CMTM6	hsa-miR-150-5p	83.8344	NM_017801
CMTM6	hsa-miR-888-3p	83.5534	NM_017801
CMTM6	hsa-miR-651-3p	83.5166	NM_017801
CMTM6	hsa-miR-4263	83.3181	NM_017801
CMTM6	hsa-miR-4422	83.0347	NM_017801
CMTM6	hsa-miR-10527-5p	82.0096	NM_017801
CMTM6	hsa-miR-7152-3p	81.787	NM_017801
CMTM6	hsa-miR-6774-5p	81.1012	NM_017801
CMTM6	hsa-miR-635	81.1012	NM_017801
CMTM6	hsa-miR-136-5p	80.8082	NM_017801

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Motifs and transcription factors (TFs) regulating CMTM6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CMTM6	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CMTM6	transfac_pro__M06534	ZNF563 (directAnnotation).
CMTM6	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
CMTM6	transfac_pro__M05923	SCRT1 (inferredBy_Orthology).
CMTM6	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CMTM6	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CMTM6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CMTM6	hdpi__ETV4	ETV4 (directAnnotation).
CMTM6	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CMTM6	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CMTM6	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CMTM6	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
CMTM6	jaspar__MA1483.2	ELF2 (directAnnotation).
CMTM6	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CMTM6	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CMTM6	jaspar__MA1708.1	ETV7 (directAnnotation).
CMTM6	swissregulon__hs__DMC1	DMC1 (directAnnotation).
CMTM6	taipale_tf_pairs__ERF_DLX3_RSCGGAANNNNYAATTA_CAP_repr	DLX3; ERF (directAnnotation).
CMTM6	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CMTM6	hocomoco__HSFY1_HUMAN.H11MO.0.D	HSFY1; HSFY2 (directAnnotation).
CMTM6	transfac_pro__M05860	ZNF548 (directAnnotation).
CMTM6	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
CMTM6	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CMTM6	transfac_pro__M05768	ZNF544 (directAnnotation).
CMTM6	dbtfbs__E4F1_K562_ENCSR731LHZ_merged_N1	E4F1 (directAnnotation).
CMTM6	cisbp__M00341	PAX6 (directAnnotation).
CMTM6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CMTM6	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
CMTM6	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CMTM6	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CMTM6	transfac_pro__M01973	PLAG1 (directAnnotation).
CMTM6	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
CMTM6	hdpi__TP73	TP73 (directAnnotation).
CMTM6	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
CMTM6	hdpi__FLI1	FLI1 (directAnnotation).
CMTM6	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
CMTM6	transfac_pro__M06173	ZNF85 (directAnnotation).
CMTM6	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CMTM6	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CMTM6	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CMTM6	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
CMTM6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CMTM6	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CMTM6	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
CMTM6	cisbp__M02645	ETS1 (directAnnotation).
CMTM6	transfac_public__M00114	CREB1 (directAnnotation).
CMTM6	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CMTM6	metacluster_175.5	IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."