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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CMKLR1

Summary for CMKLR1

Gene information	Gene symbol	CMKLR1
	Ensembl ID	ENSG00000174600
	Entrez ID	1240
	Gene name	chemerin chemokine-like receptor 1
	Synonyms	RVER1
	Gene type	protein_coding
	UniProtAcc	Q99788

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Dataset with differentially expressed gene: CMKLR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.349336	3.83e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.330862	2.12e-05

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Expression of CMKLR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CMKLR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CMKLR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CMKLR1	hsa-miR-7977	94.273	NM_004072
CMKLR1	hsa-miR-330-5p	93.1406	NM_004072
CMKLR1	hsa-miR-326	92.1134	NM_004072
CMKLR1	hsa-miR-1285-3p	91.3212	NM_004072
CMKLR1	hsa-miR-5189-5p	91.3212	NM_004072
CMKLR1	hsa-miR-93-5p	90.2708	NM_004072
CMKLR1	hsa-miR-106a-5p	90.2708	NM_004072
CMKLR1	hsa-miR-20b-5p	90.2708	NM_004072
CMKLR1	hsa-miR-526b-3p	90.2708	NM_004072
CMKLR1	hsa-miR-519d-3p	90.2708	NM_004072
CMKLR1	hsa-miR-17-5p	90.2708	NM_004072
CMKLR1	hsa-miR-3191-5p	89.8903	NM_004072
CMKLR1	hsa-miR-6860	88.816	NM_004072
CMKLR1	hsa-miR-3187-5p	88.816	NM_004072
CMKLR1	hsa-miR-612	88.7667	NM_004072
CMKLR1	hsa-miR-9985	88.1149	NM_004072
CMKLR1	hsa-miR-27b-3p	88.1149	NM_004072
CMKLR1	hsa-miR-27a-3p	88.1149	NM_004072
CMKLR1	hsa-miR-20a-5p	87.9033	NM_004072
CMKLR1	hsa-miR-106b-5p	87.9033	NM_004072
CMKLR1	hsa-miR-6791-5p	85.2709	NM_004072
CMKLR1	hsa-miR-4292	85.2709	NM_004072
CMKLR1	hsa-miR-4656	84.7525	NM_004072
CMKLR1	hsa-miR-9500	84.6328	NM_004072
CMKLR1	hsa-miR-6768-3p	82.8958	NM_004072
CMKLR1	hsa-miR-1587	82.155	NM_004072
CMKLR1	hsa-miR-3620-5p	82.155	NM_004072

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Motifs and transcription factors (TFs) regulating CMKLR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CMKLR1	hocomoco__HSF1_HUMAN.H11MO.1.A	HSF1 (directAnnotation).
CMKLR1	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
CMKLR1	cisbp__M01815	CEBPE (inferredBy_Orthology).
CMKLR1	metacluster_172.22	E4F1 (inferredBy_Orthology).
CMKLR1	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).
CMKLR1	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).
CMKLR1	kznf__ZNF675_Najafabadi2015_ChIP-seq	ZNF675 (directAnnotation).
CMKLR1	transfac_pro__M06007	ZNF69 (directAnnotation).
CMKLR1	kznf__ZNF785_Imbeault2017_OM_MEME	ZNF785 (directAnnotation).
CMKLR1	cisbp__M02096	ANHX (directAnnotation).
CMKLR1	transfac_pro__M05453	ZBTB26 (directAnnotation).
CMKLR1	swissregulon__hs__ZNF784	ZNF784 (directAnnotation).
CMKLR1	transfac_pro__M06712	ZNF287 (directAnnotation).
CMKLR1	transfac_pro__M06252	ZNF415 (directAnnotation).
CMKLR1	transfac_pro__M06013	ZFP69B (directAnnotation).
CMKLR1	metacluster_134.6	FOXF1; FOXG1; ZNF74 (directAnnotation). FOXG1 (inferredBy_Orthology).
CMKLR1	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."