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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CLTC

Summary for CLTC

Gene information	Gene symbol	CLTC
	Ensembl ID	ENSG00000141367
	Entrez ID	1213
	Gene name	clathrin heavy chain
	Synonyms	CLTCL2\|Hc
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CLTC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.01638	3.25e-13
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.608204	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.434408	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.394757	3.91e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.277179	1.20e-25
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.267289	7.11e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.361092	4.09e-17
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.337706	5.03e-11
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.328476	7.81e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.326427	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.324135	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.548629	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.489166	0.00e+00

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Expression of CLTC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CLTC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CLTC	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CLTC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CLTC	hsa-miR-5003-5p	97.0556	NM_001288653
CLTC	hsa-miR-12135	95.7085	NM_004859
CLTC	hsa-miR-7154-5p	95.5985	NM_001288653
CLTC	hsa-miR-3679-3p	94.0418	NM_004859
CLTC	hsa-miR-3152-5p	93.3301	NM_001288653
CLTC	hsa-miR-1912-3p	93.2682	NM_004859
CLTC	hsa-miR-586	92.6577	NM_001288653
CLTC	hsa-miR-16-2-3p	92.5151	NM_004859
CLTC	hsa-miR-195-3p	92.5151	NM_004859
CLTC	hsa-miR-1295b-5p	92.4982	NM_004859
CLTC	hsa-miR-5700	91.7415	NM_001288653
CLTC	hsa-miR-206	91.6551	NM_001288653
CLTC	hsa-miR-1-3p	91.6551	NM_001288653
CLTC	hsa-miR-205-5p	91.6154	NM_001288653
CLTC	hsa-miR-8066	91.4698	NM_001288653
CLTC	hsa-miR-3120-3p	90.5565	NM_001288653
CLTC	hsa-miR-302c-5p	89.9711	NM_004859
CLTC	hsa-miR-4657	89.9336	NM_001288653
CLTC	hsa-miR-4491	89.9336	NM_001288653
CLTC	hsa-miR-431-5p	89.7873	NM_001288653
CLTC	hsa-miR-130a-3p	89.5582	NM_001288653
CLTC	hsa-miR-4295	89.5582	NM_001288653
CLTC	hsa-miR-301b-3p	89.5582	NM_001288653
CLTC	hsa-miR-130b-3p	89.5582	NM_001288653
CLTC	hsa-miR-301a-3p	89.5582	NM_001288653
CLTC	hsa-miR-3666	89.5582	NM_001288653
CLTC	hsa-miR-454-3p	89.4158	NM_001288653
CLTC	hsa-miR-613	89.4032	NM_001288653
CLTC	hsa-miR-193a-3p	88.3314	NM_004859
CLTC	hsa-miR-193b-3p	88.3314	NM_004859
CLTC	hsa-miR-576-5p	87.8378	NM_004859
CLTC	hsa-miR-6844	87.8314	NM_004859
CLTC	hsa-miR-208a-5p	87.6073	NM_001288653
CLTC	hsa-miR-208b-5p	87.6073	NM_001288653
CLTC	hsa-miR-6754-3p	87.5647	NM_001288653
CLTC	hsa-miR-5580-3p	87.4949	NM_004859
CLTC	hsa-miR-19a-3p	87.4259	NM_001288653
CLTC	hsa-miR-19b-3p	87.4259	NM_001288653
CLTC	hsa-miR-4645-3p	86.0909	NM_001288653
CLTC	hsa-miR-1250-3p	85.1483	NM_001288653
CLTC	hsa-miR-4251	85.0044	NM_001288653
CLTC	hsa-miR-3190-5p	84.6196	NM_004859
CLTC	hsa-miR-412-3p	84.6035	NM_001288653
CLTC	hsa-miR-433-3p	84.274	NM_001288653
CLTC	hsa-miR-4774-3p	83.7996	NM_001288653
CLTC	hsa-miR-6837-3p	83.3634	NM_001288653
CLTC	hsa-miR-5696	83.2639	NM_001288653
CLTC	hsa-miR-8060	83.1431	NM_001288653
CLTC	hsa-miR-4742-5p	82.1407	NM_004859
CLTC	hsa-miR-4433a-5p	81.9269	NM_001288653

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Motifs and transcription factors (TFs) regulating CLTC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CLTC	metacluster_7.13	ZFX (directAnnotation).
CLTC	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CLTC	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CLTC	hdpi__ETV4	ETV4 (directAnnotation).
CLTC	jaspar__MA0079.5	SP1 (directAnnotation).
CLTC	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CLTC	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
CLTC	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CLTC	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CLTC	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CLTC	hdpi__TP73	TP73 (directAnnotation).
CLTC	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CLTC	transfac_pro__M04826	EP300 (directAnnotation).
CLTC	transfac_pro__M04950	EGR1 (directAnnotation).
CLTC	transfac_pro__M04944	GABPA (directAnnotation).
CLTC	transfac_pro__M01182	HINFP (directAnnotation).
CLTC	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CLTC	hdpi__FLI1	FLI1 (directAnnotation).
CLTC	jaspar__MA1708.1	ETV7 (directAnnotation).
CLTC	cisbp__M02645	ETS1 (directAnnotation).
CLTC	transfac_pro__M05817	ZNF546 (directAnnotation).
CLTC	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
CLTC	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
CLTC	transfac_pro__M00492	STAT1 (directAnnotation).
CLTC	transfac_pro__M01298	MECP2 (directAnnotation).
CLTC	metacluster_141.4	GLIS2 (directAnnotation).
CLTC	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CLTC	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
CLTC	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
CLTC	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CLTC	hocomoco__HSFY1_HUMAN.H11MO.0.D	HSFY1; HSFY2 (directAnnotation).
CLTC	transfac_pro__M05956	BCL11B (directAnnotation).
CLTC	transfac_pro__M07436	WT1 (directAnnotation).
CLTC	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CLTC	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CLTC	transfac_pro__M02089	E2F3 (directAnnotation).
CLTC	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CLTC	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CLTC	transfac_pro__M08819	KLF2 (directAnnotation).
CLTC	transfac_pro__M01175	ZBTB7B (directAnnotation).
CLTC	cisbp__M00249	WT1 (directAnnotation).
CLTC	transfac_pro__M01118	WT1 (directAnnotation).
CLTC	swissregulon__hs__KLF6	KLF6 (directAnnotation).
CLTC	transfac_pro__M01303	SP1 (directAnnotation).
CLTC	transfac_pro__M00716	ZBTB14 (directAnnotation).
CLTC	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CLTC	transfac_pro__M07397	ZNF148 (directAnnotation).
CLTC	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
CLTC	transfac_pro__M01104	OVOL2 (directAnnotation).
CLTC	transfac_pro__M00986	CHURC1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."