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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CLSPN

Summary for CLSPN

Gene information	Gene symbol	CLSPN
	Ensembl ID	ENSG00000092853
	Entrez ID	63967
	Gene name	claspin
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9HAW4

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Dataset with differentially expressed gene: CLSPN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.29348	2.22e-12
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.323706	6.51e-13
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.454185	4.90e-25
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.388246	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.577199	7.97e-37
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.22054	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.287844	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.383815	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.488453	7.45e-26
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.550141	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.325987	0.00e+00

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Expression of CLSPN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CLSPN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CLSPN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CLSPN	hsa-miR-616-5p	98.4626	NM_001190481
CLSPN	hsa-miR-373-5p	98.4626	NM_001190481
CLSPN	hsa-miR-371b-5p	98.4626	NM_001190481
CLSPN	hsa-miR-12128	94.9706	NM_001190481
CLSPN	hsa-miR-33b-5p	93.1956	NM_001190481
CLSPN	hsa-miR-33a-5p	93.1956	NM_001190481
CLSPN	hsa-miR-150-5p	89.6118	NM_001190481
CLSPN	hsa-miR-3158-5p	88.247	NM_001190481
CLSPN	hsa-miR-3613-3p	87.1436	NM_001190481
CLSPN	hsa-miR-1285-3p	86.3931	NM_001190481
CLSPN	hsa-miR-6842-3p	86.2915	NM_001190481
CLSPN	hsa-miR-6780a-5p	86.0247	NM_001190481
CLSPN	hsa-miR-2116-3p	85.9561	NM_001190481
CLSPN	hsa-miR-6772-5p	84.8642	NM_001190481
CLSPN	hsa-miR-3187-5p	84.8157	NM_001190481
CLSPN	hsa-miR-7106-5p	84.2945	NM_001190481
CLSPN	hsa-miR-4784	82.9405	NM_001190481
CLSPN	hsa-miR-3150b-3p	82.9405	NM_001190481
CLSPN	hsa-miR-9902	82.267	NM_001190481
CLSPN	hsa-miR-4728-5p	82.144	NM_001190481
CLSPN	hsa-miR-509-3-5p	81.9699	NM_001190481
CLSPN	hsa-miR-509-5p	81.9699	NM_001190481
CLSPN	hsa-miR-6515-3p	81.9609	NM_001190481
CLSPN	hsa-miR-143-3p	81.7078	NM_001190481
CLSPN	hsa-miR-4770	81.7078	NM_001190481
CLSPN	hsa-miR-4705	81.559	NM_001190481
CLSPN	hsa-miR-7974	81.4571	NM_001190481
CLSPN	hsa-miR-532-3p	81.3327	NM_001190481

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Motifs and transcription factors (TFs) regulating CLSPN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CLSPN	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CLSPN	jaspar__MA0079.5	SP1 (directAnnotation).
CLSPN	transfac_pro__M04826	EP300 (directAnnotation).
CLSPN	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CLSPN	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CLSPN	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CLSPN	jaspar__MA1122.1	TFDP1 (directAnnotation).
CLSPN	hdpi__TP73	TP73 (directAnnotation).
CLSPN	transfac_public__M00024	E2F1 (directAnnotation).
CLSPN	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CLSPN	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CLSPN	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CLSPN	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CLSPN	metacluster_165.3	HOMEZ; HOMEZ; HOMEZ (directAnnotation).
CLSPN	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
CLSPN	jaspar__MA1932.1	HOXB13 (directAnnotation).
CLSPN	transfac_pro__M01182	HINFP (directAnnotation).
CLSPN	metacluster_172.6	CHD2; E2F1 (directAnnotation).
CLSPN	hocomoco__E2F8_HUMAN.H11MO.0.D	E2F8 (directAnnotation).
CLSPN	homer__TACGTGCV_HIF-1a	HIF1A (directAnnotation).
CLSPN	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
CLSPN	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."