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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CLMN

Summary for CLMN

Gene information	Gene symbol	CLMN
	Ensembl ID	ENSG00000165959
	Entrez ID	79789
	Gene name	calmin
	Synonyms	FLJ12383\|KIAA0500\|KIAA1188
	Gene type	protein_coding
	UniProtAcc	Q96JQ2

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Dataset with differentially expressed gene: CLMN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.46031	4.76e-14
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.287928	2.28e-08

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Expression of CLMN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CLMN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CLMN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CLMN	hsa-miR-95-5p	98.3804	NM_024734
CLMN	hsa-miR-5699-3p	96.0087	NM_024734
CLMN	hsa-miR-9902	95.8573	NM_024734
CLMN	hsa-miR-4421	94.6519	NM_024734
CLMN	hsa-miR-508-5p	93.8138	NM_024734
CLMN	hsa-miR-452-3p	93.5138	NM_024734
CLMN	hsa-miR-670-3p	92.2508	NM_024734
CLMN	hsa-miR-6854-5p	91.63	NM_024734
CLMN	hsa-miR-4643	91.5947	NM_024734
CLMN	hsa-miR-548n	91.5853	NM_024734
CLMN	hsa-miR-2467-3p	90.034	NM_024734
CLMN	hsa-miR-132-3p	88.4783	NM_024734
CLMN	hsa-miR-212-3p	88.4783	NM_024734
CLMN	hsa-miR-7977	88.3388	NM_024734
CLMN	hsa-miR-5695	88.2719	NM_024734
CLMN	hsa-miR-3658	87.4264	NM_024734
CLMN	hsa-miR-6083	86.0799	NM_024734
CLMN	hsa-miR-198	84.8802	NM_024734
CLMN	hsa-miR-5009-3p	84.737	NM_024734
CLMN	hsa-miR-767-3p	84.2425	NM_024734
CLMN	hsa-miR-4443	83.905	NM_024734
CLMN	hsa-miR-3662	83.4241	NM_024734
CLMN	hsa-miR-1236-5p	83.0328	NM_024734
CLMN	hsa-miR-6797-3p	82.9138	NM_024734
CLMN	hsa-miR-1276	82.8274	NM_024734
CLMN	hsa-miR-5196-5p	82.6582	NM_024734
CLMN	hsa-miR-4747-5p	82.6582	NM_024734
CLMN	hsa-miR-4297	82.6062	NM_024734
CLMN	hsa-miR-765	81.7377	NM_024734
CLMN	hsa-miR-577	81.2734	NM_024734
CLMN	hsa-miR-6076	81.2094	NM_024734
CLMN	hsa-miR-766-5p	80.7084	NM_024734
CLMN	hsa-miR-6806-3p	80.698	NM_024734
CLMN	hsa-miR-4533	80.2315	NM_024734
CLMN	hsa-miR-4306	80.0967	NM_024734

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Motifs and transcription factors (TFs) regulating CLMN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CLMN	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CLMN	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CLMN	transfac_pro__M04617	ZBTB7A (directAnnotation).
CLMN	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CLMN	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CLMN	transfac_pro__M07387	ZBTB7A (directAnnotation).
CLMN	transfac_pro__M07436	WT1 (directAnnotation).
CLMN	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CLMN	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CLMN	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CLMN	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CLMN	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CLMN	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CLMN	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CLMN	cisbp__M08198	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."