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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CLGN

Summary for CLGN

Gene information	Gene symbol	CLGN
	Ensembl ID	ENSG00000153132
	Entrez ID	1047
	Gene name	calmegin
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O14967

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Dataset with differentially expressed gene: CLGN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.881737	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.398764	0.00e+00

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Expression of CLGN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CLGN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CLGN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CLGN	hsa-miR-4766-5p	95.6397	NM_001130675
CLGN	hsa-miR-10395-3p	92.3414	NM_004362
CLGN	hsa-miR-4799-5p	90.959	NM_001130675
CLGN	hsa-miR-6780a-3p	90.4468	NM_004362
CLGN	hsa-miR-548x-3p	90.0782	NM_001130675
CLGN	hsa-miR-548aj-3p	90.0782	NM_001130675
CLGN	hsa-miR-153-5p	88.8709	NM_004362
CLGN	hsa-miR-654-3p	88.587	NM_004362
CLGN	hsa-miR-675-3p	88.3887	NM_004362
CLGN	hsa-miR-514b-3p	88.1824	NM_001130675
CLGN	hsa-miR-514a-3p	88.1824	NM_001130675
CLGN	hsa-miR-548aq-3p	87.2526	NM_001130675
CLGN	hsa-miR-548ah-3p	87.2526	NM_001130675
CLGN	hsa-miR-548am-3p	87.2526	NM_001130675
CLGN	hsa-miR-548ae-3p	87.2526	NM_001130675
CLGN	hsa-miR-548j-3p	87.2526	NM_001130675
CLGN	hsa-miR-548as-3p	87.1029	NM_004362
CLGN	hsa-miR-222-3p	85.2514	NM_004362
CLGN	hsa-miR-221-3p	85.2514	NM_004362
CLGN	hsa-miR-3908	84.8834	NM_004362
CLGN	hsa-miR-3059-5p	83.1803	NM_004362
CLGN	hsa-miR-4759	81.825	NM_004362
CLGN	hsa-miR-4495	81.3286	NM_001130675

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Motifs and transcription factors (TFs) regulating CLGN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CLGN	transfac_pro__M06035	ZNF749 (directAnnotation).
CLGN	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
CLGN	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
CLGN	transfac_pro__M02089	E2F3 (directAnnotation).
CLGN	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CLGN	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CLGN	transfac_pro__M04817	ZBTB33 (directAnnotation).
CLGN	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
CLGN	tfdimers__MD00483	ZBTB14 (directAnnotation).
CLGN	cisbp__M07938	E2F1 (directAnnotation).
CLGN	cisbp__M00968	MTF2 (directAnnotation).
CLGN	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CLGN	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CLGN	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CLGN	jaspar__MA1122.1	TFDP1 (directAnnotation).
CLGN	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."