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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CLDN12

Summary for CLDN12

Gene information	Gene symbol	CLDN12
	Ensembl ID	ENSG00000157224
	Entrez ID	9069
	Gene name	claudin 12
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CLDN12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.5645	2.38e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.31554	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.410633	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.539483	0.00e+00

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Expression of CLDN12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CLDN12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CLDN12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CLDN12	hsa-miR-3975	99.62	NM_001185072
CLDN12	hsa-miR-4777-3p	98.3787	NM_001185072
CLDN12	hsa-miR-651-3p	96.9903	NM_001185072
CLDN12	hsa-miR-4500	96.0132	NM_001185072
CLDN12	hsa-let-7a-5p	94.9868	NM_001185072
CLDN12	hsa-let-7b-5p	94.9868	NM_001185072
CLDN12	hsa-let-7e-5p	94.9868	NM_001185072
CLDN12	hsa-let-7g-5p	94.9868	NM_001185072
CLDN12	hsa-miR-98-5p	94.9868	NM_001185072
CLDN12	hsa-let-7f-5p	94.9868	NM_001185072
CLDN12	hsa-let-7c-5p	94.9868	NM_001185072
CLDN12	hsa-let-7i-5p	94.9868	NM_001185072
CLDN12	hsa-miR-142-3p	94.8195	NM_001185072
CLDN12	hsa-miR-2467-5p	94.2012	NM_001185072
CLDN12	hsa-miR-4458	93.5421	NM_001185072
CLDN12	hsa-let-7d-5p	93.5421	NM_001185072
CLDN12	hsa-miR-3188	93.462	NM_001185072
CLDN12	hsa-miR-6884-5p	93.462	NM_001185072
CLDN12	hsa-miR-485-5p	93.462	NM_001185072
CLDN12	hsa-miR-548c-3p	92.2195	NM_001185072
CLDN12	hsa-miR-8060	92.2045	NM_001185072
CLDN12	hsa-miR-4316	92.0931	NM_001185072
CLDN12	hsa-miR-3667-5p	91.83	NM_001185072
CLDN12	hsa-miR-196a-1-3p	90.7409	NM_001185072
CLDN12	hsa-miR-23c	90.6681	NM_001185072
CLDN12	hsa-miR-23b-3p	90.6681	NM_001185072
CLDN12	hsa-miR-23a-3p	90.6681	NM_001185072
CLDN12	hsa-miR-98-3p	90.6149	NM_001185072
CLDN12	hsa-let-7a-3p	90.6149	NM_001185072
CLDN12	hsa-let-7b-3p	90.6149	NM_001185072
CLDN12	hsa-let-7f-1-3p	90.6149	NM_001185072
CLDN12	hsa-miR-302b-5p	90.4278	NM_001185072
CLDN12	hsa-miR-302d-5p	90.4278	NM_001185072
CLDN12	hsa-miR-3120-3p	89.8365	NM_001185072
CLDN12	hsa-miR-616-5p	88.8324	NM_001185072
CLDN12	hsa-miR-33a-3p	88.5597	NM_001185072
CLDN12	hsa-miR-548m	88.3872	NM_001185072
CLDN12	hsa-miR-4678	88.2598	NM_001185072
CLDN12	hsa-miR-5692a	87.9005	NM_001185072
CLDN12	hsa-miR-548ad-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548am-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548w	87.3373	NM_001185072
CLDN12	hsa-miR-548d-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548ak	87.3373	NM_001185072
CLDN12	hsa-miR-548as-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548o-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548h-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548ae-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548au-5p	87.3373	NM_001185072
CLDN12	hsa-miR-548c-5p	87.3373	NM_001185072

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Motifs and transcription factors (TFs) regulating CLDN12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CLDN12	transfac_pro__M06035	ZNF749 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."