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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CLDN1

Summary for CLDN1

Gene information	Gene symbol	CLDN1
	Ensembl ID	ENSG00000163347
	Entrez ID	9076
	Gene name	claudin 1
	Synonyms	ILVASC\|SEMP1
	Gene type	protein_coding
	UniProtAcc	O95832

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Dataset with differentially expressed gene: CLDN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.322036	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.38543	2.54e-43

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Expression of CLDN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CLDN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CLDN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CLDN1	hsa-miR-190a-3p	98.5119	NM_021101
CLDN1	hsa-miR-4463	97.9895	NM_021101
CLDN1	hsa-miR-8068	97.8396	NM_021101
CLDN1	hsa-miR-10522-5p	97.0817	NM_021101
CLDN1	hsa-miR-3163	96.7156	NM_021101
CLDN1	hsa-miR-4282	96.6497	NM_021101
CLDN1	hsa-miR-4451	96.5256	NM_021101
CLDN1	hsa-miR-5011-5p	95.9224	NM_021101
CLDN1	hsa-miR-5682	95.5038	NM_021101
CLDN1	hsa-miR-29c-3p	95.1786	NM_021101
CLDN1	hsa-miR-29a-3p	95.1786	NM_021101
CLDN1	hsa-miR-29b-3p	95.1786	NM_021101
CLDN1	hsa-miR-3915	95.104	NM_021101
CLDN1	hsa-miR-4276	94.9498	NM_021101
CLDN1	hsa-miR-8060	93.7266	NM_021101
CLDN1	hsa-miR-4667-3p	93.6761	NM_021101
CLDN1	hsa-miR-3912-5p	91.8429	NM_021101
CLDN1	hsa-miR-5580-3p	90.4922	NM_021101
CLDN1	hsa-miR-4278	88.9664	NM_021101
CLDN1	hsa-miR-4650-3p	87.5625	NM_021101
CLDN1	hsa-miR-98-3p	87.5093	NM_021101
CLDN1	hsa-let-7a-3p	87.5093	NM_021101
CLDN1	hsa-let-7b-3p	87.5093	NM_021101
CLDN1	hsa-let-7f-1-3p	87.2518	NM_021101
CLDN1	hsa-miR-569	86.0483	NM_021101
CLDN1	hsa-miR-6508-3p	85.8583	NM_021101
CLDN1	hsa-miR-577	85.6866	NM_021101
CLDN1	hsa-miR-6871-3p	85.019	NM_021101
CLDN1	hsa-miR-95-5p	84.3348	NM_021101
CLDN1	hsa-miR-4536-5p	83.3053	NM_021101
CLDN1	hsa-miR-3185	82.6491	NM_021101
CLDN1	hsa-miR-3124-3p	82.4612	NM_021101
CLDN1	hsa-miR-6836-3p	81.439	NM_021101
CLDN1	hsa-miR-3152-3p	81.1699	NM_021101
CLDN1	hsa-miR-449b-3p	80.5928	NM_021101

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Motifs and transcription factors (TFs) regulating CLDN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CLDN1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
CLDN1	metacluster_52.11	ZNF184 (directAnnotation).
CLDN1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
CLDN1	metacluster_135.11	NR2C2 (directAnnotation).
CLDN1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CLDN1	cisbp__M00968	MTF2 (directAnnotation).
CLDN1	cisbp__M00341	PAX6 (directAnnotation).
CLDN1	metacluster_198.3	ZFP64 (directAnnotation).
CLDN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CLDN1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CLDN1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CLDN1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CLDN1	metacluster_175.1	ZNF283 (directAnnotation).
CLDN1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CLDN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CLDN1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CLDN1	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."