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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: CLASP1

Summary for CLASP1

Gene informationGene symbol

CLASP1

Ensembl ID

ENSG00000074054

Entrez ID

23332

Gene namecytoplasmic linker associated protein 1
SynonymsKIAA0622|MAST1
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: CLASP1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.2519061.46e-14

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Expression of CLASP1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CLASP1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CLASP1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CLASP1hsa-miR-848599.9554NM_001207051
CLASP1hsa-miR-508-3p98.6642NM_001142273
CLASP1hsa-miR-5010-3p95.2511NM_001207051
CLASP1hsa-miR-426295.01NM_001142273
CLASP1hsa-miR-42994.2304NM_001142273
CLASP1hsa-miR-200b-3p93.8937NM_001142273
CLASP1hsa-miR-200c-3p93.8937NM_001142273
CLASP1hsa-miR-548as-3p93.3752NM_001207051
CLASP1hsa-miR-181c-5p93.0042NM_001142273
CLASP1hsa-miR-181a-5p93.0042NM_001142273
CLASP1hsa-miR-181b-5p93.0042NM_001142273
CLASP1hsa-miR-181d-5p93.0042NM_001142273
CLASP1hsa-miR-319792.8125NM_001207051
CLASP1hsa-miR-219a-5p92.4984NM_001142273
CLASP1hsa-miR-4782-3p92.4984NM_001142273
CLASP1hsa-miR-6766-3p92.4984NM_001142273
CLASP1hsa-miR-6822-3p91.8643NM_001142273
CLASP1hsa-miR-3613-3p91.3336NM_001207051
CLASP1hsa-miR-4445-5p90.8486NM_001142273
CLASP1hsa-miR-805790.8352NM_001142273
CLASP1hsa-miR-76189.7936NM_001142273
CLASP1hsa-miR-1207-5p89.3419NM_001207051
CLASP1hsa-miR-4477a89.3365NM_001142273
CLASP1hsa-miR-6739-5p89.2955NM_001142273
CLASP1hsa-miR-4763-3p89.27NM_001207051
CLASP1hsa-miR-6825-5p89.2056NM_001142273
CLASP1hsa-miR-76088.1537NM_001142273
CLASP1hsa-miR-548p88.0971NM_001142273
CLASP1hsa-miR-7-2-3p87.4622NM_001207051
CLASP1hsa-miR-7-1-3p87.4622NM_001207051
CLASP1hsa-miR-3619-5p87.0304NM_001142273
CLASP1hsa-miR-214-3p86.5733NM_001142273
CLASP1hsa-miR-516a-3p86.432NM_001207051
CLASP1hsa-miR-516b-3p86.432NM_001207051
CLASP1hsa-miR-7162-5p86.432NM_001207051
CLASP1hsa-miR-59185.2783NM_001142273
CLASP1hsa-miR-3184-3p84.6555NM_001207051
CLASP1hsa-miR-205484.4691NM_001207051
CLASP1hsa-miR-6733-5p84.0998NM_001142273
CLASP1hsa-miR-315384.0102NM_001142273
CLASP1hsa-miR-429183.3655NM_001142273
CLASP1hsa-miR-4659b-5p82.6235NM_001207051
CLASP1hsa-miR-320282.3212NM_001207051
CLASP1hsa-miR-3121-5p82.1941NM_001207051
CLASP1hsa-miR-320e81.7155NM_001142273
CLASP1hsa-miR-216a-5p81.1225NM_001207051
CLASP1hsa-miR-447080.9508NM_001142273
CLASP1hsa-miR-4764-5p80.7884NM_001207051
CLASP1hsa-miR-128380.464NM_001142273
CLASP1hsa-miR-797780.2156NM_001207051
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Motifs and transcription factors (TFs) regulating CLASP1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CLASP1transfac_pro__M01253CNOT3 (directAnnotation).
CLASP1transfac_pro__M04817ZBTB33 (directAnnotation).
CLASP1cisbp__M07938E2F1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
CLASP1"Fostamatinib"

DB12010

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."