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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CKAP2

Summary for CKAP2

Gene information	Gene symbol	CKAP2
	Ensembl ID	ENSG00000136108
	Entrez ID	26586
	Gene name	cytoskeleton associated protein 2
	Synonyms	FLJ10749\|LB1\|se20-10\|TMAP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CKAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.41446	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.653342	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.572424	0.00e+00

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Expression of CKAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CKAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CKAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CKAP2	hsa-miR-3609	99.5177	NM_001098525
CKAP2	hsa-miR-548ah-5p	99.5177	NM_001098525
CKAP2	hsa-miR-4738-3p	97.6723	NM_001098525
CKAP2	hsa-miR-4672	94.1146	NM_001098525
CKAP2	hsa-miR-6074	93.6468	NM_001286687
CKAP2	hsa-miR-5689	92.1993	NM_001286687
CKAP2	hsa-miR-514b-5p	91.6645	NM_001286687
CKAP2	hsa-miR-513c-5p	91.6645	NM_001286687
CKAP2	hsa-miR-561-5p	89.7464	NM_001098525
CKAP2	hsa-miR-5590-5p	89.566	NM_001098525
CKAP2	hsa-miR-548av-3p	88.3855	NM_001098525
CKAP2	hsa-miR-3121-3p	87.7619	NM_001098525
CKAP2	hsa-miR-3926	86.8293	NM_001098525
CKAP2	hsa-miR-497-3p	86.1399	NM_001098525
CKAP2	hsa-miR-649	85.6825	NM_001098525
CKAP2	hsa-miR-548aj-3p	85.2392	NM_001098525
CKAP2	hsa-miR-548x-3p	85.2392	NM_001098525
CKAP2	hsa-miR-4306	84.5294	NM_001098525
CKAP2	hsa-miR-561-3p	84.4341	NM_001098525
CKAP2	hsa-miR-6509-5p	83.0495	NM_001098525
CKAP2	hsa-miR-548ae-3p	82.6456	NM_001098525
CKAP2	hsa-miR-548am-3p	82.6456	NM_001098525
CKAP2	hsa-miR-548ah-3p	82.6456	NM_001098525
CKAP2	hsa-miR-548aq-3p	82.6456	NM_001098525
CKAP2	hsa-miR-548j-3p	82.6456	NM_001098525
CKAP2	hsa-miR-4753-5p	81.8189	NM_001098525
CKAP2	hsa-miR-5011-5p	80.9997	NM_001098525

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Motifs and transcription factors (TFs) regulating CKAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CKAP2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CKAP2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CKAP2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CKAP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CKAP2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CKAP2	metacluster_141.4	GLIS2 (directAnnotation).
CKAP2	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CKAP2	transfac_pro__M07483	CXXC1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."