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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CIT

Summary for CIT

Gene information	Gene symbol	CIT
	Ensembl ID	ENSG00000122966
	Entrez ID	11113
	Gene name	citron rho-interacting serine/threonine kinase
	Synonyms	CITK\|CRIK\|KIAA0949\|STK21
	Gene type	protein_coding
	UniProtAcc	O14578

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Dataset with differentially expressed gene: CIT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.68668	6.52e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.317346	9.25e-44

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Expression of CIT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CIT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CIT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CIT	hsa-miR-548an	98.1628	NM_001206999
CIT	hsa-miR-3074-5p	97.3016	NM_001206999
CIT	hsa-miR-7152-5p	95.7243	NM_001206999
CIT	hsa-miR-561-3p	95.5146	NM_001206999
CIT	hsa-miR-4762-5p	94.2937	NM_001206999
CIT	hsa-miR-578	93.7309	NM_001206999
CIT	hsa-miR-6778-5p	93.303	NM_001206999
CIT	hsa-miR-1233-5p	93.303	NM_001206999
CIT	hsa-miR-3922-5p	93.0907	NM_001206999
CIT	hsa-miR-4318	89.9532	NM_001206999
CIT	hsa-miR-29b-2-5p	88.6571	NM_001206999
CIT	hsa-miR-1207-5p	87.7767	NM_001206999
CIT	hsa-miR-1257	87.4159	NM_001206999
CIT	hsa-miR-4800-5p	87.1977	NM_001206999
CIT	hsa-miR-6799-5p	87.0812	NM_001206999
CIT	hsa-miR-6858-5p	86.7286	NM_001206999
CIT	hsa-miR-4689	86.7286	NM_001206999
CIT	hsa-miR-6835-3p	86.6286	NM_001206999
CIT	hsa-miR-545-3p	86.0804	NM_001206999
CIT	hsa-miR-4763-3p	85.8904	NM_001206999
CIT	hsa-miR-802	85.8596	NM_001206999
CIT	hsa-miR-4529-5p	85.3813	NM_001206999
CIT	hsa-miR-5006-5p	85.3261	NM_001206999
CIT	hsa-miR-610	84.407	NM_001206999
CIT	hsa-miR-3926	83.4562	NM_001206999
CIT	hsa-miR-4291	83.2154	NM_001206999
CIT	hsa-miR-4427	83.1407	NM_001206999
CIT	hsa-miR-519a-3p	83.1343	NM_001206999
CIT	hsa-miR-519b-3p	83.1343	NM_001206999
CIT	hsa-miR-519c-3p	83.1343	NM_001206999
CIT	hsa-miR-130b-3p	82.8161	NM_001206999
CIT	hsa-miR-3666	82.8161	NM_001206999
CIT	hsa-miR-643	82.4203	NM_001206999
CIT	hsa-miR-3158-5p	82.2928	NM_001206999
CIT	hsa-miR-4499	82.2268	NM_001206999
CIT	hsa-miR-142-5p	82.1089	NM_001206999
CIT	hsa-miR-5590-3p	82.1089	NM_001206999
CIT	hsa-miR-3059-5p	81.8419	NM_001206999
CIT	hsa-miR-3130-3p	81.3869	NM_001206999
CIT	hsa-miR-4728-5p	81.1655	NM_001206999
CIT	hsa-miR-6785-5p	81.1655	NM_001206999
CIT	hsa-miR-4438	81.0828	NM_001206999
CIT	hsa-miR-9851-5p	80.8779	NM_001206999
CIT	hsa-miR-6879-3p	80.5909	NM_001206999
CIT	hsa-miR-5190	80.5204	NM_001206999
CIT	hsa-miR-7111-3p	80.2159	NM_001206999

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Motifs and transcription factors (TFs) regulating CIT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CIT	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CIT	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
CIT	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CIT	jaspar__MA0079.5	SP1 (directAnnotation).
CIT	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CIT	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."