Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHST2

Summary for CHST2

Gene information	Gene symbol	CHST2
	Ensembl ID	ENSG00000175040
	Entrez ID	9435
	Gene name	carbohydrate sulfotransferase 2
	Synonyms	C6ST
	Gene type	protein_coding
	UniProtAcc	Q9Y4C5

Top

Dataset with differentially expressed gene: CHST2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.01811	1.05e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.332886	3.51e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-0.288204	1.35e-02
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	-0.293083	2.50e-17
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.312818	3.88e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.406664	2.80e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.371547	1.32e-11
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.494674	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.312904	0.00e+00

Top

Expression of CHST2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CHST2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CHST2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHST2	hsa-miR-6867-5p	98.2508	NM_004267
CHST2	hsa-miR-3612	96.8324	NM_004267
CHST2	hsa-miR-650	96.8324	NM_004267
CHST2	hsa-miR-30b-5p	95.7493	NM_004267
CHST2	hsa-miR-30e-5p	95.7493	NM_004267
CHST2	hsa-miR-30d-5p	95.7493	NM_004267
CHST2	hsa-miR-30a-5p	95.7493	NM_004267
CHST2	hsa-miR-30c-5p	95.7493	NM_004267
CHST2	hsa-miR-5001-3p	94.3091	NM_004267
CHST2	hsa-miR-190a-3p	94.0096	NM_004267
CHST2	hsa-miR-875-3p	92.3179	NM_004267
CHST2	hsa-miR-877-3p	92.063	NM_004267
CHST2	hsa-miR-6881-3p	91.4335	NM_004267
CHST2	hsa-miR-6875-3p	91.4094	NM_004267
CHST2	hsa-miR-3158-5p	89.4852	NM_004267
CHST2	hsa-miR-4659b-3p	89.2912	NM_004267
CHST2	hsa-miR-4659a-3p	89.2912	NM_004267
CHST2	hsa-miR-4496	89.0318	NM_004267
CHST2	hsa-miR-3059-5p	88.2787	NM_004267
CHST2	hsa-miR-4699-3p	87.1968	NM_004267
CHST2	hsa-miR-6829-3p	87.0498	NM_004267
CHST2	hsa-miR-6791-3p	87.0498	NM_004267
CHST2	hsa-miR-5004-5p	84.5551	NM_004267
CHST2	hsa-miR-7113-3p	83.7616	NM_004267
CHST2	hsa-miR-4301	83.0828	NM_004267
CHST2	hsa-miR-4443	81.2723	NM_004267
CHST2	hsa-miR-942-5p	81.1962	NM_004267
CHST2	hsa-miR-589-3p	80.0682	NM_004267

Page: 1

Top

Motifs and transcription factors (TFs) regulating CHST2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHST2	hdpi__NFIX	NFIX (directAnnotation).
CHST2	transfac_pro__M03813	POU3F3 (directAnnotation).
CHST2	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
CHST2	hdpi__FOXM1	FOXM1 (directAnnotation).
CHST2	transfac_pro__M04617	ZBTB7A (directAnnotation).
CHST2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CHST2	transfac_pro__M07387	ZBTB7A (directAnnotation).
CHST2	transfac_pro__M07436	WT1 (directAnnotation).
CHST2	transfac_pro__M00716	ZBTB14 (directAnnotation).
CHST2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CHST2	hdpi__HIP2	UBE2K (directAnnotation).
CHST2	transfac_pro__M04893	TAF1 (directAnnotation).
CHST2	transfac_pro__M03876	ZBTB33 (directAnnotation).
CHST2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CHST2	metacluster_116.2	ELK3; ELK3; ETV4 (directAnnotation).
CHST2	transfac_pro__M06408	ZSCAN30 (directAnnotation).
CHST2	transfac_pro__M05915	ZBTB20 (directAnnotation).
CHST2	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTAATAAAN_CAP	ELK3; HOXD12 (directAnnotation).
CHST2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CHST2	metacluster_22.29	NFE2 (directAnnotation).
CHST2	metacluster_22.13	MAFK (inferredBy_Orthology).
CHST2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CHST2	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
CHST2	metacluster_143.13	ZBTB7A (directAnnotation).
CHST2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CHST2	transfac_pro__M06764	ZNF112 (directAnnotation).
CHST2	transfac_pro__M05967	ZFP30 (directAnnotation).
CHST2	taipale_tf_pairs__HOXD12_ETV1_RSCGGAAGTNGTAAAN_CAP	ETV1; HOXD12 (directAnnotation).
CHST2	taipale_cyt_meth__LHX5_NTCGTTAN_FL_meth	LHX5 (directAnnotation).
CHST2	metacluster_161.59	MEOX1 (directAnnotation).
CHST2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
CHST2	transfac_pro__M06604	ZNF524 (directAnnotation).
CHST2	transfac_pro__M06964	SALL4 (inferredBy_Orthology).
CHST2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
CHST2	jaspar__MA1958.1	HOXD12 (directAnnotation).
CHST2	metacluster_161.30	BSX (directAnnotation).
CHST2	metacluster_161.56	HOXB5 (directAnnotation).
CHST2	metacluster_161.32	DLX3 (directAnnotation).
CHST2	taipale_tf_pairs__HOXD4_NNYMATTANN_HT	HOXD4 (directAnnotation).
CHST2	metacluster_161.65	HOXA7 (directAnnotation).
CHST2	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
CHST2	metacluster_161.45	HOXD4 (directAnnotation).
CHST2	metacluster_161.11	VSX2 (directAnnotation).
CHST2	metacluster_161.37	EN1 (directAnnotation).
CHST2	transfac_pro__M05879	ZNF713 (directAnnotation).
CHST2	metacluster_161.41	EVX1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."