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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHST12

Summary for CHST12

Gene information	Gene symbol	CHST12
	Ensembl ID	ENSG00000136213
	Entrez ID	55501
	Gene name	carbohydrate sulfotransferase 12
	Synonyms	C4S-2\|C4ST2
	Gene type	protein_coding
	UniProtAcc	Q9NRB3

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Dataset with differentially expressed gene: CHST12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.4293	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.271445	6.10e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.316055	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.50147	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.280385	3.08e-04
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.298659	0.00e+00

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Expression of CHST12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHST12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHST12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHST12	hsa-miR-101-3p	87.4506	NM_001243794
CHST12	hsa-miR-6779-3p	80.6202	NM_001243794

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Motifs and transcription factors (TFs) regulating CHST12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHST12	transfac_public__M00039	CREB1 (directAnnotation).
CHST12	jaspar__MA0039.4	KLF4 (directAnnotation).
CHST12	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
CHST12	transfac_pro__M04595	SALL2 (directAnnotation).
CHST12	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
CHST12	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
CHST12	jaspar__MA1957.1	ELK1 (directAnnotation).
CHST12	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
CHST12	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
CHST12	metacluster_167.7	IRF8 (inferredBy_Orthology).
CHST12	metacluster_141.4	GLIS2 (directAnnotation).
CHST12	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CHST12	transfac_pro__M05402	BCL6B (directAnnotation).
CHST12	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CHST12	tfdimers__MD00439	ATF1; HOXA13 (directAnnotation).
CHST12	transfac_pro__M06241	ZNF345 (directAnnotation).
CHST12	transfac_pro__M06073	ZNF749 (directAnnotation).
CHST12	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
CHST12	transfac_public__M00040	ATF2 (directAnnotation).
CHST12	transfac_pro__M06724	ZNF331 (directAnnotation).
CHST12	transfac_pro__M05543	ZSCAN12 (inferredBy_Orthology).
CHST12	kznf__ZNF425_Imbeault2017_RP_RCADE	ZNF425 (directAnnotation).
CHST12	swissregulon__hs__OVOL1	OVOL1 (directAnnotation).
CHST12	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
CHST12	taipale_tf_pairs__FOXO1_HOXB13_GWMAACAYMRTAAA_CAP	FOXO1; HOXB13 (directAnnotation).
CHST12	jaspar__MA1944.1	ETV5 (directAnnotation).
CHST12	jaspar__MA1563.2	SOX18 (directAnnotation).
CHST12	transfac_pro__M05566	ZSCAN25 (directAnnotation).
CHST12	metacluster_23.10	FOXO4 (inferredBy_Orthology).
CHST12	taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP	HOXA2; TEAD4 (directAnnotation).
CHST12	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
CHST12	jaspar__MA1509.1	IRF6 (directAnnotation).
CHST12	tfdimers__MD00125	ARID3A; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
CHST12	tfdimers__MD00071	CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; SOX10 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."