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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHST11

Summary for CHST11

Gene information	Gene symbol	CHST11
	Ensembl ID	ENSG00000171310
	Entrez ID	50515
	Gene name	carbohydrate sulfotransferase 11
	Synonyms	C4ST\|C4St-1\|C4ST1\|HSA269537
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CHST11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.82041	3.40e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.546016	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.255246	0.00e+00

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Expression of CHST11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHST11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHST11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHST11	hsa-miR-6867-5p	99.9979	NM_001173982
CHST11	hsa-miR-5692a	99.8031	NM_001173982
CHST11	hsa-miR-126-5p	98.5844	NM_001173982
CHST11	hsa-miR-4795-3p	95.2223	NM_001173982
CHST11	hsa-miR-1299	94.3981	NM_001173982
CHST11	hsa-miR-5689	93.4119	NM_001173982
CHST11	hsa-miR-6810-3p	92.5141	NM_001173982
CHST11	hsa-miR-548c-3p	92.1561	NM_001173982
CHST11	hsa-miR-6893-3p	92.1451	NM_001173982
CHST11	hsa-miR-370-3p	92.1402	NM_001173982
CHST11	hsa-miR-302d-5p	91.715	NM_001173982
CHST11	hsa-miR-302b-5p	91.715	NM_001173982
CHST11	hsa-miR-6734-3p	91.6719	NM_001173982
CHST11	hsa-miR-4254	91.523	NM_001173982
CHST11	hsa-miR-3064-3p	91.3597	NM_001173982
CHST11	hsa-miR-6801-3p	90.2126	NM_001173982
CHST11	hsa-miR-4478	90.0033	NM_001173982
CHST11	hsa-miR-217-5p	89.3943	NM_001173982
CHST11	hsa-miR-4659a-3p	89.3136	NM_001173982
CHST11	hsa-miR-4659b-3p	89.3136	NM_001173982
CHST11	hsa-miR-302a-5p	89.3044	NM_001173982
CHST11	hsa-miR-5093	88.2747	NM_001173982
CHST11	hsa-miR-6807-3p	88.2104	NM_001173982
CHST11	hsa-miR-875-3p	86.9484	NM_001173982
CHST11	hsa-miR-1197	86.7648	NM_001173982
CHST11	hsa-miR-3182	86.6589	NM_001173982
CHST11	hsa-miR-6881-3p	86.154	NM_001173982
CHST11	hsa-miR-4507	85.8938	NM_001173982
CHST11	hsa-miR-3940-5p	85.8938	NM_001173982
CHST11	hsa-miR-3189-3p	85.3432	NM_001173982
CHST11	hsa-miR-6729-3p	84.8166	NM_001173982
CHST11	hsa-miR-6839-3p	84.6221	NM_001173982
CHST11	hsa-miR-6847-3p	83.5135	NM_001173982
CHST11	hsa-miR-4786-5p	83.2872	NM_001173982
CHST11	hsa-miR-1226-3p	82.5993	NM_001173982
CHST11	hsa-miR-516b-5p	82.4242	NM_001173982
CHST11	hsa-miR-95-5p	82.2777	NM_001173982
CHST11	hsa-miR-3667-3p	82.0316	NM_001173982
CHST11	hsa-miR-766-5p	81.3048	NM_001173982
CHST11	hsa-miR-3929	81.2124	NM_001173982

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Motifs and transcription factors (TFs) regulating CHST11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHST11	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
CHST11	cisbp__M08198	ELF1 (directAnnotation).
CHST11	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CHST11	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CHST11	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CHST11	transfac_pro__M01122	ZNF219 (directAnnotation).
CHST11	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CHST11	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CHST11	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CHST11	jaspar__MA1721.1	ZNF93 (directAnnotation).
CHST11	cisbp__M00341	PAX6 (directAnnotation).
CHST11	transfac_pro__M01199	TRIM28 (directAnnotation).
CHST11	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
CHST11	transfac_pro__M01303	SP1 (directAnnotation).
CHST11	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CHST11	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CHST11	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."