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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CHP1

Summary for CHP1

Gene information	Gene symbol	CHP1
	Ensembl ID	ENSG00000187446
	Entrez ID	11261
	Gene name	calcineurin like EF-hand protein 1
	Synonyms	CHP\|p22\|p24\|Sid470p\|SLC9A1BP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CHP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.267378	9.39e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.323625	2.73e-16
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.444888	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.519356	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.414167	1.51e-26
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.384657	9.73e-37

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Expression of CHP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHP1	hsa-miR-4480	99.4223	NM_007236
CHP1	hsa-miR-3714	96.5185	NM_007236
CHP1	hsa-miR-6727-3p	94.5014	NM_007236
CHP1	hsa-miR-124-3p	93.7835	NM_007236
CHP1	hsa-miR-506-3p	93.7835	NM_007236
CHP1	hsa-miR-186-5p	92.9349	NM_007236
CHP1	hsa-miR-4724-5p	92.8273	NM_007236
CHP1	hsa-miR-6856-3p	92.6466	NM_007236
CHP1	hsa-miR-4722-3p	92.4804	NM_007236
CHP1	hsa-miR-3145-3p	91.2704	NM_007236
CHP1	hsa-miR-5702	91.1047	NM_007236
CHP1	hsa-miR-5580-5p	90.8492	NM_007236
CHP1	hsa-miR-3613-3p	90.5151	NM_007236
CHP1	hsa-miR-5582-5p	90.501	NM_007236
CHP1	hsa-miR-616-5p	87.9034	NM_007236
CHP1	hsa-miR-371b-5p	87.9034	NM_007236
CHP1	hsa-miR-373-5p	87.9034	NM_007236
CHP1	hsa-miR-644a	86.9176	NM_007236
CHP1	hsa-miR-6134	86.8384	NM_007236
CHP1	hsa-miR-887-5p	85.9674	NM_007236
CHP1	hsa-miR-3188	85.8971	NM_007236
CHP1	hsa-miR-1304-5p	85.4487	NM_007236
CHP1	hsa-miR-204-5p	85.2703	NM_007236
CHP1	hsa-miR-211-5p	85.2703	NM_007236
CHP1	hsa-miR-890	85.2376	NM_007236
CHP1	hsa-miR-337-3p	85.0255	NM_007236
CHP1	hsa-miR-2116-5p	84.473	NM_007236
CHP1	hsa-miR-4729	83.9367	NM_007236
CHP1	hsa-miR-145-5p	82.3694	NM_007236
CHP1	hsa-miR-5195-3p	82.3694	NM_007236
CHP1	hsa-miR-30c-2-3p	81.8275	NM_007236
CHP1	hsa-miR-6788-5p	81.8275	NM_007236
CHP1	hsa-miR-30c-1-3p	81.8275	NM_007236
CHP1	hsa-miR-4725-3p	81.7519	NM_007236
CHP1	hsa-miR-6780b-5p	81.7519	NM_007236
CHP1	hsa-miR-200a-3p	81.3419	NM_007236
CHP1	hsa-miR-141-3p	81.3419	NM_007236
CHP1	hsa-miR-3085-5p	81.2518	NM_007236
CHP1	hsa-miR-6761-5p	81.219	NM_007236
CHP1	hsa-miR-4728-5p	81.0518	NM_007236
CHP1	hsa-miR-4277	80.8111	NM_007236
CHP1	hsa-miR-4789-5p	80.729	NM_007236
CHP1	hsa-miR-4261	80.2056	NM_007236

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Motifs and transcription factors (TFs) regulating CHP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHP1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CHP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CHP1	transfac_pro__M05791	ZNF517 (directAnnotation).
CHP1	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
CHP1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CHP1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CHP1	transfac_pro__M06063	ZNF99 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CHP1	"Calcium citrate"	DB11093	small molecule
CHP1	"Calcium phosphate dihydrate"	DB14481	small molecule
CHP1	"Calcium Phosphate"	DB11348	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."