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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHGA

Summary for CHGA

Gene information	Gene symbol	CHGA
	Ensembl ID	ENSG00000276781
	Entrez ID	1113
	Gene name	chromogranin A
	Synonyms	PHE5\|PHES
	Gene type	protein_coding
	UniProtAcc	P10645

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Dataset with differentially expressed gene: CHGA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-1.40864	0.00e+00

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Expression of CHGA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHGA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHGA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHGA	hsa-miR-6799-3p	97.151	NM_001275
CHGA	hsa-miR-3173-5p	96.6595	NM_001275
CHGA	hsa-miR-4433a-3p	91.1026	NM_001275
CHGA	hsa-miR-4685-5p	89.609	NM_001275
CHGA	hsa-miR-6837-5p	87.5979	NM_001275
CHGA	hsa-miR-5191	87.2157	NM_001275
CHGA	hsa-miR-6721-5p	85.0588	NM_001275
CHGA	hsa-miR-6882-3p	84.6372	NM_001275
CHGA	hsa-miR-6811-3p	82.9236	NM_001275
CHGA	hsa-miR-6508-5p	80.7889	NM_001275

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Motifs and transcription factors (TFs) regulating CHGA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHGA	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
CHGA	transfac_pro__M02843	BBX (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."