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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHFR

Summary for CHFR

Gene information	Gene symbol	CHFR
	Ensembl ID	ENSG00000072609
	Entrez ID	55743
	Gene name	checkpoint with forkhead and ring finger domains
	Synonyms	FLJ10796\|RNF196
	Gene type	protein_coding
	UniProtAcc	Q96EP1

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Dataset with differentially expressed gene: CHFR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.477663	8.31e-04

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Expression of CHFR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHFR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHFR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHFR	hsa-miR-26a-5p	94.5533	NM_001161344
CHFR	hsa-miR-1297	94.5533	NM_001161344
CHFR	hsa-miR-26b-5p	94.1074	NM_001161344
CHFR	hsa-miR-4465	94.0221	NM_001161344
CHFR	hsa-miR-3065-5p	93.9172	NM_001161346
CHFR	hsa-miR-335-5p	93.0121	NM_001161344
CHFR	hsa-miR-4324	92.9838	NM_001161344
CHFR	hsa-miR-4729	92.501	NM_001161344
CHFR	hsa-miR-1200	92.0307	NM_001161344
CHFR	hsa-miR-7850-5p	91.4598	NM_001161346
CHFR	hsa-miR-577	90.8511	NM_001161346
CHFR	hsa-miR-7159-5p	89.6216	NM_001161346
CHFR	hsa-miR-498-5p	87.8304	NM_001161344
CHFR	hsa-miR-548p	87.5551	NM_001161346
CHFR	hsa-miR-1253	87.2712	NM_001161344
CHFR	hsa-miR-548v	87.2376	NM_001161346
CHFR	hsa-miR-378a-5p	85.6243	NM_001161344
CHFR	hsa-miR-4696	85.4848	NM_001161344
CHFR	hsa-miR-548f-5p	85.1502	NM_001161346
CHFR	hsa-miR-548aj-5p	85.1502	NM_001161346
CHFR	hsa-miR-548x-5p	85.1502	NM_001161346
CHFR	hsa-miR-548g-5p	85.1502	NM_001161346
CHFR	hsa-miR-2113	85.1306	NM_001161344
CHFR	hsa-miR-758-3p	84.7275	NM_001161346
CHFR	hsa-miR-5697	84.5679	NM_001161344
CHFR	hsa-miR-593-3p	83.3937	NM_001161346
CHFR	hsa-miR-498-3p	83.2287	NM_001161344
CHFR	hsa-miR-4742-3p	82.2224	NM_001161346
CHFR	hsa-miR-544b	81.5167	NM_001161344
CHFR	hsa-miR-488-5p	81.3555	NM_001161344
CHFR	hsa-miR-451b	81.3302	NM_001161344

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Motifs and transcription factors (TFs) regulating CHFR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHFR	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).
CHFR	metacluster_72.10	ZNF697 (directAnnotation).
CHFR	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
CHFR	transfac_pro__M06277	ZNF404 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."