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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHD7

Summary for CHD7

Gene information	Gene symbol	CHD7
	Ensembl ID	ENSG00000171316
	Entrez ID	55636
	Gene name	chromodomain helicase DNA binding protein 7
	Synonyms	CRG\|FLJ20357\|FLJ20361\|KIAA1416
	Gene type	protein_coding
	UniProtAcc	Q9P2D1

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Dataset with differentially expressed gene: CHD7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.490767	2.25e-02
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.271557	0.00e+00

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Expression of CHD7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHD7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHD7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHD7	hsa-miR-545-3p	96.8075	NM_001316690
CHD7	hsa-miR-4474-3p	95.0189	NM_017780
CHD7	hsa-miR-190b-5p	94.9338	NM_001316690
CHD7	hsa-miR-190a-5p	94.9338	NM_001316690
CHD7	hsa-miR-3613-3p	94.8361	NM_017780
CHD7	hsa-miR-548e-5p	94.5891	NM_017780
CHD7	hsa-miR-6501-3p	93.657	NM_001316690
CHD7	hsa-miR-759	93.4405	NM_017780
CHD7	hsa-miR-513c-3p	93.3885	NM_017780
CHD7	hsa-miR-513a-3p	93.3885	NM_017780
CHD7	hsa-miR-513a-5p	93.1059	NM_001316690
CHD7	hsa-miR-6867-5p	92.9738	NM_001316690
CHD7	hsa-miR-1825	92.9427	NM_001316690
CHD7	hsa-miR-6875-3p	92.6636	NM_001316690
CHD7	hsa-miR-372-5p	92.5734	NM_017780
CHD7	hsa-miR-5003-5p	92.1172	NM_001316690
CHD7	hsa-miR-1263	91.8121	NM_001316690
CHD7	hsa-miR-6766-3p	91.7533	NM_001316690
CHD7	hsa-miR-4782-3p	91.7533	NM_001316690
CHD7	hsa-miR-219a-5p	91.7533	NM_001316690
CHD7	hsa-miR-3606-3p	91.4363	NM_017780
CHD7	hsa-miR-30a-5p	89.6248	NM_017780
CHD7	hsa-miR-30d-5p	89.6248	NM_017780
CHD7	hsa-miR-30b-5p	89.6248	NM_017780
CHD7	hsa-miR-30c-5p	89.6248	NM_017780
CHD7	hsa-miR-30e-5p	89.6248	NM_017780
CHD7	hsa-miR-369-3p	88.4236	NM_017780
CHD7	hsa-miR-6845-3p	87.3139	NM_017780
CHD7	hsa-miR-200a-5p	87.0264	NM_001316690
CHD7	hsa-miR-200b-5p	87.0264	NM_001316690
CHD7	hsa-miR-3974	86.7629	NM_001316690
CHD7	hsa-miR-5692a	85.4209	NM_001316690
CHD7	hsa-miR-27a-3p	85.2561	NM_001316690
CHD7	hsa-miR-27b-3p	85.2561	NM_001316690
CHD7	hsa-miR-9985	85.2561	NM_001316690
CHD7	hsa-miR-148a-3p	83.5648	NM_001316690
CHD7	hsa-miR-152-3p	83.5648	NM_001316690
CHD7	hsa-miR-148b-3p	83.5648	NM_001316690
CHD7	hsa-miR-6883-3p	82.1518	NM_001316690
CHD7	hsa-miR-514b-3p	80.9251	NM_017780
CHD7	hsa-miR-514a-3p	80.9251	NM_017780
CHD7	hsa-miR-4764-5p	80.792	NM_017780
CHD7	hsa-miR-7108-5p	80.7208	NM_017780
CHD7	hsa-miR-6759-3p	80.3002	NM_001316690
CHD7	hsa-miR-599	80.0628	NM_001316690

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Motifs and transcription factors (TFs) regulating CHD7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHD7	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CHD7	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CHD7	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
CHD7	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CHD7	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CHD7	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
CHD7	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CHD7	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CHD7	metacluster_3.14	WT1; WT1 (directAnnotation).
CHD7	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CHD7	cisbp__M07938	E2F1 (directAnnotation).
CHD7	tfdimers__MD00292	HLTF; POU5F1 (directAnnotation).
CHD7	metacluster_84.16	RARB (directAnnotation).
CHD7	hdpi__PURG	PURG (directAnnotation).
CHD7	transfac_pro__M06692	PRDM10 (directAnnotation).
CHD7	swissregulon__hs__ZNF691	ZNF691 (directAnnotation).
CHD7	transfac_pro__M06357	ZNF629 (inferredBy_Orthology).
CHD7	kznf__ZNF33A_Najafabadi2015_ChIP-seq	ZNF33A (directAnnotation).
CHD7	transfac_pro__M06968	ZNF467 (inferredBy_Orthology).
CHD7	swissregulon__hs__DBP	DBP (directAnnotation).
CHD7	transfac_pro__M12556	ETV4 (directAnnotation).
CHD7	metacluster_84.15	RARB (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."