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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHD3

Summary for CHD3

Gene information	Gene symbol	CHD3
	Ensembl ID	ENSG00000170004
	Entrez ID	1107
	Gene name	chromodomain helicase DNA binding protein 3
	Synonyms	Mi-2a\|Mi2-ALPHA\|ZFH
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CHD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.025	1.28e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.342469	1.61e-22
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.34293	0.00e+00

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Expression of CHD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHD3	hsa-miR-6749-3p	97.054	NM_001005271
CHD3	hsa-miR-6739-5p	95.7943	NM_001005271
CHD3	hsa-miR-6733-5p	95.7943	NM_001005271
CHD3	hsa-miR-4688	93.1361	NM_005852
CHD3	hsa-miR-3153	93.1058	NM_001005271
CHD3	hsa-miR-532-3p	92.5688	NM_001005271
CHD3	hsa-miR-6743-5p	91.7389	NM_005852
CHD3	hsa-miR-4635	91.5887	NM_005852
CHD3	hsa-miR-98-3p	91.2191	NM_001005271
CHD3	hsa-let-7a-3p	91.2191	NM_001005271
CHD3	hsa-let-7b-3p	91.2191	NM_001005271
CHD3	hsa-let-7f-1-3p	91.2191	NM_001005271
CHD3	hsa-miR-1199-5p	87.9059	NM_001005271
CHD3	hsa-miR-6751-3p	87.7316	NM_001005271
CHD3	hsa-miR-10401-5p	86.1574	NM_005852
CHD3	hsa-miR-4268	86.0168	NM_001005271
CHD3	hsa-miR-92a-2-5p	84.4425	NM_005852
CHD3	hsa-miR-6780b-5p	84.4035	NM_005852
CHD3	hsa-miR-4725-3p	84.4035	NM_005852
CHD3	hsa-miR-7-5p	83.7074	NM_001005271
CHD3	hsa-miR-4455	83.546	NM_005852
CHD3	hsa-miR-7152-3p	83.1317	NM_001005271
CHD3	hsa-miR-1226-3p	82.9954	NM_001005271
CHD3	hsa-miR-3136-3p	82.7077	NM_005852
CHD3	hsa-miR-6887-3p	82.6642	NM_001005271
CHD3	hsa-miR-3183	82.6247	NM_001005271
CHD3	hsa-miR-6769b-3p	82.3787	NM_001005271
CHD3	hsa-miR-4723-3p	82.3787	NM_001005271
CHD3	hsa-miR-890	81.4127	NM_005852
CHD3	hsa-miR-5088-3p	80.8951	NM_001005271
CHD3	hsa-miR-7155-3p	80.5944	NM_005852
CHD3	hsa-miR-6763-5p	80.2185	NM_005852
CHD3	hsa-miR-6892-3p	80.0776	NM_005852

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Motifs and transcription factors (TFs) regulating CHD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHD3	transfac_pro__M04617	ZBTB7A (directAnnotation).
CHD3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CHD3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CHD3	transfac_pro__M07387	ZBTB7A (directAnnotation).
CHD3	transfac_pro__M07436	WT1 (directAnnotation).
CHD3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CHD3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CHD3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CHD3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CHD3	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
CHD3	cisbp__M00249	WT1 (directAnnotation).
CHD3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."