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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHCHD3

Summary for CHCHD3

Gene information	Gene symbol	CHCHD3
	Ensembl ID	ENSG00000106554
	Entrez ID	54927
	Gene name	coiled-coil-helix-coiled-coil-helix domain containing 3
	Synonyms	FLJ20420\|Mic19\|MICOS19\|MINOS3\|PPP1R22
	Gene type	protein_coding
	UniProtAcc	Q9NX63

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Dataset with differentially expressed gene: CHCHD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.276417	4.39e-18
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.291865	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.318167	7.92e-16
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.765245	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.5782	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.262822	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.508665	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.570847	5.02e-35
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.484515	3.80e-35
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.531455	7.66e-33
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.636637	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.30298	1.15e-04
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.39269	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.351849	0.00e+00

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Expression of CHCHD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHCHD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHCHD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHCHD3	hsa-miR-942-5p	97.3495	NM_001317177
CHCHD3	hsa-miR-6718-5p	97.2418	NM_017812
CHCHD3	hsa-miR-203b-5p	97.2418	NM_017812
CHCHD3	hsa-miR-518c-5p	96.6412	NM_001317177
CHCHD3	hsa-miR-4753-3p	95.6687	NM_017812
CHCHD3	hsa-miR-3174	94.2993	NM_017812
CHCHD3	hsa-miR-1279	93.7634	NM_017812
CHCHD3	hsa-miR-6845-3p	92.2952	NM_017812
CHCHD3	hsa-miR-4428	92.0343	NM_001317177
CHCHD3	hsa-miR-548ax	91.5272	NM_017812
CHCHD3	hsa-miR-548ao-5p	91.5272	NM_017812
CHCHD3	hsa-miR-6128	91.5162	NM_001317177
CHCHD3	hsa-miR-3529-3p	90.2612	NM_001317178
CHCHD3	hsa-miR-4460	88.7682	NM_017812
CHCHD3	hsa-miR-4795-3p	87.6535	NM_001317177
CHCHD3	hsa-miR-6895-3p	87.4615	NM_017812
CHCHD3	hsa-miR-1299	87.4294	NM_001317177
CHCHD3	hsa-miR-1277-5p	85.4453	NM_001317177
CHCHD3	hsa-miR-6740-3p	85.254	NM_017812
CHCHD3	hsa-miR-330-5p	83.6457	NM_001317177
CHCHD3	hsa-miR-6824-3p	83.6457	NM_001317177
CHCHD3	hsa-miR-6764-3p	83.6457	NM_001317177
CHCHD3	hsa-miR-6731-5p	83.2189	NM_001317178
CHCHD3	hsa-miR-8085	83.2189	NM_001317178
CHCHD3	hsa-miR-1285-5p	83.1554	NM_017812
CHCHD3	hsa-miR-5585-3p	82.9792	NM_017812
CHCHD3	hsa-miR-12127	82.2128	NM_017812
CHCHD3	hsa-miR-6515-3p	81.3091	NM_017812
CHCHD3	hsa-miR-3938	80.7831	NM_001317178
CHCHD3	hsa-miR-130a-5p	80.3257	NM_017812
CHCHD3	hsa-miR-875-3p	80.2541	NM_001317177

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Motifs and transcription factors (TFs) regulating CHCHD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHCHD3	hdpi__ETV4	ETV4 (directAnnotation).
CHCHD3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CHCHD3	metacluster_33.5	MTF1 (inferredBy_Orthology).
CHCHD3	jaspar__MA1934.1	FIGLA (directAnnotation).
CHCHD3	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
CHCHD3	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
CHCHD3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CHCHD3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CHCHD3	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
CHCHD3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CHCHD3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CHCHD3	jaspar__MA1122.1	TFDP1 (directAnnotation).
CHCHD3	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CHCHD3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CHCHD3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CHCHD3	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CHCHD3	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CHCHD3	cisbp__M02645	ETS1 (directAnnotation).
CHCHD3	cisbp__M08198	ELF1 (directAnnotation).
CHCHD3	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
CHCHD3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CHCHD3	transfac_pro__M05432	ZSCAN18 (directAnnotation).
CHCHD3	transfac_pro__M04826	EP300 (directAnnotation).
CHCHD3	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CHCHD3	hdpi__ELF2	ELF2 (directAnnotation).
CHCHD3	metacluster_183.4	ETS1 (inferredBy_Orthology).
CHCHD3	transfac_pro__M04862	NRF1 (directAnnotation).
CHCHD3	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
CHCHD3	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
CHCHD3	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
CHCHD3	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
CHCHD3	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."