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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHAC1

Summary for CHAC1

Gene information	Gene symbol	CHAC1
	Ensembl ID	ENSG00000128965
	Entrez ID	79094
	Gene name	ChaC glutathione specific gamma-glutamylcyclotransferase 1
	Synonyms	MGC4504
	Gene type	protein_coding
	UniProtAcc	Q9BUX1

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Dataset with differentially expressed gene: CHAC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.5977	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.564066	0.00e+00

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Expression of CHAC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHAC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHAC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHAC1	hsa-miR-5697	98.3862	NM_001142776
CHAC1	hsa-miR-16-5p	95.2812	NM_001142776
CHAC1	hsa-miR-15b-5p	95.2812	NM_001142776
CHAC1	hsa-miR-15a-5p	95.2812	NM_001142776
CHAC1	hsa-miR-195-5p	95.2812	NM_001142776
CHAC1	hsa-miR-6840-3p	93.8533	NM_001142776
CHAC1	hsa-miR-6838-5p	93.6049	NM_001142776
CHAC1	hsa-miR-424-5p	92.8262	NM_001142776
CHAC1	hsa-miR-497-5p	92.8262	NM_001142776
CHAC1	hsa-miR-1297	92.6743	NM_001142776
CHAC1	hsa-miR-26a-5p	92.0444	NM_001142776
CHAC1	hsa-miR-26b-5p	92.0444	NM_001142776
CHAC1	hsa-miR-4465	90.9304	NM_001142776
CHAC1	hsa-miR-3115	90.8262	NM_001142776
CHAC1	hsa-miR-6837-5p	88.7533	NM_001142776
CHAC1	hsa-miR-1207-5p	87.6608	NM_001142776
CHAC1	hsa-miR-4685-5p	87.47	NM_001142776
CHAC1	hsa-miR-4763-3p	87.3513	NM_001142776
CHAC1	hsa-miR-3918	85.7204	NM_001142776
CHAC1	hsa-miR-4311	84.6814	NM_001142776
CHAC1	hsa-miR-1324	82.4971	NM_001142776
CHAC1	hsa-miR-4524a-5p	80.6092	NM_001142776
CHAC1	hsa-miR-4524b-5p	80.6092	NM_001142776
CHAC1	hsa-miR-767-3p	80.2486	NM_001142776

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Motifs and transcription factors (TFs) regulating CHAC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHAC1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CHAC1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
CHAC1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CHAC1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
CHAC1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CHAC1	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
CHAC1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CHAC1	cisbp__M01863	ZNF711 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."