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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CFL2

Summary for CFL2

Gene information	Gene symbol	CFL2
	Ensembl ID	ENSG00000165410
	Entrez ID	1073
	Gene name	cofilin 2
	Synonyms	NEM7
	Gene type	protein_coding
	UniProtAcc	Q9Y281

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Dataset with differentially expressed gene: CFL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.264544	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.0504	0.00e+00

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Expression of CFL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CFL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CFL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CFL2	hsa-miR-200b-3p	98.9506	NM_001243645
CFL2	hsa-miR-200c-3p	98.9506	NM_001243645
CFL2	hsa-miR-429	98.9506	NM_001243645
CFL2	hsa-miR-3613-3p	98.8404	NM_001243645
CFL2	hsa-miR-5590-5p	98.7352	NM_001243645
CFL2	hsa-miR-20a-5p	98.5844	NM_001243645
CFL2	hsa-miR-106a-5p	98.5844	NM_001243645
CFL2	hsa-miR-106b-5p	98.5844	NM_001243645
CFL2	hsa-miR-526b-3p	98.5844	NM_001243645
CFL2	hsa-miR-8084	98.4169	NM_001243645
CFL2	hsa-miR-93-5p	98.2526	NM_001243645
CFL2	hsa-miR-17-5p	98.2526	NM_001243645
CFL2	hsa-miR-20b-5p	98.2526	NM_001243645
CFL2	hsa-miR-519d-3p	98.2526	NM_001243645
CFL2	hsa-miR-1468-3p	98.1676	NM_001243645
CFL2	hsa-miR-4776-3p	97.9032	NM_001243645
CFL2	hsa-miR-548n	97.6576	NM_001243645
CFL2	hsa-miR-3910	97.5248	NM_001243645
CFL2	hsa-miR-3163	97.3785	NM_001243645
CFL2	hsa-miR-9-3p	97.1563	NM_001243645
CFL2	hsa-miR-520f-3p	96.8743	NM_001243645
CFL2	hsa-miR-19b-1-5p	96.8531	NM_001243645
CFL2	hsa-miR-19a-5p	96.8531	NM_001243645
CFL2	hsa-miR-19b-2-5p	96.8531	NM_001243645
CFL2	hsa-miR-450b-5p	96.6178	NM_001243645
CFL2	hsa-miR-548aw	96.5292	NM_001243645
CFL2	hsa-miR-5692a	96.4516	NM_001243645
CFL2	hsa-miR-671-5p	96.2357	NM_001243645
CFL2	hsa-miR-30c-5p	95.7077	NM_001243645
CFL2	hsa-miR-30a-5p	95.7077	NM_001243645
CFL2	hsa-miR-30e-5p	95.7077	NM_001243645
CFL2	hsa-miR-30b-5p	95.7077	NM_001243645
CFL2	hsa-miR-30d-5p	95.7077	NM_001243645
CFL2	hsa-miR-33a-3p	94.8495	NM_001243645
CFL2	hsa-miR-616-5p	94.6833	NM_001243645
CFL2	hsa-miR-7856-5p	94.0335	NM_001243645
CFL2	hsa-miR-4255	93.5824	NM_001243645
CFL2	hsa-miR-373-5p	93.3751	NM_001243645
CFL2	hsa-miR-371b-5p	93.3751	NM_001243645
CFL2	hsa-miR-369-3p	93.2634	NM_001243645
CFL2	hsa-miR-508-3p	92.998	NM_001243645
CFL2	hsa-miR-548t-5p	92.6605	NM_001243645
CFL2	hsa-miR-548az-5p	92.6605	NM_001243645
CFL2	hsa-miR-3148	92.5324	NM_001243645
CFL2	hsa-miR-548f-5p	91.1321	NM_001243645
CFL2	hsa-miR-548x-5p	91.1321	NM_001243645
CFL2	hsa-miR-548aj-5p	91.1321	NM_001243645
CFL2	hsa-miR-548g-5p	91.1321	NM_001243645
CFL2	hsa-miR-4480	90.4907	NM_001243645
CFL2	hsa-miR-545-5p	90.4561	NM_001243645

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Motifs and transcription factors (TFs) regulating CFL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CFL2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CFL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CFL2	transfac_pro__M07397	ZNF148 (directAnnotation).
CFL2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CFL2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CFL2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CFL2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CFL2	metacluster_7.13	ZFX (directAnnotation).
CFL2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CFL2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CFL2	transfac_pro__M01175	ZBTB7B (directAnnotation).
CFL2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CFL2	tfdimers__MD00151	CHURC1 (directAnnotation).
CFL2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CFL2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CFL2	transfac_pro__M01303	SP1 (directAnnotation).
CFL2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CFL2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CFL2	transfac_pro__M02090	E2F4 (directAnnotation).
CFL2	transfac_pro__M01714	KLF15 (directAnnotation).
CFL2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CFL2	transfac_pro__M02089	E2F3 (directAnnotation).
CFL2	metacluster_3.14	WT1; WT1 (directAnnotation).
CFL2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CFL2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CFL2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CFL2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CFL2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CFL2	cisbp__M07938	E2F1 (directAnnotation).
CFL2	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
CFL2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CFL2	transfac_pro__M07436	WT1 (directAnnotation).
CFL2	transfac_pro__M02281	SP1 (directAnnotation).
CFL2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CFL2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CFL2	transfac_pro__M02898	SMAD3 (directAnnotation).
CFL2	transfac_public__M00491	PATZ1 (directAnnotation).
CFL2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CFL2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CFL2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CFL2	transfac_pro__M04866	HDAC2 (directAnnotation).
CFL2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CFL2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CFL2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
CFL2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."