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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CFAP97

Summary for CFAP97

Gene information	Gene symbol	CFAP97
	Ensembl ID	ENSG00000164323
	Entrez ID	57587
	Gene name	cilia and flagella associated protein 97
	Synonyms	DKFZp434F1728\|hmw\|KIAA1430
	Gene type	protein_coding
	UniProtAcc	Q9P2B7

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Dataset with differentially expressed gene: CFAP97

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.570708	2.77e-34
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.552651	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.388766	0.00e+00

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Expression of CFAP97 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CFAP97

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CFAP97

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CFAP97	hsa-miR-5011-5p	100	NM_020827
CFAP97	hsa-miR-190a-3p	99.9973	NM_020827
CFAP97	hsa-miR-4263	98.4659	NM_020827
CFAP97	hsa-miR-3163	94.9518	NM_020827
CFAP97	hsa-miR-570-3p	93.9121	NM_020827
CFAP97	hsa-miR-4682	93.6679	NM_001292033
CFAP97	hsa-miR-664a-3p	92.2985	NM_020827
CFAP97	hsa-miR-203a-3p	91.377	NM_020827
CFAP97	hsa-miR-3613-3p	91.1242	NM_020827
CFAP97	hsa-miR-944	90.5002	NM_020827
CFAP97	hsa-miR-942-5p	90.465	NM_020827
CFAP97	hsa-miR-4803	89.351	NM_020827
CFAP97	hsa-miR-4282	89.0651	NM_020827
CFAP97	hsa-miR-4672	88.7519	NM_020827
CFAP97	hsa-miR-340-5p	88.4768	NM_020827
CFAP97	hsa-miR-376a-3p	88.3849	NM_020827
CFAP97	hsa-miR-376b-3p	88.3849	NM_020827
CFAP97	hsa-miR-4287	88.2136	NM_001292033
CFAP97	hsa-miR-4685-3p	88.2136	NM_001292033
CFAP97	hsa-miR-6516-5p	88.1467	NM_020827
CFAP97	hsa-miR-3148	88.0618	NM_001292033
CFAP97	hsa-miR-3168	87.0243	NM_020827
CFAP97	hsa-miR-4427	86.5628	NM_020827
CFAP97	hsa-miR-30b-5p	86.11	NM_001292033
CFAP97	hsa-miR-30e-5p	86.11	NM_001292033
CFAP97	hsa-miR-30d-5p	86.11	NM_001292033
CFAP97	hsa-miR-30c-5p	86.11	NM_001292033
CFAP97	hsa-miR-30a-5p	86.11	NM_001292033
CFAP97	hsa-miR-548c-3p	85.5581	NM_020827
CFAP97	hsa-miR-6868-3p	85.1083	NM_020827
CFAP97	hsa-miR-6074	84.5284	NM_020827
CFAP97	hsa-miR-576-5p	84.2036	NM_020827
CFAP97	hsa-miR-1827	83.9323	NM_001292033
CFAP97	hsa-miR-421	83.9162	NM_001292033
CFAP97	hsa-miR-154-5p	82.8151	NM_020827
CFAP97	hsa-miR-3973	82.2118	NM_020827
CFAP97	hsa-miR-1253	82.0276	NM_020827
CFAP97	hsa-miR-4683	81.9395	NM_001292033
CFAP97	hsa-miR-410-3p	81.8918	NM_020827
CFAP97	hsa-miR-6882-5p	80.7186	NM_020827

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Motifs and transcription factors (TFs) regulating CFAP97

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CFAP97	metacluster_135.11	NR2C2 (directAnnotation).
CFAP97	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CFAP97	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CFAP97	metacluster_7.13	ZFX (directAnnotation).
CFAP97	cisbp__M00968	MTF2 (directAnnotation).
CFAP97	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CFAP97	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CFAP97	metacluster_198.3	ZFP64 (directAnnotation).
CFAP97	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CFAP97	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CFAP97	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CFAP97	cisbp__M00788	ZFY (inferredBy_Orthology).
CFAP97	hdpi__ZNF304	ZNF304 (directAnnotation).
CFAP97	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CFAP97	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CFAP97	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CFAP97	transfac_pro__M01199	TRIM28 (directAnnotation).
CFAP97	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CFAP97	metacluster_151.2	ZNF23 (directAnnotation).
CFAP97	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CFAP97	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CFAP97	transfac_pro__M03806	ZBTB7C (directAnnotation).
CFAP97	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CFAP97	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CFAP97	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CFAP97	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CFAP97	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CFAP97	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CFAP97	hdpi__ETV4	ETV4 (directAnnotation).
CFAP97	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CFAP97	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
CFAP97	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."