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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CERS2

Summary for CERS2

Gene information	Gene symbol	CERS2
	Ensembl ID	ENSG00000143418
	Entrez ID	29956
	Gene name	ceramide synthase 2
	Synonyms	FLJ10243\|LASS2\|SP260
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CERS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.45954	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.493449	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.279407	5.48e-18
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.25069	1.58e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.352422	1.89e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.558768	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.256512	1.27e-06
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.488597	1.26e-44
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.917445	0.00e+00

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Expression of CERS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CERS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CERS2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CERS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CERS2	hsa-miR-4739	97.0741	NM_022075
CERS2	hsa-miR-1321	97.0741	NM_022075
CERS2	hsa-miR-4756-5p	97.0741	NM_022075
CERS2	hsa-miR-6760-5p	96.3036	NM_022075
CERS2	hsa-miR-101-3p	96.0801	NM_022075
CERS2	hsa-miR-5008-5p	94.8943	NM_022075
CERS2	hsa-miR-96-5p	94.6536	NM_022075
CERS2	hsa-miR-182-5p	94.6536	NM_022075
CERS2	hsa-miR-8066	93.7926	NM_022075
CERS2	hsa-miR-1271-5p	92.2898	NM_022075
CERS2	hsa-miR-12133	92.2898	NM_022075
CERS2	hsa-miR-548an	92.1114	NM_022075
CERS2	hsa-miR-4659b-5p	91.5598	NM_022075
CERS2	hsa-miR-599	90.3669	NM_022075
CERS2	hsa-miR-212-5p	89.5154	NM_022075
CERS2	hsa-miR-6130	89.3658	NM_022075
CERS2	hsa-miR-6127	89.3658	NM_022075
CERS2	hsa-miR-6133	89.3658	NM_022075
CERS2	hsa-miR-6129	89.3658	NM_022075
CERS2	hsa-miR-4510	89.3658	NM_022075
CERS2	hsa-miR-5692a	89.0132	NM_022075
CERS2	hsa-miR-2355-5p	87.3979	NM_022075
CERS2	hsa-miR-4659a-5p	87.1999	NM_022075
CERS2	hsa-miR-506-3p	86.3792	NM_022075
CERS2	hsa-miR-124-3p	86.3792	NM_022075
CERS2	hsa-miR-613	86.3661	NM_022075
CERS2	hsa-miR-206	86.3661	NM_022075
CERS2	hsa-miR-1-3p	86.3661	NM_022075
CERS2	hsa-miR-4775	86.0378	NM_022075
CERS2	hsa-miR-4441	85.9697	NM_022075
CERS2	hsa-miR-6852-5p	84.4864	NM_022075
CERS2	hsa-miR-2467-3p	84.0066	NM_022075
CERS2	hsa-miR-6776-5p	81.7697	NM_022075
CERS2	hsa-miR-7150	81.5378	NM_022075
CERS2	hsa-miR-6089	81.4594	NM_022075
CERS2	hsa-miR-6873-5p	81.3501	NM_022075
CERS2	hsa-miR-4716-5p	80.0194	NM_022075

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Motifs and transcription factors (TFs) regulating CERS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CERS2	transfac_pro__M07448	ZBED1 (directAnnotation).
CERS2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CERS2	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CERS2	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
CERS2	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
CERS2	metacluster_52.11	ZNF184 (directAnnotation).
CERS2	transfac_pro__M04826	EP300 (directAnnotation).
CERS2	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
CERS2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CERS2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CERS2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CERS2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CERS2	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
CERS2	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
CERS2	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).
CERS2	tfdimers__MD00299	ETS1; SRY (directAnnotation).
CERS2	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."