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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: CELSR2

Summary for CELSR2

Gene informationGene symbol

CELSR2

Ensembl ID

ENSG00000143126

Entrez ID

1952

Gene namecadherin EGF LAG seven-pass G-type receptor 2
SynonymsADGRC2|CDHF10|EGFL2|Flamingo1|KIAA0279|MEGF3
Gene typeprotein_coding
UniProtAcc

Q9HCU4


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Dataset with differentially expressed gene: CELSR2

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.4334860.00e+00

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Expression of CELSR2 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CELSR2

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CELSR2

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CELSR2hsa-miR-199a-3p99.1385NM_001408
CELSR2hsa-miR-3129-5p99.1385NM_001408
CELSR2hsa-miR-199b-3p99.1385NM_001408
CELSR2hsa-miR-222-5p97.8358NM_001408
CELSR2hsa-miR-92a-2-5p94.3818NM_001408
CELSR2hsa-miR-432-5p94.0251NM_001408
CELSR2hsa-miR-338-3p93.7443NM_001408
CELSR2hsa-miR-224-5p93.1747NM_001408
CELSR2hsa-miR-6783-3p92.2044NM_001408
CELSR2hsa-miR-5196-5p91.5119NM_001408
CELSR2hsa-miR-4747-5p91.5119NM_001408
CELSR2hsa-miR-6721-5p90.5223NM_001408
CELSR2hsa-miR-423-5p90.2874NM_001408
CELSR2hsa-miR-3184-5p90.2874NM_001408
CELSR2hsa-miR-345-3p90.2242NM_001408
CELSR2hsa-miR-806089.7612NM_001408
CELSR2hsa-miR-1343-3p89.7384NM_001408
CELSR2hsa-miR-1271-5p89.1871NM_001408
CELSR2hsa-miR-96-5p89.1871NM_001408
CELSR2hsa-miR-1213389.1871NM_001408
CELSR2hsa-miR-468388.3752NM_001408
CELSR2hsa-miR-6734-5p87.8765NM_001408
CELSR2hsa-miR-103a-3p87.8577NM_001408
CELSR2hsa-miR-10787.8577NM_001408
CELSR2hsa-miR-6889-5p86.7791NM_001408
CELSR2hsa-miR-317986.6368NM_001408
CELSR2hsa-miR-433086.5843NM_001408
CELSR2hsa-miR-6881-3p86.0838NM_001408
CELSR2hsa-miR-3675-5p86.0021NM_001408
CELSR2hsa-miR-6777-5p85.9976NM_001408
CELSR2hsa-miR-624-5p84.9366NM_001408
CELSR2hsa-miR-6825-5p84.7158NM_001408
CELSR2hsa-miR-519083.8277NM_001408
CELSR2hsa-miR-60882.0894NM_001408
CELSR2hsa-miR-465182.0894NM_001408
CELSR2hsa-miR-684481.7188NM_001408
CELSR2hsa-miR-3059-5p81.6545NM_001408
CELSR2hsa-miR-7110-3p81.368NM_001408
CELSR2hsa-miR-431-5p80.0051NM_001408
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Motifs and transcription factors (TFs) regulating CELSR2

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CELSR2transfac_pro__M04826EP300 (directAnnotation).
CELSR2taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_reprETV2; HES7 (directAnnotation).
CELSR2taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."