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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: CEBPG

Summary for CEBPG

Gene information	Gene symbol	CEBPG
	Ensembl ID	ENSG00000153879
	Entrez ID	1054
	Gene name	CCAAT enhancer binding protein gamma
	Synonyms	GPE1BP\|IG/EBP-1
	Gene type	protein_coding
	UniProtAcc	P53567

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Dataset with differentially expressed gene: CEBPG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.277017	1.82e-18
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.363162	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.459132	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.262184	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.266343	1.37e-08
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.294081	1.07e-06
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.342721	6.25e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.391632	2.79e-14
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.443192	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.35862	0.00e+00

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Expression of CEBPG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CEBPG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CEBPG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CEBPG	hsa-miR-4719	98.0208	NM_001806
CEBPG	hsa-miR-1200	94.1077	NM_001252296
CEBPG	hsa-miR-1275	92.7934	NM_001806
CEBPG	hsa-miR-369-3p	91.4594	NM_001806
CEBPG	hsa-miR-6839-3p	90.8685	NM_001806
CEBPG	hsa-miR-653-5p	88.4259	NM_001806
CEBPG	hsa-miR-4665-5p	86.5388	NM_001806
CEBPG	hsa-miR-12130	86.3028	NM_001806
CEBPG	hsa-miR-3163	85.7943	NM_001806
CEBPG	hsa-miR-516b-3p	85.6309	NM_001806
CEBPG	hsa-miR-516a-3p	85.6309	NM_001806
CEBPG	hsa-miR-7162-5p	85.6309	NM_001806
CEBPG	hsa-miR-4495	84.5663	NM_001806
CEBPG	hsa-miR-1228-3p	84.4853	NM_001252296
CEBPG	hsa-miR-3910	84.2909	NM_001252296
CEBPG	hsa-miR-3143	83.5622	NM_001806
CEBPG	hsa-miR-5010-3p	83.3034	NM_001806
CEBPG	hsa-miR-193a-5p	82.3768	NM_001806
CEBPG	hsa-miR-625-5p	82.1033	NM_001806
CEBPG	hsa-miR-1297	81.8333	NM_001252296
CEBPG	hsa-miR-582-3p	80.4946	NM_001806
CEBPG	hsa-miR-29a-5p	80.3597	NM_001252296
CEBPG	hsa-miR-153-5p	80.0501	NM_001806

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Motifs and transcription factors (TFs) regulating CEBPG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CEBPG	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CEBPG	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
CEBPG	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
CEBPG	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CEBPG	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
CEBPG	jaspar__MA1483.2	ELF2 (directAnnotation).
CEBPG	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CEBPG	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
CEBPG	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
CEBPG	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
CEBPG	jaspar__MA1957.1	ELK1 (directAnnotation).
CEBPG	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CEBPG	jaspar__MA0502.2	NFYB (directAnnotation).
CEBPG	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CEBPG	metacluster_7.13	ZFX (directAnnotation).
CEBPG	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CEBPG	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CEBPG	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CEBPG	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CEBPG	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CEBPG	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CEBPG	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CEBPG	metacluster_182.10	ZFX (directAnnotation).
CEBPG	cisbp__M00788	ZFY (inferredBy_Orthology).
CEBPG	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CEBPG	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CEBPG	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CEBPG	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CEBPG	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CEBPG	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CEBPG	transfac_pro__M01199	TRIM28 (directAnnotation).
CEBPG	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CEBPG	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CEBPG	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
CEBPG	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CEBPG	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
CEBPG	metacluster_156.2	up	Malignant cells	GSE139386	NA
CEBPG	metacluster_156.2	up	Malignant cells	GSE186960	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."