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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target

Gene: CEBPB

Summary for CEBPB

Gene information	Gene symbol	CEBPB
	Ensembl ID	ENSG00000172216
	Entrez ID	1051
	Gene name	CCAAT enhancer binding protein beta
	Synonyms	C/EBP-beta\|CRP2\|IL6DBP\|LAP\|NFIL6\|TCF5
	Gene type	protein_coding
	UniProtAcc	P17676

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Dataset with differentially expressed gene: CEBPB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.839599	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.408977	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.321589	6.78e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.412172	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.288825	1.04e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-1.03273	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.35357	1.73e-15
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.301161	1.94e-08
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.52412	2.55e-18
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	-0.364073	4.45e-15
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.341475	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	-0.259561	2.16e-30
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.296994	3.97e-02
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	0.303201	1.54e-05
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.475237	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Malignant cells	-0.256668	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.266894	2.32e-13
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.64455	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.434117	1.23e-04
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.291388	6.71e-07
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.523197	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	0.384834	8.52e-30
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.322553	0.00e+00

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Expression of CEBPB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CEBPB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CEBPB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CEBPB	hsa-miR-5011-5p	99.9181	NM_001285878
CEBPB	hsa-miR-369-3p	98.6628	NM_001285878
CEBPB	hsa-miR-190a-3p	98.3825	NM_001285878
CEBPB	hsa-miR-561-3p	98.151	NM_001285878
CEBPB	hsa-miR-374a-5p	97.8658	NM_001285878
CEBPB	hsa-miR-374b-5p	97.7221	NM_001285878
CEBPB	hsa-miR-5692b	97.3892	NM_001285878
CEBPB	hsa-miR-5692c	97.3892	NM_001285878
CEBPB	hsa-miR-374c-5p	97.3891	NM_001285878
CEBPB	hsa-miR-655-3p	97.3891	NM_001285878
CEBPB	hsa-miR-3613-3p	96.6625	NM_001285878
CEBPB	hsa-miR-373-5p	96.3248	NM_001285878
CEBPB	hsa-miR-616-5p	96.3248	NM_001285878
CEBPB	hsa-miR-371b-5p	96.3248	NM_001285878
CEBPB	hsa-miR-12136	92.8134	NM_001285878
CEBPB	hsa-miR-376a-3p	91.889	NM_001285878
CEBPB	hsa-miR-376b-3p	91.889	NM_001285878
CEBPB	hsa-miR-4520-2-3p	89.1568	NM_001285878
CEBPB	hsa-miR-155-5p	87.8262	NM_001285878
CEBPB	hsa-miR-627-3p	85.9749	NM_001285878

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Motifs and transcription factors (TFs) regulating CEBPB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CEBPB	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CEBPB	transfac_pro__M01175	ZBTB7B (directAnnotation).
CEBPB	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CEBPB	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
CEBPB	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
CEBPB	homer__NVCACGTG_NPAS	NPAS2 (inferredBy_Orthology).
CEBPB	cisbp__M05832	MAX (directAnnotation).
CEBPB	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
CEBPB	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CEBPB	hocomoco__MXI1_MOUSE.H11MO.1.A	MXI1 (inferredBy_Orthology).
CEBPB	taipale_cyt_meth__MLX_NCAYGTGN_eDBD_meth	MLX (directAnnotation).
CEBPB	tfdimers__MD00567	IKZF2 (directAnnotation).
CEBPB	dbtfbs__MLX_HepG2_ENCSR125DAD_merged_N1	MLX (directAnnotation).
CEBPB	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
CEBPB	metacluster_10.30	MXI1 (inferredBy_Orthology).
CEBPB	metacluster_10.46	MAX (inferredBy_Orthology).
CEBPB	transfac_pro__M02869	HOXA3 (inferredBy_Orthology).
CEBPB	taipale_tf_pairs__TEAD4_DLX2_RCATTCYNNNCAATTA_CAP	DLX2; TEAD4 (directAnnotation).
CEBPB	cisbp__M01815	CEBPE (inferredBy_Orthology).
CEBPB	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
CEBPB	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
CEBPB	metacluster_82.3	ZNF143 (directAnnotation). ZNF143 (inferredBy_Orthology).
CEBPB	metacluster_26.4	CDC5L; CDC5L; CDC5L; ZNF580; ZNF580 (directAnnotation).
CEBPB	tfdimers__MD00360	GATA3; PDX1 (directAnnotation).
CEBPB	taipale_tf_pairs__TEAD4_DLX3_RCATTCCNNNYAATTA_CAP	DLX3; TEAD4 (directAnnotation).
CEBPB	metacluster_32.19	ZNF354A (directAnnotation).
CEBPB	transfac_pro__M04855	IRF4 (directAnnotation).
CEBPB	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
CEBPB	hocomoco__HXD13_HUMAN.H11MO.0.D	HOXD13 (directAnnotation).
CEBPB	hocomoco__CPEB1_HUMAN.H11MO.0.D	CPEB1 (directAnnotation).
CEBPB	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
CEBPB	transfac_pro__M06086	ZNF17 (directAnnotation).
CEBPB	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CEBPB	tfdimers__MD00027	FOXG1; FOXO1; HLTF (directAnnotation).
CEBPB	transfac_pro__M06292	ZNF766 (directAnnotation).
CEBPB	transfac_pro__M07434	TRPS1 (directAnnotation).
CEBPB	metacluster_130.9	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
CEBPB	tfdimers__MD00255	PAX7; PITX3 (directAnnotation).
CEBPB	tfdimers__MD00370	YY1; ZNF384 (directAnnotation).
CEBPB	tfdimers__MD00281	CDX2; HNF4A; HNF4G; NR2F1; NR2F2 (directAnnotation).
CEBPB	metacluster_41.3	ZNF354A (directAnnotation).
CEBPB	tfdimers__MD00394	CDX2; PAX4 (directAnnotation).
CEBPB	jaspar__MA1108.2	MXI1 (directAnnotation).
CEBPB	metacluster_77.14	SOX7 (inferredBy_Orthology).
CEBPB	tfdimers__MD00124	HNF4A; HNF4G; NR2F1; NR2F2; PDX1 (directAnnotation).
CEBPB	tfdimers__MD00195	CDX2; FOXG1; FOXO1 (directAnnotation).
CEBPB	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CEBPB	metacluster_56.3	HSF2 (directAnnotation).
CEBPB	transfac_public__M00351	GATA3 (directAnnotation).
CEBPB	jaspar__MA1125.1	ZNF384 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
CEBPB	swissregulon__hs__CEBPB	down	Malignant cells	GSE161801_IMiD	post
CEBPB	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	down	Malignant cells	GSE161801_IMiD	post
CEBPB	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	up	Mono/Macro	GSE161801_IMiD	post
CEBPB	metacluster_46.4	up	Mono/Macro	GSE161801_IMiD	post
CEBPB	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	up	Mono/Macro	GSE161801_IMiD	post
CEBPB	homer__ATTGCGCAAC_CEBP	up	Mono/Macro	GSE161801_PI	post
CEBPB	metacluster_46.4	up	Mono/Macro	GSE161801_PI	post
CEBPB	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	up	Mono/Macro	GSE161801_PI	post
CEBPB	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNTTRCGYAAN_CAP	up	Mono/Macro	GSE161801_PI	post
CEBPB	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	down	Mono/Macro	GSE169246_PacBlood	post
CEBPB	tfdimers__MD00359	down	Mono/Macro	GSE169246_PacBlood	post
CEBPB	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	up	Mono/Macro	GSE197268_Tisa-cel	pre
CEBPB	homer__ATTGCGCAAC_CEBP	up	Mono/Macro	GSE197268_Tisa-cel	pre
CEBPB	metacluster_46.4	up	Mono/Macro	GSE197268_Tisa-cel	pre
CEBPB	tfdimers__MD00413	up	NK cells	GSE199333	pre
CEBPB	tfdimers__MD00232	up	NK cells	GSE199333	pre
CEBPB	metacluster_46.4	up	NK cells	GSE199333	pre
CEBPB	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNTTRCGYAAN_CAP	up	Neutrophils	GSE207422_Sin	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CEBPB	"Quercetin"	DB04216	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."