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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CEACAM6

Summary for CEACAM6

Gene information	Gene symbol	CEACAM6
	Ensembl ID	ENSG00000086548
	Entrez ID	4680
	Gene name	CEA cell adhesion molecule 6
	Synonyms	CD66c\|NCA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CEACAM6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.20469	1.59e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.31245	7.92e-38
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.958318	0.00e+00

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Expression of CEACAM6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CEACAM6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CEACAM6	Malignant cells	CPI-SS001BF66E8	CEACAM6_CEACAM6	CEACAM6	CEACAM6	False	Malignant cells	Malignant cells	GSE207422_Sin	post	resistant
CEACAM6	Malignant cells	CPI-SS001BF66E8	CEACAM6_CEACAM6	CEACAM6	CEACAM6	False	Malignant cells	Malignant cells	GSE207422_Sin	post	sensitive
CEACAM6	Malignant cells	CPI-SS001BF66E8	CEACAM6_CEACAM6	CEACAM6	CEACAM6	False	Malignant cells	Malignant cells	GSE207422_Tor	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CEACAM6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CEACAM6	hsa-miR-3119	95.5376	NM_002483
CEACAM6	hsa-miR-766-3p	91.2602	NM_002483
CEACAM6	hsa-miR-6720-5p	88.7453	NM_002483
CEACAM6	hsa-miR-6512-3p	88.7453	NM_002483
CEACAM6	hsa-miR-5702	86.965	NM_002483
CEACAM6	hsa-miR-1229-3p	85.8834	NM_002483
CEACAM6	hsa-miR-765	84.3805	NM_002483
CEACAM6	hsa-miR-4775	83.725	NM_002483
CEACAM6	hsa-miR-11181-3p	82.6349	NM_002483
CEACAM6	hsa-miR-3921	82.0084	NM_002483
CEACAM6	hsa-miR-4653-5p	82.0084	NM_002483
CEACAM6	hsa-miR-9-3p	81.842	NM_002483
CEACAM6	hsa-miR-5787	81.3393	NM_002483
CEACAM6	hsa-miR-4505	81.3393	NM_002483
CEACAM6	hsa-miR-338-3p	80.9996	NM_002483
CEACAM6	hsa-miR-183-3p	80.9868	NM_002483
CEACAM6	hsa-miR-140-3p	80.2313	NM_002483

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Motifs and transcription factors (TFs) regulating CEACAM6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CEACAM6	metacluster_22.13	MAFK (inferredBy_Orthology).
CEACAM6	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
CEACAM6	metacluster_22.32	NFE2L2 (directAnnotation).
CEACAM6	metacluster_22.19	NFE2 (directAnnotation).
CEACAM6	metacluster_22.17	NFE2 (directAnnotation).
CEACAM6	transfac_pro__M06408	ZSCAN30 (directAnnotation).
CEACAM6	transfac_pro__M06085	ZNF26 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."