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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDYL

Summary for CDYL

Gene information	Gene symbol	CDYL
	Ensembl ID	ENSG00000153046
	Entrez ID	9425
	Gene name	chromodomain Y like
	Synonyms	CDYL1\|DKFZP586C1622
	Gene type	protein_coding
	UniProtAcc	Q9Y232

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Dataset with differentially expressed gene: CDYL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.331688	2.61e-22
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.606066	2.17e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.286518	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.305534	0.00e+00

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Expression of CDYL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDYL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDYL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDYL	hsa-miR-101-3p	99.1528	NM_001143970
CDYL	hsa-miR-3163	98.9348	NM_001143970
CDYL	hsa-miR-181a-5p	97.6566	NM_001143970
CDYL	hsa-miR-181c-5p	97.6566	NM_001143970
CDYL	hsa-miR-181d-5p	97.6566	NM_001143970
CDYL	hsa-miR-181b-5p	97.6566	NM_001143970
CDYL	hsa-miR-548aj-3p	97.5119	NM_001143971
CDYL	hsa-miR-548x-3p	97.5119	NM_001143971
CDYL	hsa-miR-4262	97.379	NM_001143970
CDYL	hsa-miR-548aq-3p	96.7598	NM_001143971
CDYL	hsa-miR-548ah-3p	96.7598	NM_001143971
CDYL	hsa-miR-548ae-3p	96.7598	NM_001143971
CDYL	hsa-miR-548j-3p	96.7598	NM_001143971
CDYL	hsa-miR-548am-3p	96.7598	NM_001143971
CDYL	hsa-miR-144-3p	96.6062	NM_001143970
CDYL	hsa-let-7a-2-3p	96.4794	NM_001143970
CDYL	hsa-let-7g-3p	96.4794	NM_001143970
CDYL	hsa-miR-548g-3p	96.1731	NM_001143971
CDYL	hsa-miR-4724-5p	96.1017	NM_001143971
CDYL	hsa-miR-4703-3p	95.1145	NM_001143970
CDYL	hsa-miR-648	94.2312	NM_001143970
CDYL	hsa-miR-4803	94.0492	NM_001143970
CDYL	hsa-let-7c-3p	92.1627	NM_001143970
CDYL	hsa-miR-582-5p	91.2612	NM_001143970
CDYL	hsa-miR-200b-3p	91.1092	NM_001143970
CDYL	hsa-miR-429	91.1092	NM_001143970
CDYL	hsa-miR-200c-3p	91.1092	NM_001143970
CDYL	hsa-miR-7162-3p	90.8121	NM_001143970
CDYL	hsa-miR-101-5p	89.7194	NM_001143970
CDYL	hsa-miR-1323	88.6236	NM_001143971
CDYL	hsa-miR-432-5p	88.2772	NM_001143970
CDYL	hsa-miR-500b-3p	88.0995	NM_001143970
CDYL	hsa-miR-4276	87.7894	NM_001143970
CDYL	hsa-miR-548o-3p	87.5826	NM_001143971
CDYL	hsa-miR-5584-3p	87.0588	NM_001143970
CDYL	hsa-miR-4661-5p	86.5482	NM_001143970
CDYL	hsa-miR-190a-3p	85.8106	NM_001143971
CDYL	hsa-miR-485-3p	85.6474	NM_001143970
CDYL	hsa-miR-539-3p	85.6474	NM_001143970
CDYL	hsa-miR-555	85.6314	NM_001143970
CDYL	hsa-miR-12119	85.5038	NM_001143970
CDYL	hsa-miR-3658	84.3709	NM_001143971
CDYL	hsa-miR-4659b-3p	84.3259	NM_001143970
CDYL	hsa-miR-4659a-3p	84.3259	NM_001143970
CDYL	hsa-miR-570-3p	83.8436	NM_001143971
CDYL	hsa-miR-4531	83.8257	NM_001143970
CDYL	hsa-miR-6784-3p	83.8078	NM_001143970
CDYL	hsa-miR-548aw	83.6601	NM_001143971
CDYL	hsa-miR-5583-5p	82.8345	NM_001143971
CDYL	hsa-miR-3129-3p	82.8345	NM_001143971

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Motifs and transcription factors (TFs) regulating CDYL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDYL	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CDYL	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CDYL	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CDYL	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CDYL	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CDYL	transfac_pro__M04866	HDAC2 (directAnnotation).
CDYL	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CDYL	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CDYL	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
CDYL	jaspar__MA0502.2	NFYB (directAnnotation).
CDYL	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CDYL	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CDYL	transfac_pro__M04918	EGR1 (directAnnotation).
CDYL	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CDYL	metacluster_7.13	ZFX (directAnnotation).
CDYL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CDYL	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
CDYL	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CDYL	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDYL	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CDYL	cisbp__M00249	WT1 (directAnnotation).
CDYL	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CDYL	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CDYL	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CDYL	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CDYL	transfac_pro__M02089	E2F3 (directAnnotation).
CDYL	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDYL	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CDYL	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CDYL	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CDYL	hdpi__HIP2	UBE2K (directAnnotation).
CDYL	hdpi__NRL	NRL (directAnnotation).
CDYL	transfac_pro__M00430	E2F1 (directAnnotation).
CDYL	transfac_pro__M07329	SP7 (directAnnotation).
CDYL	transfac_pro__M07397	ZNF148 (directAnnotation).
CDYL	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CDYL	cisbp__M07938	E2F1 (directAnnotation).
CDYL	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CDYL	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CDYL	transfac_pro__M07436	WT1 (directAnnotation).
CDYL	metacluster_3.14	WT1; WT1 (directAnnotation).
CDYL	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CDYL	transfac_pro__M01837	KLF11 (directAnnotation).
CDYL	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CDYL	transfac_pro__M07310	SP5 (directAnnotation).
CDYL	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CDYL	transfac_pro__M04817	ZBTB33 (directAnnotation).
CDYL	swissregulon__hs__KLF6	KLF6 (directAnnotation).
CDYL	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
CDYL	transfac_pro__M00716	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."