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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDS2

Summary for CDS2

Gene information	Gene symbol	CDS2
	Ensembl ID	ENSG00000101290
	Entrez ID	8760
	Gene name	CDP-diacylglycerol synthase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O95674

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Dataset with differentially expressed gene: CDS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.333604	0.00e+00

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Expression of CDS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CDS2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CDS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDS2	hsa-miR-6752-3p	93.622	NM_003818
CDS2	hsa-miR-6821-5p	89.9561	NM_003818
CDS2	hsa-miR-10394-5p	89.3578	NM_003818
CDS2	hsa-miR-4471	87.4456	NM_003818
CDS2	hsa-miR-4291	87.2492	NM_003818
CDS2	hsa-miR-570-3p	86.8202	NM_003818
CDS2	hsa-miR-3160-5p	86.7853	NM_003818
CDS2	hsa-miR-646	86.5986	NM_003818
CDS2	hsa-miR-8059	86.189	NM_003818
CDS2	hsa-miR-1205	85.3801	NM_003818
CDS2	hsa-miR-5692a	85.123	NM_003818
CDS2	hsa-miR-1277-5p	84.5836	NM_003818
CDS2	hsa-miR-4319	84.5228	NM_003818
CDS2	hsa-miR-548t-3p	84.4701	NM_003818
CDS2	hsa-miR-548ap-3p	84.4701	NM_003818
CDS2	hsa-miR-548aa	84.4701	NM_003818
CDS2	hsa-miR-3613-3p	84.3811	NM_003818
CDS2	hsa-miR-4719	83.4161	NM_003818
CDS2	hsa-miR-548d-3p	82.5764	NM_003818
CDS2	hsa-miR-548ac	82.5764	NM_003818
CDS2	hsa-miR-548z	82.5764	NM_003818
CDS2	hsa-miR-548h-3p	82.5764	NM_003818
CDS2	hsa-miR-548bb-3p	82.5764	NM_003818
CDS2	hsa-miR-4307	82.5128	NM_003818
CDS2	hsa-miR-4303	82.2097	NM_003818
CDS2	hsa-miR-8060	82.0883	NM_003818
CDS2	hsa-miR-23c	80.9753	NM_003818
CDS2	hsa-miR-23a-3p	80.9753	NM_003818
CDS2	hsa-miR-23b-3p	80.9753	NM_003818
CDS2	hsa-miR-345-3p	80.7327	NM_003818
CDS2	hsa-miR-450a-1-3p	80.0082	NM_003818

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Motifs and transcription factors (TFs) regulating CDS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDS2	metacluster_7.13	ZFX (directAnnotation).
CDS2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CDS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CDS2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CDS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CDS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."