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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDKN2AIP

Summary for CDKN2AIP

Gene information	Gene symbol	CDKN2AIP
	Ensembl ID	ENSG00000168564
	Entrez ID	55602
	Gene name	CDKN2A interacting protein
	Synonyms	CARF\|FLJ20036
	Gene type	protein_coding
	UniProtAcc	Q9NXV6

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Dataset with differentially expressed gene: CDKN2AIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.26251	0.00e+00

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Expression of CDKN2AIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDKN2AIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDKN2AIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDKN2AIP	hsa-miR-12135	95.3523	NM_017632
CDKN2AIP	hsa-miR-3671	95.08	NM_017632
CDKN2AIP	hsa-miR-144-3p	94.4327	NM_017632
CDKN2AIP	hsa-miR-146a-3p	94.2795	NM_001317343
CDKN2AIP	hsa-miR-4261	93.3346	NM_001317343
CDKN2AIP	hsa-miR-656-3p	93.1798	NM_017632
CDKN2AIP	hsa-miR-380-3p	92.9424	NM_001317343
CDKN2AIP	hsa-miR-526b-5p	92.5927	NM_001317343
CDKN2AIP	hsa-miR-545-3p	91.8616	NM_001317343
CDKN2AIP	hsa-miR-6868-3p	91.8236	NM_001317343
CDKN2AIP	hsa-miR-153-5p	91.2381	NM_017632
CDKN2AIP	hsa-miR-6809-3p	90.9567	NM_017632
CDKN2AIP	hsa-miR-548e-5p	90.697	NM_017632
CDKN2AIP	hsa-miR-3658	89.997	NM_017632
CDKN2AIP	hsa-miR-4422	89.6954	NM_017632
CDKN2AIP	hsa-miR-6079	89.1961	NM_001317343
CDKN2AIP	hsa-miR-675-3p	88.8927	NM_017632
CDKN2AIP	hsa-miR-147b-5p	88.7225	NM_001317343
CDKN2AIP	hsa-miR-9903	88.2278	NM_017632
CDKN2AIP	hsa-miR-4262	87.8042	NM_017632
CDKN2AIP	hsa-miR-6873-3p	87.6954	NM_017632
CDKN2AIP	hsa-miR-889-3p	86.6087	NM_017632
CDKN2AIP	hsa-miR-6842-3p	86.4167	NM_001317343
CDKN2AIP	hsa-miR-7-5p	86.2851	NM_001317343
CDKN2AIP	hsa-miR-3605-5p	86.2536	NM_001317343
CDKN2AIP	hsa-miR-875-3p	86.1761	NM_017632
CDKN2AIP	hsa-miR-4709-3p	85.8735	NM_001317343
CDKN2AIP	hsa-miR-6515-3p	85.4496	NM_017632
CDKN2AIP	hsa-miR-375-3p	85.179	NM_017632
CDKN2AIP	hsa-miR-3121-3p	84.9879	NM_001317343
CDKN2AIP	hsa-miR-1537-5p	84.4057	NM_017632
CDKN2AIP	hsa-miR-544a	84.1976	NM_001317343
CDKN2AIP	hsa-miR-1227-5p	84.1517	NM_017632
CDKN2AIP	hsa-miR-7153-5p	84.0428	NM_001317343
CDKN2AIP	hsa-miR-6833-3p	82.9337	NM_017632
CDKN2AIP	hsa-miR-15b-3p	82.3151	NM_017632
CDKN2AIP	hsa-miR-6083	82.0658	NM_017632
CDKN2AIP	hsa-miR-3148	81.8356	NM_017632
CDKN2AIP	hsa-miR-558	81.6363	NM_001317343
CDKN2AIP	hsa-miR-593-3p	81.6301	NM_001317343
CDKN2AIP	hsa-miR-6884-3p	81.0945	NM_001317343
CDKN2AIP	hsa-miR-503-5p	80.9207	NM_001317343
CDKN2AIP	hsa-miR-6500-3p	80.321	NM_001317343
CDKN2AIP	hsa-miR-550a-3-5p	80.277	NM_001317343
CDKN2AIP	hsa-miR-550a-5p	80.277	NM_001317343
CDKN2AIP	hsa-miR-1271-3p	80.277	NM_001317343
CDKN2AIP	hsa-miR-154-5p	80.2256	NM_017632

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Motifs and transcription factors (TFs) regulating CDKN2AIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDKN2AIP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDKN2AIP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDKN2AIP	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CDKN2AIP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDKN2AIP	metacluster_7.13	ZFX (directAnnotation).
CDKN2AIP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CDKN2AIP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CDKN2AIP	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CDKN2AIP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CDKN2AIP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CDKN2AIP	transfac_pro__M02089	E2F3 (directAnnotation).
CDKN2AIP	metacluster_3.14	WT1; WT1 (directAnnotation).
CDKN2AIP	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CDKN2AIP	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CDKN2AIP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CDKN2AIP	cisbp__M07938	E2F1 (directAnnotation).
CDKN2AIP	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CDKN2AIP	transfac_pro__M07436	WT1 (directAnnotation).
CDKN2AIP	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CDKN2AIP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CDKN2AIP	transfac_pro__M02898	SMAD3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."