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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDKN1B

Summary for CDKN1B

Gene information	Gene symbol	CDKN1B
	Ensembl ID	ENSG00000111276
	Entrez ID	1027
	Gene name	cyclin dependent kinase inhibitor 1B
	Synonyms	KIP1\|P27KIP1
	Gene type	protein_coding
	UniProtAcc	P46527

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Dataset with differentially expressed gene: CDKN1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.303945	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.275484	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.396644	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.419267	1.19e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.337382	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.342129	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.272756	2.71e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.71692	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.558878	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.273776	0.00e+00

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Expression of CDKN1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDKN1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CDKN1B	Regulation by the Disease Microenvironment
CDKN1B	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CDKN1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDKN1B	hsa-miR-6768-5p	99.9152	NM_004064
CDKN1B	hsa-miR-222-3p	99.2797	NM_004064
CDKN1B	hsa-miR-221-3p	99.2797	NM_004064
CDKN1B	hsa-miR-4672	99.0659	NM_004064
CDKN1B	hsa-miR-4276	98.7756	NM_004064
CDKN1B	hsa-miR-4803	97.29	NM_004064
CDKN1B	hsa-miR-30a-3p	96.5868	NM_004064
CDKN1B	hsa-miR-30e-3p	96.5868	NM_004064
CDKN1B	hsa-miR-30d-3p	96.5868	NM_004064
CDKN1B	hsa-miR-3977	96.076	NM_004064
CDKN1B	hsa-miR-1827	95.9904	NM_004064
CDKN1B	hsa-miR-4255	95.1795	NM_004064
CDKN1B	hsa-miR-6866-5p	94.9425	NM_004064
CDKN1B	hsa-miR-187-5p	94.8687	NM_004064
CDKN1B	hsa-miR-548v	94.8687	NM_004064
CDKN1B	hsa-miR-4789-5p	94.0661	NM_004064
CDKN1B	hsa-miR-455-5p	93.3223	NM_004064
CDKN1B	hsa-miR-302c-5p	93.1772	NM_004064
CDKN1B	hsa-miR-122b-5p	93.1285	NM_004064
CDKN1B	hsa-miR-150-5p	92.5978	NM_004064
CDKN1B	hsa-miR-10527-5p	92.296	NM_004064
CDKN1B	hsa-miR-148a-3p	91.9175	NM_004064
CDKN1B	hsa-miR-3924	91.149	NM_004064
CDKN1B	hsa-miR-452-5p	90.9979	NM_004064
CDKN1B	hsa-miR-4676-3p	90.9979	NM_004064
CDKN1B	hsa-miR-892c-3p	90.9979	NM_004064
CDKN1B	hsa-miR-141-5p	90.5527	NM_004064
CDKN1B	hsa-miR-502-5p	90.2502	NM_004064
CDKN1B	hsa-miR-153-5p	90.248	NM_004064
CDKN1B	hsa-miR-4282	90.2268	NM_004064
CDKN1B	hsa-miR-335-3p	90.1944	NM_004064
CDKN1B	hsa-miR-4713-5p	90.0078	NM_004064
CDKN1B	hsa-miR-4797-5p	89.7804	NM_004064
CDKN1B	hsa-miR-152-3p	89.4678	NM_004064
CDKN1B	hsa-miR-148b-3p	89.4678	NM_004064
CDKN1B	hsa-miR-4496	88.704	NM_004064
CDKN1B	hsa-miR-190b-5p	88.4696	NM_004064
CDKN1B	hsa-miR-190a-5p	88.4696	NM_004064
CDKN1B	hsa-miR-520f-3p	88.1738	NM_004064
CDKN1B	hsa-miR-548aj-3p	87.9888	NM_004064
CDKN1B	hsa-miR-548x-3p	87.9888	NM_004064
CDKN1B	hsa-miR-323a-3p	87.5161	NM_004064
CDKN1B	hsa-miR-6830-5p	86.8139	NM_004064
CDKN1B	hsa-miR-548aq-3p	86.6757	NM_004064
CDKN1B	hsa-miR-548ah-3p	86.6757	NM_004064
CDKN1B	hsa-miR-548j-3p	86.6757	NM_004064
CDKN1B	hsa-miR-548ae-3p	86.6757	NM_004064
CDKN1B	hsa-miR-548am-3p	86.6757	NM_004064
CDKN1B	hsa-miR-3140-3p	86.6017	NM_004064
CDKN1B	hsa-miR-24-3p	86.3708	NM_004064

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Motifs and transcription factors (TFs) regulating CDKN1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDKN1B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDKN1B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDKN1B	transfac_pro__M07397	ZNF148 (directAnnotation).
CDKN1B	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CDKN1B	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CDKN1B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDKN1B	metacluster_7.13	ZFX (directAnnotation).
CDKN1B	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CDKN1B	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CDKN1B	transfac_pro__M01175	ZBTB7B (directAnnotation).
CDKN1B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CDKN1B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CDKN1B	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CDKN1B	transfac_pro__M01303	SP1 (directAnnotation).
CDKN1B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CDKN1B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CDKN1B	transfac_pro__M01714	KLF15 (directAnnotation).
CDKN1B	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CDKN1B	transfac_pro__M02089	E2F3 (directAnnotation).
CDKN1B	metacluster_3.14	WT1; WT1 (directAnnotation).
CDKN1B	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CDKN1B	cisbp__M07938	E2F1 (directAnnotation).
CDKN1B	transfac_pro__M07436	WT1 (directAnnotation).
CDKN1B	transfac_pro__M02281	SP1 (directAnnotation).
CDKN1B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CDKN1B	transfac_pro__M02898	SMAD3 (directAnnotation).
CDKN1B	transfac_public__M00491	PATZ1 (directAnnotation).
CDKN1B	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CDKN1B	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CDKN1B	transfac_pro__M01783	SP2 (directAnnotation).
CDKN1B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CDKN1B	transfac_pro__M01253	CNOT3 (directAnnotation).
CDKN1B	cisbp__M00968	MTF2 (directAnnotation).
CDKN1B	transfac_pro__M04817	ZBTB33 (directAnnotation).
CDKN1B	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CDKN1B	jaspar__MA0748.2	YY2 (directAnnotation).
CDKN1B	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CDKN1B	hdpi__NRL	NRL (directAnnotation).
CDKN1B	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CDKN1B	hdpi__FEZF2	FEZF2 (directAnnotation).
CDKN1B	transfac_pro__M07310	SP5 (directAnnotation).
CDKN1B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CDKN1B	hdpi__HIP2	UBE2K (directAnnotation).
CDKN1B	hdpi__ZNF304	ZNF304 (directAnnotation).
CDKN1B	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
CDKN1B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CDKN1B	tfdimers__MD00483	ZBTB14 (directAnnotation).
CDKN1B	transfac_pro__M07317	CTBP1 (directAnnotation).
CDKN1B	transfac_pro__M12697	ZNF142 (directAnnotation).
CDKN1B	transfac_pro__M00716	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."