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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDK2AP2

Summary for CDK2AP2

Gene information	Gene symbol	CDK2AP2
	Ensembl ID	ENSG00000167797
	Entrez ID	10263
	Gene name	cyclin dependent kinase 2 associated protein 2
	Synonyms	DOC-1R\|p14
	Gene type	protein_coding
	UniProtAcc	O75956

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Dataset with differentially expressed gene: CDK2AP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.36065	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.270815	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	-0.311511	6.71e-04
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.414409	1.57e-36
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.276229	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.33468	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.333577	3.26e-32
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.336318	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.499991	7.36e-26
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.753623	8.71e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.752941	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.485779	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.4745	4.95e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.287631	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.312492	1.65e-21
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.305405	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.258339	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.356516	0.00e+00

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Expression of CDK2AP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDK2AP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDK2AP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDK2AP2	hsa-miR-4516	82.2549	NM_001271849
CDK2AP2	hsa-miR-4761-3p	81.7434	NM_001271849
CDK2AP2	hsa-miR-4441	80.5155	NM_001271849

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Motifs and transcription factors (TFs) regulating CDK2AP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDK2AP2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CDK2AP2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CDK2AP2	transfac_pro__M04748	GABPA (directAnnotation).
CDK2AP2	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CDK2AP2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CDK2AP2	swissregulon__hs__SPI1	SPI1 (directAnnotation).
CDK2AP2	tfdimers__MD00561	CRX (directAnnotation).
CDK2AP2	transfac_pro__M01251	E2F1 (directAnnotation).
CDK2AP2	taipale_tf_pairs__ELK1_EVX1_RSCGGWANNNNYMATTA_CAP_repr	ELK1; EVX1 (directAnnotation).
CDK2AP2	cisbp__M01815	CEBPE (inferredBy_Orthology).
CDK2AP2	transfac_pro__M06832	PEG3 (directAnnotation).
CDK2AP2	tfdimers__MD00367	CDX2; IKZF1 (directAnnotation).
CDK2AP2	transfac_pro__M07285	ELF3 (directAnnotation).
CDK2AP2	metacluster_183.3	EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
CDK2AP2	metacluster_9.47	PAX7 (inferredBy_Orthology).
CDK2AP2	transfac_pro__M05990	ZNF69 (directAnnotation).
CDK2AP2	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
CDK2AP2	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CDK2AP2	transfac_pro__M05708	ZNF136 (directAnnotation).
CDK2AP2	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
CDK2AP2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CDK2AP2	metacluster_79.18	ZNF81; ZNF81 (directAnnotation).
CDK2AP2	jaspar__MA1509.1	IRF6 (directAnnotation).
CDK2AP2	transfac_pro__M07385	LHX2 (directAnnotation).
CDK2AP2	taipale_tf_pairs__POU2F1_FOXO6_RMATATKCNNNNNNNNNNNNNRWMAACA_CAP_repr	FOXO6; POU2F1 (directAnnotation).
CDK2AP2	tfdimers__MD00078	HOXD1; TCF7L1 (directAnnotation).
CDK2AP2	transfac_pro__M02869	HOXA3 (inferredBy_Orthology).
CDK2AP2	transfac_pro__M01275	PDX1 (directAnnotation).
CDK2AP2	jaspar__MA1498.2	HOXA7 (directAnnotation).
CDK2AP2	hocomoco__HME2_HUMAN.H11MO.0.D	EN2 (directAnnotation).
CDK2AP2	transfac_public__M00137	POU2F1 (directAnnotation).
CDK2AP2	transfac_pro__M06952	BATF (directAnnotation).
CDK2AP2	metacluster_161.63	HOXB8 (directAnnotation).
CDK2AP2	transfac_pro__M02903	SOX15 (inferredBy_Orthology).
CDK2AP2	transfac_pro__M04616	ISL1 (directAnnotation). LHX3 (inferredBy_Orthology).
CDK2AP2	metacluster_130.18	FOXD2; FOXD2 (directAnnotation). FOXA2; FOXD2; FOXD2 (inferredBy_Orthology).
CDK2AP2	taipale_tf_pairs__HOXD4_NNYMATTANN_HT	HOXD4 (directAnnotation).
CDK2AP2	transfac_pro__M05838	ZNF550 (directAnnotation).
CDK2AP2	metacluster_161.13	ISX (directAnnotation).
CDK2AP2	transfac_pro__M06659	ZSCAN10 (directAnnotation).
CDK2AP2	tfdimers__MD00274	MYCN (directAnnotation).
CDK2AP2	transfac_pro__M03847	SOX15 (directAnnotation).
CDK2AP2	tfdimers__MD00140	IRF1; OTX1; OTX2 (directAnnotation).
CDK2AP2	taipale_tf_pairs__HOXB2_ELF1_NNYMATTANNNNNNNGGAAGNN_CAP_repr	ELF1; HOXB2 (directAnnotation).
CDK2AP2	taipale_tf_pairs__GCM2_TBX21_NNNCGGGNNNGGTGTNN_CAP_repr	GCM2; TBX21 (directAnnotation).
CDK2AP2	tfdimers__MD00517	POU5F1 (directAnnotation).
CDK2AP2	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
CDK2AP2	taipale_cyt_meth__TLX3_NAATTGNNNNNNNNNNCAATTN_FL_repr	TLX3 (directAnnotation).
CDK2AP2	transfac_pro__M06806	PEG3 (directAnnotation).
CDK2AP2	transfac_pro__M04906	SIN3A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."