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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CDK16

Summary for CDK16

Gene information	Gene symbol	CDK16
	Ensembl ID	ENSG00000102225
	Entrez ID	5127
	Gene name	cyclin dependent kinase 16
	Synonyms	FLJ16665\|PCTAIRE\|PCTAIRE1\|PCTGAIRE\|PCTK1
	Gene type	protein_coding
	UniProtAcc	Q00536

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Dataset with differentially expressed gene: CDK16

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.393248	1.14e-33
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.491659	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.444426	1.52e-23
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.343796	2.09e-18

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Expression of CDK16 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDK16

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDK16

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDK16	hsa-miR-92b-3p	98.3619	NM_033018
CDK16	hsa-miR-92a-3p	98.3619	NM_033018
CDK16	hsa-miR-32-5p	98.3619	NM_033018
CDK16	hsa-miR-367-3p	98.0535	NM_033018
CDK16	hsa-miR-363-3p	98.0535	NM_033018
CDK16	hsa-miR-1972	97.4787	NM_006201
CDK16	hsa-miR-25-3p	97.4745	NM_033018
CDK16	hsa-miR-6510-5p	95.1005	NM_006201
CDK16	hsa-miR-4692	94.9815	NM_006201
CDK16	hsa-miR-4514	94.5461	NM_006201
CDK16	hsa-miR-6721-5p	93.9604	NM_006201
CDK16	hsa-miR-33b-5p	91.9212	NM_033018
CDK16	hsa-miR-33a-5p	91.9212	NM_033018
CDK16	hsa-miR-6722-3p	91.8568	NM_006201
CDK16	hsa-miR-1912-5p	91.6308	NM_033018
CDK16	hsa-miR-940	90.7255	NM_006201
CDK16	hsa-miR-6893-5p	89.5145	NM_006201
CDK16	hsa-miR-6808-5p	89.5145	NM_006201
CDK16	hsa-miR-1909-3p	89.052	NM_006201
CDK16	hsa-miR-3199	88.9301	NM_006201
CDK16	hsa-miR-7702	88.6122	NM_006201
CDK16	hsa-miR-24-3p	87.9271	NM_006201
CDK16	hsa-miR-6846-5p	87.2003	NM_006201
CDK16	hsa-miR-6848-5p	87.2003	NM_006201
CDK16	hsa-miR-485-3p	83.3251	NM_033018
CDK16	hsa-miR-539-3p	83.3251	NM_033018
CDK16	hsa-miR-593-3p	82.9452	NM_006201
CDK16	hsa-miR-504-5p	82.2288	NM_033018
CDK16	hsa-miR-4725-5p	82.2288	NM_033018
CDK16	hsa-miR-4690-5p	81.9419	NM_006201
CDK16	hsa-miR-4736	81.0652	NM_006201
CDK16	hsa-miR-4317	81.0095	NM_033018

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Motifs and transcription factors (TFs) regulating CDK16

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDK16	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CDK16	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CDK16	jaspar__MA0502.2	NFYB (directAnnotation).
CDK16	cisbp__M00249	WT1 (directAnnotation).
CDK16	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
CDK16	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CDK16	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
CDK16	hdpi__TP73	TP73 (directAnnotation).
CDK16	metacluster_183.4	ETS1 (inferredBy_Orthology).
CDK16	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CDK16	metacluster_81.7	CREB1 (directAnnotation).
CDK16	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CDK16	"(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}"	DB07766	small molecule
CDK16	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."