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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDH2

Summary for CDH2

Gene information	Gene symbol	CDH2
	Ensembl ID	ENSG00000170558
	Entrez ID	1000
	Gene name	cadherin 2
	Synonyms	CD325\|CDHN\|NCAD
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CDH2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.447791	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.705295	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.275249	2.03e-12

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Expression of CDH2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDH2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDH2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDH2	hsa-miR-150-3p	98.0819	NM_001308176
CDH2	hsa-miR-1283	96.9955	NM_001308176
CDH2	hsa-miR-548e-5p	96.9096	NM_001308176
CDH2	hsa-miR-8068	96.0891	NM_001308176
CDH2	hsa-miR-187-5p	95.4647	NM_001308176
CDH2	hsa-miR-3606-5p	93.9552	NM_001308176
CDH2	hsa-miR-8077	93.8898	NM_001308176
CDH2	hsa-miR-493-5p	93.2702	NM_001308176
CDH2	hsa-miR-543	93.0298	NM_001308176
CDH2	hsa-miR-222-3p	91.5	NM_001308176
CDH2	hsa-miR-221-3p	91.5	NM_001308176
CDH2	hsa-miR-548v	91.5	NM_001308176
CDH2	hsa-miR-4795-5p	90.4752	NM_001308176
CDH2	hsa-miR-450a-1-3p	90.4664	NM_001308176
CDH2	hsa-miR-5089-3p	90.3773	NM_001308176
CDH2	hsa-miR-9-3p	90.1492	NM_001308176
CDH2	hsa-miR-921	89.394	NM_001308176
CDH2	hsa-miR-3670	89.1888	NM_001308176
CDH2	hsa-miR-124-3p	89.1491	NM_001308176
CDH2	hsa-miR-506-3p	89.1491	NM_001308176
CDH2	hsa-miR-4802-3p	88.3318	NM_001308176
CDH2	hsa-miR-122b-5p	88.2476	NM_001308176
CDH2	hsa-miR-4643	88.0114	NM_001308176
CDH2	hsa-miR-3148	85.3094	NM_001308176
CDH2	hsa-miR-411-5p	84.9639	NM_001308176
CDH2	hsa-miR-548aw	84.8955	NM_001308176
CDH2	hsa-miR-1263	84.812	NM_001308176
CDH2	hsa-miR-217-3p	84.6161	NM_001308176
CDH2	hsa-miR-7844-5p	83.8648	NM_001308176
CDH2	hsa-miR-7156-3p	83.4951	NM_001308176
CDH2	hsa-miR-6729-3p	83.3008	NM_001308176
CDH2	hsa-miR-3924	83.204	NM_001308176
CDH2	hsa-miR-6513-3p	83.1668	NM_001308176
CDH2	hsa-miR-3177-5p	83.1642	NM_001308176
CDH2	hsa-miR-4775	83.0985	NM_001308176
CDH2	hsa-miR-548an	82.9921	NM_001308176
CDH2	hsa-miR-3143	82.5487	NM_001308176
CDH2	hsa-miR-3925-3p	82.469	NM_001308176
CDH2	hsa-miR-320d	81.5946	NM_001308176
CDH2	hsa-miR-320a-3p	81.5946	NM_001308176
CDH2	hsa-miR-320c	81.5946	NM_001308176
CDH2	hsa-miR-320b	81.5946	NM_001308176
CDH2	hsa-miR-4429	81.5946	NM_001308176
CDH2	hsa-miR-2113	81.4706	NM_001308176
CDH2	hsa-miR-4774-5p	81.269	NM_001308176
CDH2	hsa-miR-4490	81.269	NM_001308176
CDH2	hsa-miR-4668-3p	81.2163	NM_001308176
CDH2	hsa-miR-7853-5p	80.2475	NM_001308176
CDH2	hsa-miR-105-5p	80.2475	NM_001308176
CDH2	hsa-miR-6507-3p	80.2089	NM_001308176

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Motifs and transcription factors (TFs) regulating CDH2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDH2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDH2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDH2	transfac_pro__M07397	ZNF148 (directAnnotation).
CDH2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CDH2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CDH2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CDH2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDH2	metacluster_7.13	ZFX (directAnnotation).
CDH2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CDH2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CDH2	transfac_pro__M01175	ZBTB7B (directAnnotation).
CDH2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CDH2	tfdimers__MD00151	CHURC1 (directAnnotation).
CDH2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CDH2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CDH2	transfac_pro__M01303	SP1 (directAnnotation).
CDH2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CDH2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CDH2	transfac_pro__M02090	E2F4 (directAnnotation).
CDH2	transfac_pro__M01714	KLF15 (directAnnotation).
CDH2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CDH2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CDH2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CDH2	transfac_pro__M02089	E2F3 (directAnnotation).
CDH2	transfac_pro__M12604	ZNF444 (directAnnotation).
CDH2	metacluster_3.14	WT1; WT1 (directAnnotation).
CDH2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CDH2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CDH2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CDH2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CDH2	cisbp__M07938	E2F1 (directAnnotation).
CDH2	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
CDH2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CDH2	transfac_pro__M07436	WT1 (directAnnotation).
CDH2	transfac_pro__M02281	SP1 (directAnnotation).
CDH2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CDH2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CDH2	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
CDH2	transfac_pro__M02898	SMAD3 (directAnnotation).
CDH2	transfac_public__M00491	PATZ1 (directAnnotation).
CDH2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CDH2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
CDH2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CDH2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CDH2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CDH2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CDH2	transfac_pro__M04826	EP300 (directAnnotation).
CDH2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CDH2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CDH2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."