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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDH13

Summary for CDH13

Gene information	Gene symbol	CDH13
	Ensembl ID	ENSG00000140945
	Entrez ID	1012
	Gene name	cadherin 13
	Synonyms	CDHH
	Gene type	protein_coding
	UniProtAcc	P55290

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Dataset with differentially expressed gene: CDH13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.350855	0.00e+00

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Expression of CDH13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDH13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDH13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDH13	hsa-miR-660-5p	95.8718	NM_001220488
CDH13	hsa-miR-6867-5p	95.5713	NM_001220490
CDH13	hsa-miR-6876-3p	95.5072	NM_001220488
CDH13	hsa-miR-626	95.5072	NM_001220488
CDH13	hsa-miR-4641	95.3317	NM_001220490
CDH13	hsa-miR-20a-3p	93.9708	NM_001220490
CDH13	hsa-miR-5008-5p	92.6	NM_001220488
CDH13	hsa-miR-6765-5p	91.6022	NM_001220488
CDH13	hsa-miR-1178-3p	90.8883	NM_001220488
CDH13	hsa-miR-3611	90.0816	NM_001220490
CDH13	hsa-miR-539-3p	90.0025	NM_001220488
CDH13	hsa-miR-485-3p	90.0025	NM_001220488
CDH13	hsa-miR-6514-3p	89.7868	NM_001220490
CDH13	hsa-miR-3688-3p	89.1732	NM_001220490
CDH13	hsa-miR-377-3p	88.9956	NM_001220490
CDH13	hsa-miR-6089	88.3107	NM_001220488
CDH13	hsa-miR-34a-5p	87.8297	NM_001220488
CDH13	hsa-miR-449a	87.8297	NM_001220488
CDH13	hsa-miR-302f	87.4572	NM_001220492
CDH13	hsa-miR-4698	87.3823	NM_001220490
CDH13	hsa-miR-548at-3p	87.3489	NM_001220488
CDH13	hsa-miR-5003-3p	87.1051	NM_001220490
CDH13	hsa-miR-12128	87.1025	NM_001220490
CDH13	hsa-miR-5011-3p	87.0244	NM_001220492
CDH13	hsa-miR-367-5p	86.7052	NM_001220488
CDH13	hsa-miR-3942-3p	86.41	NM_001220488
CDH13	hsa-miR-493-5p	86.3546	NM_001220490
CDH13	hsa-miR-31-3p	86.2689	NM_001220488
CDH13	hsa-miR-548au-3p	85.7085	NM_001220488
CDH13	hsa-miR-548ay-3p	85.1634	NM_001220488
CDH13	hsa-miR-6853-3p	84.741	NM_001220492
CDH13	hsa-miR-34c-5p	84.5834	NM_001220488
CDH13	hsa-miR-449b-5p	84.5834	NM_001220488
CDH13	hsa-miR-224-5p	82.9373	NM_001220490
CDH13	hsa-miR-1304-5p	81.935	NM_001220488
CDH13	hsa-miR-4633-5p	81.3043	NM_001220490
CDH13	hsa-miR-1266-3p	81.2013	NM_001220488
CDH13	hsa-miR-6499-3p	80.6702	NM_001220488

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Motifs and transcription factors (TFs) regulating CDH13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDH13	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
CDH13	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
CDH13	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
CDH13	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CDH13	transfac_public__M00041	ATF2; JUN (directAnnotation).
CDH13	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."