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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CDH11

Summary for CDH11

Gene information	Gene symbol	CDH11
	Ensembl ID	ENSG00000140937
	Entrez ID	1009
	Gene name	cadherin 11
	Synonyms	CAD11\|OB
	Gene type	protein_coding
	UniProtAcc	P55287

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Dataset with differentially expressed gene: CDH11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	4.49763	6.71e-08

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Expression of CDH11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDH11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDH11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDH11	hsa-miR-493-5p	99.5631	NM_001797
CDH11	hsa-miR-548p	99.2596	NM_001308392
CDH11	hsa-let-7c-3p	98.9712	NM_001797
CDH11	hsa-miR-10527-5p	98.7327	NM_001308392
CDH11	hsa-miR-3163	98.6285	NM_001797
CDH11	hsa-miR-103a-2-5p	98.5214	NM_001797
CDH11	hsa-miR-3145-3p	98.4613	NM_001797
CDH11	hsa-miR-103a-1-5p	98.3606	NM_001797
CDH11	hsa-miR-1468-3p	97.4251	NM_001308392
CDH11	hsa-miR-4511	97.0395	NM_001797
CDH11	hsa-miR-6806-3p	96.9986	NM_001797
CDH11	hsa-miR-3928-5p	96.9986	NM_001797
CDH11	hsa-miR-1206	96.9746	NM_001797
CDH11	hsa-miR-205-5p	96.383	NM_001308392
CDH11	hsa-miR-3149	95.2409	NM_001308392
CDH11	hsa-miR-1248	94.8317	NM_001797
CDH11	hsa-miR-548m	94.337	NM_001308392
CDH11	hsa-miR-6853-3p	94.2541	NM_001797
CDH11	hsa-let-7g-3p	94.1245	NM_001308392
CDH11	hsa-let-7a-2-3p	94.1245	NM_001308392
CDH11	hsa-miR-4753-5p	93.8015	NM_001308392
CDH11	hsa-miR-629-5p	92.6899	NM_001797
CDH11	hsa-miR-6739-5p	92.4472	NM_001308392
CDH11	hsa-miR-6868-3p	91.6389	NM_001797
CDH11	hsa-miR-6733-5p	90.6992	NM_001308392
CDH11	hsa-miR-3926	90.6716	NM_001308392
CDH11	hsa-miR-27a-3p	90.1029	NM_001308392
CDH11	hsa-miR-27b-3p	90.1029	NM_001308392
CDH11	hsa-miR-9985	90.1029	NM_001308392
CDH11	hsa-miR-3151-5p	90.0604	NM_001797
CDH11	hsa-miR-1279	90.0058	NM_001797
CDH11	hsa-miR-4277	89.9793	NM_001308392
CDH11	hsa-miR-3153	89.8643	NM_001308392
CDH11	hsa-miR-675-3p	89.637	NM_001797
CDH11	hsa-miR-10523-5p	89.4244	NM_001308392
CDH11	hsa-miR-3646	89.2487	NM_001308392
CDH11	hsa-miR-6844	87.9652	NM_001308392
CDH11	hsa-miR-205-3p	87.7424	NM_001308392
CDH11	hsa-miR-548c-3p	87.497	NM_001308392
CDH11	hsa-miR-1283	87.3721	NM_001308392
CDH11	hsa-miR-4666a-5p	86.778	NM_001308392
CDH11	hsa-miR-1255b-2-3p	86.4849	NM_001308392
CDH11	hsa-miR-219b-5p	86.1157	NM_001308392
CDH11	hsa-miR-576-5p	85.0803	NM_001797
CDH11	hsa-miR-1252-3p	85.0586	NM_001308392
CDH11	hsa-miR-548e-5p	84.9598	NM_001797
CDH11	hsa-miR-548u	84.447	NM_001308392
CDH11	hsa-miR-7161-5p	84.447	NM_001308392
CDH11	hsa-miR-381-3p	84.1336	NM_001797
CDH11	hsa-miR-300	84.1336	NM_001797

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Motifs and transcription factors (TFs) regulating CDH11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDH11	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CDH11	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CDH11	transfac_pro__M04617	ZBTB7A (directAnnotation).
CDH11	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CDH11	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CDH11	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CDH11	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CDH11	transfac_pro__M07387	ZBTB7A (directAnnotation).
CDH11	transfac_pro__M07436	WT1 (directAnnotation).
CDH11	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CDH11	transfac_pro__M00716	ZBTB14 (directAnnotation).
CDH11	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CDH11	hdpi__HIP2	UBE2K (directAnnotation).
CDH11	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDH11	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CDH11	transfac_pro__M04893	TAF1 (directAnnotation).
CDH11	transfac_pro__M03876	ZBTB33 (directAnnotation).
CDH11	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDH11	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CDH11	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CDH11	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDH11	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CDH11	"Celecoxib"	DB00482	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."