Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDC42BPA

Summary for CDC42BPA

Gene information	Gene symbol	CDC42BPA
	Ensembl ID	ENSG00000143776
	Entrez ID	8476
	Gene name	CDC42 binding protein kinase alpha
	Synonyms	FLJ23347\|KIAA0451\|MRCK\|MRCKA\|PK428
	Gene type	protein_coding
	UniProtAcc	Q5VT25

Top

Dataset with differentially expressed gene: CDC42BPA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.332997	0.00e+00

Top

Expression of CDC42BPA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CDC42BPA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CDC42BPA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDC42BPA	hsa-miR-5002-5p	98.9673	NM_003607
CDC42BPA	hsa-miR-6756-5p	96.7931	NM_003607
CDC42BPA	hsa-miR-6766-5p	96.2416	NM_003607
CDC42BPA	hsa-miR-3163	95.2895	NM_003607
CDC42BPA	hsa-miR-6888-3p	94.9857	NM_003607
CDC42BPA	hsa-miR-3662	94.8387	NM_003607
CDC42BPA	hsa-miR-887-5p	94.7849	NM_003607
CDC42BPA	hsa-miR-196a-3p	94.5758	NM_003607
CDC42BPA	hsa-miR-1249-5p	94.1358	NM_003607
CDC42BPA	hsa-miR-8073	93.662	NM_003607
CDC42BPA	hsa-miR-221-5p	93.662	NM_003607
CDC42BPA	hsa-miR-758-3p	93.4474	NM_003607
CDC42BPA	hsa-miR-323a-3p	93.0136	NM_003607
CDC42BPA	hsa-miR-6825-5p	92.3777	NM_003607
CDC42BPA	hsa-miR-6797-5p	91.7495	NM_003607
CDC42BPA	hsa-miR-182-5p	89.2547	NM_003607
CDC42BPA	hsa-miR-1224-3p	88.9016	NM_003607
CDC42BPA	hsa-miR-548x-5p	88.5287	NM_003607
CDC42BPA	hsa-miR-548g-5p	88.5287	NM_003607
CDC42BPA	hsa-miR-548f-5p	88.5287	NM_003607
CDC42BPA	hsa-miR-548aj-5p	88.5287	NM_003607
CDC42BPA	hsa-miR-6785-5p	88.0694	NM_003607
CDC42BPA	hsa-miR-7110-3p	87.7373	NM_003607
CDC42BPA	hsa-miR-586	87.5808	NM_003607
CDC42BPA	hsa-miR-6842-3p	87.1977	NM_003607
CDC42BPA	hsa-miR-29c-3p	86.3872	NM_003607
CDC42BPA	hsa-miR-29b-3p	86.3872	NM_003607
CDC42BPA	hsa-miR-29a-3p	86.3872	NM_003607
CDC42BPA	hsa-miR-6882-5p	85.6618	NM_003607
CDC42BPA	hsa-miR-4728-5p	85.6294	NM_003607
CDC42BPA	hsa-miR-6088	85.2211	NM_003607
CDC42BPA	hsa-miR-939-5p	85.2114	NM_003607
CDC42BPA	hsa-miR-19a-3p	85.0967	NM_003607
CDC42BPA	hsa-miR-19b-3p	85.0967	NM_003607
CDC42BPA	hsa-miR-6883-5p	85.0939	NM_003607
CDC42BPA	hsa-miR-149-3p	85.0939	NM_003607
CDC42BPA	hsa-miR-4770	84.9686	NM_003607
CDC42BPA	hsa-miR-143-3p	84.9686	NM_003607
CDC42BPA	hsa-miR-548ap-3p	84.7098	NM_003607
CDC42BPA	hsa-miR-548aa	84.7098	NM_003607
CDC42BPA	hsa-miR-548t-3p	84.7098	NM_003607
CDC42BPA	hsa-miR-6731-5p	83.9535	NM_003607
CDC42BPA	hsa-miR-181b-3p	83.4105	NM_003607
CDC42BPA	hsa-miR-181b-2-3p	83.4105	NM_003607
CDC42BPA	hsa-miR-4420	83.4105	NM_003607
CDC42BPA	hsa-miR-6873-3p	82.734	NM_003607
CDC42BPA	hsa-miR-4310	82.5854	NM_003607
CDC42BPA	hsa-miR-3128	82.4064	NM_003607
CDC42BPA	hsa-miR-12136	81.4674	NM_003607
CDC42BPA	hsa-miR-8085	81.0132	NM_003607

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CDC42BPA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDC42BPA	metacluster_7.13	ZFX (directAnnotation).
CDC42BPA	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CDC42BPA	metacluster_151.2	ZNF23 (directAnnotation).
CDC42BPA	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CDC42BPA	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CDC42BPA	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CDC42BPA	transfac_pro__M06071	ZNF814 (directAnnotation).
CDC42BPA	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CDC42BPA	jaspar__MA0079.5	SP1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."