Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDC27

Summary for CDC27

Gene information	Gene symbol	CDC27
	Ensembl ID	ENSG00000004897
	Entrez ID	996
	Gene name	cell division cycle 27
	Synonyms	ANAPC3\|APC3\|D0S1430E\|D17S978E\|NUC2
	Gene type	protein_coding
	UniProtAcc	P30260

Top

Dataset with differentially expressed gene: CDC27

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.302332	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.276204	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.286779	8.97e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.531491	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.260867	8.85e-17

Top

Expression of CDC27 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CDC27

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CDC27	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating CDC27

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDC27	hsa-miR-548aj-5p	95.7707	NM_001293091
CDC27	hsa-miR-548g-5p	95.7707	NM_001293091
CDC27	hsa-miR-548x-5p	95.7707	NM_001293091
CDC27	hsa-miR-548f-5p	93.9651	NM_001293091
CDC27	hsa-miR-1208	93.677	NM_001293091
CDC27	hsa-miR-1276	93.0574	NM_001293091
CDC27	hsa-miR-514a-5p	91.3126	NM_001293091
CDC27	hsa-miR-4422	91.1151	NM_001293091
CDC27	hsa-miR-646	90.2678	NM_001293091
CDC27	hsa-miR-10399-3p	90.2602	NM_001293091
CDC27	hsa-miR-5011-5p	90.0848	NM_001293091
CDC27	hsa-miR-587	89.6693	NM_001293091
CDC27	hsa-miR-8084	88.8514	NM_001293091
CDC27	hsa-miR-501-5p	88.7083	NM_001293091
CDC27	hsa-miR-205-5p	88.6662	NM_001293091
CDC27	hsa-miR-3664-5p	87.8713	NM_001293091
CDC27	hsa-miR-1249-5p	87.0416	NM_001293091
CDC27	hsa-miR-6797-5p	87.0416	NM_001293091
CDC27	hsa-miR-195-5p	86.9878	NM_001293091
CDC27	hsa-miR-16-5p	86.9878	NM_001293091
CDC27	hsa-miR-493-3p	86.6251	NM_001293091
CDC27	hsa-miR-192-3p	86.6193	NM_001293091
CDC27	hsa-miR-520f-5p	86.4348	NM_001293091
CDC27	hsa-miR-548b-3p	85.7643	NM_001293091
CDC27	hsa-miR-4477a	84.7487	NM_001293091
CDC27	hsa-miR-7108-5p	84.7483	NM_001293091
CDC27	hsa-miR-4282	84.6213	NM_001293091
CDC27	hsa-miR-7-2-3p	84.0633	NM_001293091
CDC27	hsa-miR-7-1-3p	84.0633	NM_001293091
CDC27	hsa-miR-183-3p	83.4978	NM_001293091
CDC27	hsa-miR-4524b-5p	83.2929	NM_001293091
CDC27	hsa-miR-4524a-5p	83.2929	NM_001293091
CDC27	hsa-miR-6515-5p	82.9276	NM_001293091
CDC27	hsa-miR-15b-5p	81.6946	NM_001293091
CDC27	hsa-miR-15a-5p	81.6946	NM_001293091
CDC27	hsa-miR-664a-5p	80.8412	NM_001293091
CDC27	hsa-miR-2052	80.7009	NM_001293091
CDC27	hsa-miR-4794	80.5927	NM_001293091
CDC27	hsa-miR-4635	80.501	NM_001293091
CDC27	hsa-miR-323a-3p	80.3584	NM_001293091
CDC27	hsa-miR-6838-5p	80.2422	NM_001293091

Page: 1

Top

Motifs and transcription factors (TFs) regulating CDC27

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDC27	metacluster_7.13	ZFX (directAnnotation).
CDC27	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CDC27	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CDC27	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CDC27	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CDC27	metacluster_182.10	ZFX (directAnnotation).
CDC27	hdpi__ETV4	ETV4 (directAnnotation).
CDC27	transfac_pro__M06071	ZNF814 (directAnnotation).
CDC27	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CDC27	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CDC27	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDC27	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDC27	transfac_pro__M02090	E2F4 (directAnnotation).
CDC27	transfac_pro__M01714	KLF15 (directAnnotation).
CDC27	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CDC27	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CDC27	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CDC27	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CDC27	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CDC27	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CDC27	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CDC27	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CDC27	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CDC27	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CDC27	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
CDC27	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CDC27	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CDC27	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CDC27	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CDC27	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CDC27	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CDC27	cisbp__M00788	ZFY (inferredBy_Orthology).
CDC27	metacluster_175.1	ZNF283 (directAnnotation).
CDC27	hdpi__ZNF304	ZNF304 (directAnnotation).
CDC27	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CDC27	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CDC27	transfac_pro__M01199	TRIM28 (directAnnotation).
CDC27	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CDC27	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."