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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD93

Summary for CD93

Gene information	Gene symbol	CD93
	Ensembl ID	ENSG00000125810
	Entrez ID	22918
	Gene name	CD93 molecule
	Synonyms	C1qR(P)\|C1QR1\|C1qRP\|CDw93\|dJ737E23.1\|ECSM3\|MXRA4
	Gene type	protein_coding
	UniProtAcc	Q9NPY3

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Dataset with differentially expressed gene: CD93

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.37508	6.83e-20
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.347386	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.444985	5.96e-22

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Expression of CD93 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD93

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	B cells	GSE164551	NA	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	CD4+ T cells	GSE164551	NA	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	CD8+ T cells	GSE164551	NA	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	Mono/Macro	GSE164551	NA	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	NK cells	GSE164551	NA	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	CD8+ T cells	GSE164551	NA	sensitive
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	Mono/Macro	GSE164551	NA	sensitive
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	NK cells	GSE164551	NA	sensitive
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	CD4+ T cells	GSE197268_Tisa-cel	pre	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	CD8+ T cells	GSE197268_Tisa-cel	pre	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	Mono/Macro	GSE197268_Tisa-cel	pre	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	NK cells	GSE197268_Tisa-cel	pre	resistant
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	CD8+ T cells	GSE197268_Tisa-cel	pre	sensitive
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	Mono/Macro	GSE197268_Tisa-cel	pre	sensitive
CD93	Mono/Macro	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Mono/Macro	NK cells	GSE197268_Tisa-cel	pre	sensitive
CD93	Malignant cells	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Malignant cells	CD8+ T cells	GSE199333	post	resistant
CD93	Malignant cells	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Malignant cells	Malignant cells	GSE199333	post	resistant
CD93	Malignant cells	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Malignant cells	NK cells	GSE199333	post	resistant
CD93	Malignant cells	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Malignant cells	CD4+ T cells	GSE199333	post	sensitive
CD93	Malignant cells	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Malignant cells	CD8+ T cells	GSE199333	post	sensitive
CD93	Malignant cells	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Malignant cells	Malignant cells	GSE199333	post	sensitive
CD93	Malignant cells	CPI-SS0B1650B85	CD93_IFNGR1	CD93	IFNGR1	False	Malignant cells	NK cells	GSE199333	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD93

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD93	hsa-miR-6867-5p	99.8941	NM_012072
CD93	hsa-miR-539-5p	93.5893	NM_012072
CD93	hsa-miR-6847-5p	93.4536	NM_012072
CD93	hsa-miR-5587-5p	92.561	NM_012072
CD93	hsa-miR-6830-3p	89.4717	NM_012072
CD93	hsa-miR-4511	88.9856	NM_012072
CD93	hsa-miR-3121-5p	87.3676	NM_012072
CD93	hsa-miR-4524a-3p	86.9433	NM_012072
CD93	hsa-miR-5680	86.9255	NM_012072
CD93	hsa-miR-6881-3p	86.3471	NM_012072
CD93	hsa-miR-3688-3p	86.1618	NM_012072
CD93	hsa-miR-7152-5p	85.8747	NM_012072
CD93	hsa-miR-1179	84.8843	NM_012072
CD93	hsa-miR-3605-5p	83.0609	NM_012072
CD93	hsa-miR-8485	82.8768	NM_012072
CD93	hsa-miR-3664-3p	82.8253	NM_012072
CD93	hsa-miR-607	82.5328	NM_012072
CD93	hsa-miR-2117	81.4306	NM_012072
CD93	hsa-miR-4761-5p	80.846	NM_012072

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Motifs and transcription factors (TFs) regulating CD93

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD93	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
CD93	jaspar__MA1509.1	IRF6 (directAnnotation).
CD93	metacluster_9.47	PAX7 (inferredBy_Orthology).
CD93	transfac_pro__M06092	ZNF28 (directAnnotation).
CD93	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
CD93	metacluster_79.2	ZNF436 (inferredBy_Orthology).
CD93	tfdimers__MD00591	SRY; TFAP2C (directAnnotation).
CD93	metacluster_144.13	HIC1; HIC1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."