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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD81

Summary for CD81

Gene information	Gene symbol	CD81
	Ensembl ID	ENSG00000110651
	Entrez ID	975
	Gene name	CD81 molecule
	Synonyms	TAPA-1\|TAPA1\|TSPAN28
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CD81

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.905051	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.39951	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.257555	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.327427	2.06e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.359312	6.31e-22
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.25575	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	CD4+ T cells	0.298233	1.26e-21
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	CD8+ T cells	0.460999	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	0.599655	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.379304	5.40e-06
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.721942	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.291287	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.427666	2.90e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.407975	5.31e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.288043	9.95e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.73883	1.60e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.384406	1.91e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.423358	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.693133	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.557807	1.35e-34
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.40867	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.626822	0.00e+00

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Expression of CD81 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD81

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD81

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD81	hsa-miR-6126	94.1327	NM_004356
CD81	hsa-miR-605-3p	93.799	NM_004356
CD81	hsa-miR-6771-3p	91.0931	NM_004356
CD81	hsa-miR-6768-5p	90.3886	NM_001297649
CD81	hsa-miR-8070	89.8909	NM_004356
CD81	hsa-miR-6868-3p	87.9712	NM_004356
CD81	hsa-miR-5000-5p	87.2607	NM_001297649
CD81	hsa-miR-1248	87.1631	NM_001297649
CD81	hsa-miR-582-5p	86.372	NM_004356
CD81	hsa-miR-4493	85.9649	NM_004356
CD81	hsa-miR-7976	83.3952	NM_004356
CD81	hsa-miR-4789-5p	82.2788	NM_001297649
CD81	hsa-miR-589-3p	80.1154	NM_004356

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Motifs and transcription factors (TFs) regulating CD81

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD81	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CD81	jaspar__MA1933.1	SREBF2 (directAnnotation).
CD81	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CD81	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CD81	transfac_pro__M01122	ZNF219 (directAnnotation).
CD81	transfac_public__M00415	ZEB1 (directAnnotation).
CD81	transfac_pro__M01175	ZBTB7B (directAnnotation).
CD81	transfac_pro__M04595	SALL2 (directAnnotation).
CD81	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CD81	transfac_pro__M12686	ZBTB10 (directAnnotation).
CD81	transfac_pro__M01104	OVOL2 (directAnnotation).
CD81	transfac_pro__M00986	CHURC1 (directAnnotation).
CD81	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
CD81	transfac_pro__M05432	ZSCAN18 (directAnnotation).
CD81	tfdimers__MD00041	CRX; HMBOX1 (directAnnotation).
CD81	tfdimers__MD00210	CDX2; HMBOX1 (directAnnotation).
CD81	tfdimers__MD00157	MYB; TLX2 (directAnnotation).
CD81	tfdimers__MD00546	HOXC8; NFE2L1 (directAnnotation).
CD81	metacluster_119.1	ZNF677 (directAnnotation).
CD81	tfdimers__MD00549	CRX (directAnnotation).
CD81	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
CD81	tfdimers__MD00416	HNF1A; HNF1B (directAnnotation).
CD81	kznf__ZSCAN29_TF_Evolution_PBM	ZSCAN29 (directAnnotation).
CD81	transfac_pro__M12358	MLX (inferredBy_Orthology).
CD81	transfac_pro__M06816	ZNF263 (inferredBy_Orthology).
CD81	kznf__ZNF705G_Imbeault2017_OM_MEME	ZNF705G (directAnnotation).
CD81	metacluster_97.2	GTF3A (inferredBy_Orthology).
CD81	transfac_pro__M06547	ZNF675 (directAnnotation).
CD81	metacluster_74.16	HNF1A (directAnnotation).
CD81	transfac_pro__M05619	ZSCAN5C (directAnnotation).
CD81	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
CD81	tfdimers__MD00048	CDX2; IKZF1 (directAnnotation).
CD81	metacluster_29.1	STAT4; STAT5A; STAT5A; STAT5B (directAnnotation). STAT5B; STAT5B (inferredBy_Orthology).
CD81	metacluster_78.15	PAX7 (directAnnotation).
CD81	metacluster_150.1	PAX4 (directAnnotation).
CD81	transfac_pro__M02080	ISL2 (directAnnotation).
CD81	transfac_pro__M06654	ZNF559 (directAnnotation).
CD81	jaspar__MA1489.1	FOXN3 (directAnnotation).
CD81	taipale_tf_pairs__CUX1_PITX1_GGATTANNNNATCRATN_CAP_repr	CUX1; PITX1 (directAnnotation).
CD81	transfac_pro__M06267	ZNF805 (directAnnotation).
CD81	taipale_tf_pairs__CUX1_SRF_NCCATAYWNGGWNNNNATCRATN_CAP_repr	CUX1; SRF (directAnnotation).
CD81	swissregulon__hs__SPI1	SPI1 (directAnnotation).
CD81	taipale_tf_pairs__MEIS1_DRGX_TGACASTAATKR_CAP_repr	DRGX; MEIS1 (directAnnotation).
CD81	transfac_pro__M04785	RAD21 (directAnnotation).
CD81	tfdimers__MD00094	NR1H4; NR1I2; NR1I3; PBX1; RXRA (directAnnotation).
CD81	transfac_pro__M00671	TCF7L2 (directAnnotation).
CD81	transfac_pro__M02085	BCL6 (directAnnotation).
CD81	metacluster_33.3	ZNF134; ZNF174 (directAnnotation).
CD81	taipale_tf_pairs__MYBL1_TBX21_AGGTGTGNCSGTTR_CAP_repr	MYBL1; TBX21 (directAnnotation).
CD81	transfac_pro__M01207	ETS2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."