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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD58

Summary for CD58

Gene information	Gene symbol	CD58
	Ensembl ID	ENSG00000116815
	Entrez ID	965
	Gene name	CD58 molecule
	Synonyms	LFA3
	Gene type	protein_coding
	UniProtAcc	P19256

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Dataset with differentially expressed gene: CD58

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.5551	3.47e-20
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.497048	3.49e-30
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.638717	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.272032	4.59e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.369606	1.43e-42

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Expression of CD58 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD58

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CD58	Malignant cells	CPI-SS029C16DCA	CD58_CD2	CD58	CD2	False	Malignant cells	NK cells	GSE153697	NA	resistant
CD58	Malignant cells	CPI-SS029C16DCA	CD58_CD2	CD58	CD2	False	Malignant cells	NK cells	GSE153697	NA	sensitive
CD58	Malignant cells	CPI-SS029C16DCA	CD58_CD2	CD58	CD2	False	Malignant cells	CD4+ T cells	GSE189460	pre	resistant
CD58	Malignant cells	CPI-SS029C16DCA	CD58_CD2	CD58	CD2	False	Malignant cells	CD8+ T cells	GSE189460	pre	resistant
CD58	Malignant cells	CPI-SS029C16DCA	CD58_CD2	CD58	CD2	False	Malignant cells	NK cells	GSE189460	pre	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD58

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD58	hsa-miR-6505-3p	89.2183	NM_001144822
CD58	hsa-miR-888-5p	88.8757	NM_001779
CD58	hsa-miR-3119	88.2544	NM_001779
CD58	hsa-miR-4659b-3p	88.045	NM_001779
CD58	hsa-miR-4659a-3p	88.045	NM_001779
CD58	hsa-miR-888-3p	87.7411	NM_001779
CD58	hsa-miR-1289	83.9294	NM_001144822
CD58	hsa-miR-3177-5p	83.4168	NM_001779
CD58	hsa-miR-32-3p	83.0144	NM_001779
CD58	hsa-miR-545-5p	81.5153	NM_001779
CD58	hsa-miR-93-3p	80.6793	NM_001144822

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Motifs and transcription factors (TFs) regulating CD58

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD58	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CD58	cisbp__M00341	PAX6 (directAnnotation).
CD58	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CD58	jaspar__MA0748.2	YY2 (directAnnotation).
CD58	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."