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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CD3G

Summary for CD3G

Gene information	Gene symbol	CD3G
	Ensembl ID	ENSG00000160654
	Entrez ID	917
	Gene name	CD3 gamma subunit of T-cell receptor complex
	Synonyms	CD3-GAMMA\|CD3GAMMA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CD3G

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.308982	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.300799	2.05e-43
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.261754	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.286522	5.26e-28
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.254007	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.360122	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.40432	1.03e-07
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.457054	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.288623	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	0.305708	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.787284	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	0.333941	1.54e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	1.41661	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	1.26643	1.65e-29
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.35356	4.83e-10
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.617198	9.39e-11
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.442889	3.27e-12
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	NK cells	-0.342744	3.42e-15
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	NK cells	-0.677778	0.00e+00

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Expression of CD3G in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD3G

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD3G

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD3G	hsa-miR-4314	91.7418	NM_000073
CD3G	hsa-miR-181b-2-3p	87.8271	NM_000073
CD3G	hsa-miR-4420	87.8271	NM_000073
CD3G	hsa-miR-181b-3p	87.8271	NM_000073
CD3G	hsa-miR-371b-5p	84.3259	NM_000073
CD3G	hsa-miR-373-5p	84.3259	NM_000073
CD3G	hsa-miR-616-5p	84.3259	NM_000073
CD3G	hsa-miR-593-3p	83.1282	NM_000073
CD3G	hsa-miR-3613-3p	82.6872	NM_000073
CD3G	hsa-miR-6817-3p	81.7395	NM_000073
CD3G	hsa-miR-6818-3p	80.5323	NM_000073

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Motifs and transcription factors (TFs) regulating CD3G

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD3G	taipale_cyt_meth__LBX2_CTCGTTAN_eDBD	LBX2 (directAnnotation).
CD3G	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CD3G	jaspar__MA0095.3	YY1 (inferredBy_Orthology).
CD3G	tfdimers__MD00210	CDX2; HMBOX1 (directAnnotation).
CD3G	tfdimers__MD00066	ELF1 (directAnnotation).
CD3G	transfac_pro__M06826	ZNF516 (inferredBy_Orthology).
CD3G	metacluster_183.3	EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
CD3G	metacluster_35.3	EHF; EHF; EHF; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF2; ELF2; ELF2; ELF2; ELF2; ELF3; ELF3; ELF3; ELF3; ELF4; ELF4; ELF4; ELF4; ELF5; ELF5; ELF5; ELF5; ELK3; ERG; ETV2; ETV2; ETV5; FLI1; FLI1; ZNF639 (directAnnotation). EHF; ELF4; ETS1; FLI1; SPDEF (inferredBy_Orthology).
CD3G	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
CD3G	jaspar__MA1483.2	ELF2 (directAnnotation).
CD3G	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
CD3G	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CD3G	transfac_pro__M06833	PEG3 (directAnnotation).
CD3G	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CD3G	jaspar__MA1963.1	SATB1 (directAnnotation).
CD3G	transfac_pro__M06102	ZNF16 (directAnnotation).
CD3G	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
CD3G	tfdimers__MD00377	PBX1 (directAnnotation).
CD3G	metacluster_139.9	TFE3 (inferredBy_Orthology).
CD3G	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CD3G	hdpi__FLI1	FLI1 (directAnnotation).
CD3G	jaspar__MA1958.1	HOXD12 (directAnnotation).
CD3G	taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTCGTAAAN_CAP	ETV4; HOXD12 (directAnnotation).
CD3G	metacluster_141.4	GLIS2 (directAnnotation).
CD3G	tfdimers__MD00527	IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation).
CD3G	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
CD3G	transfac_pro__M04944	GABPA (directAnnotation).
CD3G	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CD3G	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
CD3G	tfdimers__MD00194	NFATC3; ZEB1 (directAnnotation).
CD3G	transfac_pro__M05447	INSM2 (inferredBy_Orthology).
CD3G	metacluster_106.2	ZBTB32 (directAnnotation).
CD3G	metacluster_164.2	HMBOX1 (directAnnotation).
CD3G	metacluster_6.1	HMBOX1 (directAnnotation).
CD3G	transfac_pro__M04890	BATF (directAnnotation).
CD3G	metacluster_86.5	ZNF324; ZNF418 (directAnnotation).
CD3G	tfdimers__MD00425	ELF5; SMAD4 (directAnnotation).
CD3G	transfac_pro__M06301	ZNF404 (directAnnotation).
CD3G	tfdimers__MD00485	MYCN (directAnnotation).
CD3G	transfac_pro__M06185	ZNF92 (directAnnotation).
CD3G	transfac_pro__M01861	ATF1 (directAnnotation).
CD3G	tfdimers__MD00453	ATF3; CRX (directAnnotation).
CD3G	transfac_pro__M01660	GABPA (directAnnotation).
CD3G	jaspar__MA0136.3	ELF5 (inferredBy_Orthology).
CD3G	transfac_pro__M12556	ETV4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CD3G	"Muromonab"	DB00075	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."