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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD36

Summary for CD36

Gene information	Gene symbol	CD36
	Ensembl ID	ENSG00000135218
	Entrez ID	948
	Gene name	CD36 molecule
	Synonyms	FAT\|GP3B\|GP4\|GPIV\|SCARB3
	Gene type	protein_coding
	UniProtAcc	P16671

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Dataset with differentially expressed gene: CD36

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.37303	6.20e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.364717	1.86e-03
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.26836	3.31e-26
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.510077	5.10e-34
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.556065	1.89e-27
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.531317	3.14e-04
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	Mono/Macro	-0.33416	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.359006	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.337876	4.47e-14
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.613561	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.60391	0.00e+00

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Expression of CD36 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD36

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CD36	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CD36

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD36	hsa-miR-8485	97.5532	NM_001001548
CD36	hsa-miR-4719	96.5072	NM_001001548
CD36	hsa-miR-6830-3p	96.4023	NM_001001548
CD36	hsa-miR-548e-5p	95.6232	NM_001001548
CD36	hsa-miR-6854-5p	95.301	NM_001001548
CD36	hsa-miR-589-3p	94.1102	NM_001001548
CD36	hsa-miR-1277-5p	93.5605	NM_001127443
CD36	hsa-miR-4520-5p	93.5364	NM_001127443
CD36	hsa-miR-629-3p	93.2707	NM_001127443
CD36	hsa-miR-4650-3p	92.1288	NM_001001548
CD36	hsa-miR-3609	90.1252	NM_001127443
CD36	hsa-miR-5011-5p	89.8528	NM_001127443
CD36	hsa-miR-3942-3p	89.663	NM_001001548
CD36	hsa-miR-155-5p	88.6498	NM_001001548
CD36	hsa-miR-340-5p	88.3739	NM_001001548
CD36	hsa-miR-3924	86.9085	NM_001001548
CD36	hsa-miR-3180-5p	86.0371	NM_001001548
CD36	hsa-miR-548ah-5p	85.9424	NM_001127443
CD36	hsa-miR-511-5p	85.7368	NM_001001548
CD36	hsa-miR-3934-3p	85.3973	NM_001001548
CD36	hsa-miR-5579-3p	84.9291	NM_001001548
CD36	hsa-miR-4713-5p	84.1981	NM_001127443
CD36	hsa-miR-5190	84.0379	NM_001001548
CD36	hsa-miR-3148	81.8726	NM_001001548
CD36	hsa-miR-5589-3p	81.0633	NM_001001548
CD36	hsa-miR-425-5p	80.2477	NM_001001548
CD36	hsa-miR-485-3p	80.0265	NM_001001548
CD36	hsa-miR-539-3p	80.0265	NM_001001548

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Motifs and transcription factors (TFs) regulating CD36

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD36	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CD36	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CD36	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CD36	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
CD36	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
CD36	metacluster_22.37	BACH1 (directAnnotation).
CD36	metacluster_22.34	BACH2 (directAnnotation).
CD36	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CD36	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
CD36	metacluster_22.33	MAFK (inferredBy_Orthology).
CD36	jaspar__MA1125.1	ZNF384 (directAnnotation).
CD36	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
CD36	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
CD36	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
CD36	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
CD36	transfac_pro__M06401	ZNF551 (directAnnotation).
CD36	transfac_pro__M05916	ZNF407 (directAnnotation).
CD36	transfac_pro__M06569	ZNF775 (directAnnotation).
CD36	transfac_pro__M06157	ZNF445 (directAnnotation).
CD36	transfac_pro__M06733	RBAK (directAnnotation).
CD36	transfac_pro__M01969	FOXO1 (directAnnotation).
CD36	transfac_pro__M06969	EBF4 (inferredBy_Orthology).
CD36	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).
CD36	transfac_pro__M02830	ZSCAN26 (inferredBy_Orthology).
CD36	taipale_tf_pairs__HOXB2_RFX5_TAATKRNNNNGCAAC_CAP_repr	HOXB2; RFX5 (directAnnotation).
CD36	transfac_pro__M05451	ZNF541 (directAnnotation).
CD36	transfac_pro__M06016	ZNF729 (directAnnotation).
CD36	transfac_pro__M01239	RELA (directAnnotation).
CD36	transfac_pro__M05984	ZNF586 (directAnnotation).
CD36	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
CD36	metacluster_26.9	ZNF354B (directAnnotation).
CD36	metacluster_22.2	MAFK (directAnnotation).
CD36	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
CD36	transfac_pro__M04722	SPI1 (directAnnotation).
CD36	jaspar__MA1509.1	IRF6 (directAnnotation).
CD36	transfac_pro__M05743	ZNF57 (directAnnotation).
CD36	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
CD36	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
CD36	taipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAP	FLI1; MAX (directAnnotation).
CD36	taipale_tf_pairs__RFX3_ETV7_NNNMGGAANNNNNTCCNNNRCAACN_CAP_repr	ETV7; RFX3 (directAnnotation).
CD36	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CD36	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
CD36	transfac_pro__M06467	ZNF695 (directAnnotation).
CD36	tfdimers__MD00036	FOS; FOSB; FOSL1; FOSL2; ILF2; JUN; JUNB; JUND; NFATC2 (directAnnotation).
CD36	metacluster_79.36	BRCA1 (directAnnotation).
CD36	transfac_pro__M04706	RELA (directAnnotation).
CD36	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
CD36	transfac_pro__M06078	ZNF878 (directAnnotation).
CD36	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
CD36	tfdimers__MD00313	ING4; NFATC4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."