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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD2AP

Summary for CD2AP

Gene information	Gene symbol	CD2AP
	Ensembl ID	ENSG00000198087
	Entrez ID	23607
	Gene name	CD2 associated protein
	Synonyms	CMS
	Gene type	protein_coding
	UniProtAcc	Q9Y5K6

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Dataset with differentially expressed gene: CD2AP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.21857	9.71e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.258453	1.81e-20
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.331809	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.560617	2.65e-21

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Expression of CD2AP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD2AP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD2AP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD2AP	hsa-miR-5011-5p	99.8489	NM_012120
CD2AP	hsa-miR-8485	99.6503	NM_012120
CD2AP	hsa-miR-4753-3p	99.6416	NM_012120
CD2AP	hsa-miR-182-5p	99.448	NM_012120
CD2AP	hsa-miR-1277-5p	99.0175	NM_012120
CD2AP	hsa-miR-5582-5p	98.8558	NM_012120
CD2AP	hsa-miR-190a-3p	98.7471	NM_012120
CD2AP	hsa-miR-4775	97.4881	NM_012120
CD2AP	hsa-miR-130a-5p	97.3993	NM_012120
CD2AP	hsa-miR-548n	96.5165	NM_012120
CD2AP	hsa-miR-199b-3p	95.8109	NM_012120
CD2AP	hsa-miR-3129-5p	95.8109	NM_012120
CD2AP	hsa-miR-199a-3p	95.8109	NM_012120
CD2AP	hsa-miR-33a-3p	95.5095	NM_012120
CD2AP	hsa-miR-130b-5p	95.4542	NM_012120
CD2AP	hsa-miR-6892-3p	95.2073	NM_012120
CD2AP	hsa-miR-222-5p	94.9468	NM_012120
CD2AP	hsa-miR-4482-3p	94.7885	NM_012120
CD2AP	hsa-miR-206	94.7331	NM_012120
CD2AP	hsa-miR-1-3p	94.7331	NM_012120
CD2AP	hsa-miR-3679-5p	94.4666	NM_012120
CD2AP	hsa-miR-1185-5p	94.4666	NM_012120
CD2AP	hsa-miR-30a-5p	94.2917	NM_012120
CD2AP	hsa-miR-30d-5p	94.2917	NM_012120
CD2AP	hsa-miR-30c-5p	94.2917	NM_012120
CD2AP	hsa-miR-30b-5p	94.2917	NM_012120
CD2AP	hsa-miR-30e-5p	94.2917	NM_012120
CD2AP	hsa-miR-613	94.1757	NM_012120
CD2AP	hsa-miR-5692a	93.7429	NM_012120
CD2AP	hsa-miR-4282	93.6531	NM_012120
CD2AP	hsa-miR-548c-3p	93.338	NM_012120
CD2AP	hsa-miR-95-5p	93.2199	NM_012120
CD2AP	hsa-miR-195-5p	92.7195	NM_012120
CD2AP	hsa-miR-15a-5p	92.7195	NM_012120
CD2AP	hsa-miR-15b-5p	92.7195	NM_012120
CD2AP	hsa-miR-16-5p	92.7195	NM_012120
CD2AP	hsa-miR-5002-5p	92.1428	NM_012120
CD2AP	hsa-miR-450b-5p	91.7487	NM_012120
CD2AP	hsa-miR-586	91.6172	NM_012120
CD2AP	hsa-miR-6074	91.2309	NM_012120
CD2AP	hsa-miR-6838-5p	90.8865	NM_012120
CD2AP	hsa-miR-497-5p	90.8865	NM_012120
CD2AP	hsa-miR-424-5p	90.8865	NM_012120
CD2AP	hsa-miR-129-5p	90.605	NM_012120
CD2AP	hsa-miR-9983-3p	90.5922	NM_012120
CD2AP	hsa-miR-4679	89.8739	NM_012120
CD2AP	hsa-miR-188-5p	89.436	NM_012120
CD2AP	hsa-miR-6866-3p	89.436	NM_012120
CD2AP	hsa-miR-137-3p	88.912	NM_012120
CD2AP	hsa-miR-936	88.6165	NM_012120

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Motifs and transcription factors (TFs) regulating CD2AP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD2AP	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CD2AP	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CD2AP	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CD2AP	transfac_pro__M04617	ZBTB7A (directAnnotation).
CD2AP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CD2AP	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CD2AP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CD2AP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CD2AP	transfac_pro__M07387	ZBTB7A (directAnnotation).
CD2AP	transfac_pro__M07436	WT1 (directAnnotation).
CD2AP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CD2AP	transfac_pro__M00716	ZBTB14 (directAnnotation).
CD2AP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CD2AP	hdpi__HIP2	UBE2K (directAnnotation).
CD2AP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CD2AP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CD2AP	transfac_pro__M04893	TAF1 (directAnnotation).
CD2AP	transfac_pro__M03876	ZBTB33 (directAnnotation).
CD2AP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CD2AP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CD2AP	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CD2AP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CD2AP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CD2AP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CD2AP	metacluster_7.13	ZFX (directAnnotation).
CD2AP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CD2AP	cisbp__M00968	MTF2 (directAnnotation).
CD2AP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CD2AP	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CD2AP	cisbp__M00341	PAX6 (directAnnotation).
CD2AP	metacluster_198.3	ZFP64 (directAnnotation).
CD2AP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CD2AP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CD2AP	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CD2AP	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CD2AP	cisbp__M00788	ZFY (inferredBy_Orthology).
CD2AP	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CD2AP	metacluster_175.1	ZNF283 (directAnnotation).
CD2AP	hdpi__ZNF304	ZNF304 (directAnnotation).
CD2AP	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CD2AP	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CD2AP	transfac_pro__M01199	TRIM28 (directAnnotation).
CD2AP	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CD2AP	metacluster_151.2	ZNF23 (directAnnotation).
CD2AP	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CD2AP	transfac_pro__M03806	ZBTB7C (directAnnotation).
CD2AP	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CD2AP	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CD2AP	kznf__ZNF778_Imbeault2017_RP_RCADE	ZNF778 (directAnnotation).
CD2AP	jaspar__MA1951.1	FOS (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."